Effects of weight loss in obese subjects with normal fasting plasma glucose or impaired glucose tolerance on insulin release and insulin resistance according to a minimal model analysis
We investigated effects of weight loss from diet and exercise regimen in obese subjects with normal fasting plasma glucose or impaired glucose tolerance (IGT) on insulin release capacity and insulin sensitivity. Eight subjects were recruited among visceral obesity patients (4 men, 4 women; age range...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 2004-09, Vol.53 (9), p.1095-1100 |
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| creator | Yoshida, Yuriko Hashimoto, Naotake Tokuyama, Yoshiharu Kitagawa, Hiroshi Takahashi, Kazuo Yagui, Kazuo Kanatsuka, Azuma Bujo, Hideaki Higurashi, Mayumi Miyazawa, Saori Yoshida, Shouji Saito, Yasushi |
| description | We investigated effects of weight loss from diet and exercise regimen in obese subjects with normal fasting plasma glucose or impaired glucose tolerance (IGT) on insulin release capacity and insulin sensitivity. Eight subjects were recruited among visceral obesity patients (4 men, 4 women; age range, 24 to 57 years; body mass index [BMI], 32.8 to 60.3 kg/m
2). All were admitted to Chiba University Hospital for 2 weeks, were treated with a tapering 5,023 to 2,930 kJ diet, and were given exercise equivalent to 628 kJ/d. For assessments, we used a combination of C-peptide secretion rate determination and minimal model analysis as previously reported. BMI and visceral fat area (V) significantly decreased (BMI on initiation
v after intervention, 43.0 ± 3.2
v 40.3 ± 3.1 kg/m
2,
P < .05; V, 224 ± 22
v 188 ± 22 cm
2;
P < .05). Fasting immunoreactive insulin (F-IRI) and leptin concentrations decreased significantly. Capacity for insulin release in response to glucose increased in all subjects (first-phase insulin secretion [CS1], 4.66 ± 4.05
v 6.81 ± 4.57 ng/mL/5 min,
P < .05), but the insulin sensitivity index (S
i) did not change significantly. These data suggest that weight reduction early in development of type 2 diabetes can oppose progression of diabetes by improving capacity for insulin release. |
| doi_str_mv | 10.1016/j.metabol.2004.04.002 |
| format | Article |
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2). All were admitted to Chiba University Hospital for 2 weeks, were treated with a tapering 5,023 to 2,930 kJ diet, and were given exercise equivalent to 628 kJ/d. For assessments, we used a combination of C-peptide secretion rate determination and minimal model analysis as previously reported. BMI and visceral fat area (V) significantly decreased (BMI on initiation
v after intervention, 43.0 ± 3.2
v 40.3 ± 3.1 kg/m
2,
P < .05; V, 224 ± 22
v 188 ± 22 cm
2;
P < .05). Fasting immunoreactive insulin (F-IRI) and leptin concentrations decreased significantly. Capacity for insulin release in response to glucose increased in all subjects (first-phase insulin secretion [CS1], 4.66 ± 4.05
v 6.81 ± 4.57 ng/mL/5 min,
P < .05), but the insulin sensitivity index (S
i) did not change significantly. These data suggest that weight reduction early in development of type 2 diabetes can oppose progression of diabetes by improving capacity for insulin release.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/j.metabol.2004.04.002</identifier><identifier>PMID: 15334366</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adipose Tissue - physiology ; Adult ; Biological and medical sciences ; Blood Glucose - metabolism ; Body Mass Index ; C-Peptide - metabolism ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Exercise Therapy ; Female ; Glucose Intolerance - metabolism ; Humans ; Insulin - blood ; Insulin - metabolism ; Insulin Resistance - physiology ; Lipids - blood ; Male ; Medical sciences ; Middle Aged ; Models, Biological ; Obesity - diet therapy ; Obesity - physiopathology ; Obesity - therapy ; Weight Loss - physiology</subject><ispartof>Metabolism, clinical and experimental, 2004-09, Vol.53 (9), p.1095-1100</ispartof><rights>2004 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-544d306a8d4264383e9e5c081882b1f91a271b6a3a36716980f8eca99e30f0f3</citedby><cites>FETCH-LOGICAL-c391t-544d306a8d4264383e9e5c081882b1f91a271b6a3a36716980f8eca99e30f0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0026049504001982$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16115930$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15334366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshida, Yuriko</creatorcontrib><creatorcontrib>Hashimoto, Naotake</creatorcontrib><creatorcontrib>Tokuyama, Yoshiharu</creatorcontrib><creatorcontrib>Kitagawa, Hiroshi</creatorcontrib><creatorcontrib>Takahashi, Kazuo</creatorcontrib><creatorcontrib>Yagui, Kazuo</creatorcontrib><creatorcontrib>Kanatsuka, Azuma</creatorcontrib><creatorcontrib>Bujo, Hideaki</creatorcontrib><creatorcontrib>Higurashi, Mayumi</creatorcontrib><creatorcontrib>Miyazawa, Saori</creatorcontrib><creatorcontrib>Yoshida, Shouji</creatorcontrib><creatorcontrib>Saito, Yasushi</creatorcontrib><title>Effects of weight loss in obese subjects with normal fasting plasma glucose or impaired glucose tolerance on insulin release and insulin resistance according to a minimal model analysis</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>We investigated effects of weight loss from diet and exercise regimen in obese subjects with normal fasting plasma glucose or impaired glucose tolerance (IGT) on insulin release capacity and insulin sensitivity. Eight subjects were recruited among visceral obesity patients (4 men, 4 women; age range, 24 to 57 years; body mass index [BMI], 32.8 to 60.3 kg/m
2). All were admitted to Chiba University Hospital for 2 weeks, were treated with a tapering 5,023 to 2,930 kJ diet, and were given exercise equivalent to 628 kJ/d. For assessments, we used a combination of C-peptide secretion rate determination and minimal model analysis as previously reported. BMI and visceral fat area (V) significantly decreased (BMI on initiation
v after intervention, 43.0 ± 3.2
v 40.3 ± 3.1 kg/m
2,
P < .05; V, 224 ± 22
v 188 ± 22 cm
2;
P < .05). Fasting immunoreactive insulin (F-IRI) and leptin concentrations decreased significantly. Capacity for insulin release in response to glucose increased in all subjects (first-phase insulin secretion [CS1], 4.66 ± 4.05
v 6.81 ± 4.57 ng/mL/5 min,
P < .05), but the insulin sensitivity index (S
i) did not change significantly. These data suggest that weight reduction early in development of type 2 diabetes can oppose progression of diabetes by improving capacity for insulin release.</description><subject>Adipose Tissue - physiology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body Mass Index</subject><subject>C-Peptide - metabolism</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Exercise Therapy</subject><subject>Female</subject><subject>Glucose Intolerance - metabolism</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin - metabolism</subject><subject>Insulin Resistance - physiology</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>Obesity - diet therapy</subject><subject>Obesity - physiopathology</subject><subject>Obesity - therapy</subject><subject>Weight Loss - physiology</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6E5Rc9NZj0unOJCeRZf2ABS97D9XpymyGdGdM0i770_x3pncG15tQUFD11AfvS8hbzraccfnxsJ2wwBDDtmWs267B2mdkw3vRNkoy9pxsakU2rNP9BXmV84Exttsp-ZJcVEh0QsoN-X3tHNqSaXT0Hv3-rtAQc6Z-pnHAjDQvw-ERuPfljs4xTRCog1z8vKfHAHkCug-LjZWNifrpCD7h-LdWYsAEs63duW7NS6irEwaE2oR5_KeWfS6PJFgb07geKJECnfzs16tTHDHUGQgPFX1NXjgIGd-c8yW5_XJ9e_Wtufnx9fvV55vGCs1L03fdKJgENXat7IQSqLG3THGl2oE7zaHd8UGCACF3XGrFnEILWqNgjjlxST6c1h5T_LlgLmby2WIIMGNcspFSca2lqmB_Am2qAiZ05pjq2-nBcGZWy8zBnC0zq2VmDdbWuXfnA8sw4fg0dfaoAu_PAGQLwa1q-vzESc57LVjlPp04rGr88phMth6rnmM1xBYzRv-fV_4AwuG7ZQ</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Yoshida, Yuriko</creator><creator>Hashimoto, Naotake</creator><creator>Tokuyama, Yoshiharu</creator><creator>Kitagawa, Hiroshi</creator><creator>Takahashi, Kazuo</creator><creator>Yagui, Kazuo</creator><creator>Kanatsuka, Azuma</creator><creator>Bujo, Hideaki</creator><creator>Higurashi, Mayumi</creator><creator>Miyazawa, Saori</creator><creator>Yoshida, Shouji</creator><creator>Saito, Yasushi</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Effects of weight loss in obese subjects with normal fasting plasma glucose or impaired glucose tolerance on insulin release and insulin resistance according to a minimal model analysis</title><author>Yoshida, Yuriko ; Hashimoto, Naotake ; Tokuyama, Yoshiharu ; Kitagawa, Hiroshi ; Takahashi, Kazuo ; Yagui, Kazuo ; Kanatsuka, Azuma ; Bujo, Hideaki ; Higurashi, Mayumi ; Miyazawa, Saori ; Yoshida, Shouji ; Saito, Yasushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-544d306a8d4264383e9e5c081882b1f91a271b6a3a36716980f8eca99e30f0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adipose Tissue - physiology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Body Mass Index</topic><topic>C-Peptide - metabolism</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Exercise Therapy</topic><topic>Female</topic><topic>Glucose Intolerance - metabolism</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin - metabolism</topic><topic>Insulin Resistance - physiology</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>Obesity - diet therapy</topic><topic>Obesity - physiopathology</topic><topic>Obesity - therapy</topic><topic>Weight Loss - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshida, Yuriko</creatorcontrib><creatorcontrib>Hashimoto, Naotake</creatorcontrib><creatorcontrib>Tokuyama, Yoshiharu</creatorcontrib><creatorcontrib>Kitagawa, Hiroshi</creatorcontrib><creatorcontrib>Takahashi, Kazuo</creatorcontrib><creatorcontrib>Yagui, Kazuo</creatorcontrib><creatorcontrib>Kanatsuka, Azuma</creatorcontrib><creatorcontrib>Bujo, Hideaki</creatorcontrib><creatorcontrib>Higurashi, Mayumi</creatorcontrib><creatorcontrib>Miyazawa, Saori</creatorcontrib><creatorcontrib>Yoshida, Shouji</creatorcontrib><creatorcontrib>Saito, Yasushi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshida, Yuriko</au><au>Hashimoto, Naotake</au><au>Tokuyama, Yoshiharu</au><au>Kitagawa, Hiroshi</au><au>Takahashi, Kazuo</au><au>Yagui, Kazuo</au><au>Kanatsuka, Azuma</au><au>Bujo, Hideaki</au><au>Higurashi, Mayumi</au><au>Miyazawa, Saori</au><au>Yoshida, Shouji</au><au>Saito, Yasushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of weight loss in obese subjects with normal fasting plasma glucose or impaired glucose tolerance on insulin release and insulin resistance according to a minimal model analysis</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>53</volume><issue>9</issue><spage>1095</spage><epage>1100</epage><pages>1095-1100</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>We investigated effects of weight loss from diet and exercise regimen in obese subjects with normal fasting plasma glucose or impaired glucose tolerance (IGT) on insulin release capacity and insulin sensitivity. Eight subjects were recruited among visceral obesity patients (4 men, 4 women; age range, 24 to 57 years; body mass index [BMI], 32.8 to 60.3 kg/m
2). All were admitted to Chiba University Hospital for 2 weeks, were treated with a tapering 5,023 to 2,930 kJ diet, and were given exercise equivalent to 628 kJ/d. For assessments, we used a combination of C-peptide secretion rate determination and minimal model analysis as previously reported. BMI and visceral fat area (V) significantly decreased (BMI on initiation
v after intervention, 43.0 ± 3.2
v 40.3 ± 3.1 kg/m
2,
P < .05; V, 224 ± 22
v 188 ± 22 cm
2;
P < .05). Fasting immunoreactive insulin (F-IRI) and leptin concentrations decreased significantly. Capacity for insulin release in response to glucose increased in all subjects (first-phase insulin secretion [CS1], 4.66 ± 4.05
v 6.81 ± 4.57 ng/mL/5 min,
P < .05), but the insulin sensitivity index (S
i) did not change significantly. These data suggest that weight reduction early in development of type 2 diabetes can oppose progression of diabetes by improving capacity for insulin release.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15334366</pmid><doi>10.1016/j.metabol.2004.04.002</doi><tpages>6</tpages></addata></record> |
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| subjects | Adipose Tissue - physiology Adult Biological and medical sciences Blood Glucose - metabolism Body Mass Index C-Peptide - metabolism Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Exercise Therapy Female Glucose Intolerance - metabolism Humans Insulin - blood Insulin - metabolism Insulin Resistance - physiology Lipids - blood Male Medical sciences Middle Aged Models, Biological Obesity - diet therapy Obesity - physiopathology Obesity - therapy Weight Loss - physiology |
| title | Effects of weight loss in obese subjects with normal fasting plasma glucose or impaired glucose tolerance on insulin release and insulin resistance according to a minimal model analysis |
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