Low concentrations of maternal thyroxin during early gestation: a risk factor of breech presentation?
Objective To evaluate the relation between breech position at term (>37 weeks of gestation) and low maternal fT4 levels during gestation in women not suffering from overt thyroid dysfunction. Design A prospective cohort study of pregnant women. Setting Community‐based study. Population/Sample ...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 2004-09, Vol.111 (9), p.925-930 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
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| creator | Pop, Victor J. Brouwers, Evelien P. Wijnen, Hennie Oei, Guid Essed, Gerard G. Vader, Huib L. |
| description | Objective To evaluate the relation between breech position at term (>37 weeks of gestation) and low maternal fT4 levels during gestation in women not suffering from overt thyroid dysfunction.
Design A prospective cohort study of pregnant women.
Setting Community‐based study.
Population/Sample At random selected pregnant women of the general population.
Methods At antenatal booking, based on thyroid function assessed at 12 weeks of gestation in a large cohort of pregnant women, two groups of participants were defined: women with low fT4 levels—below the 10th centile (n= 135) and women with fT4—between the 50th and 90th centiles at 12 weeks of gestation (n= 135). Women with clinical thyroid dysfunction (fT4 and TSH outside reference range) at 12 weeks of gestation were excluded. Maternal thyroid function (fT4 and TSH) was subsequently assessed at 24 and 32 weeks of gestation. Analysis refers to 204 women who met the inclusion and exclusion criteria and in whom all thyroid parameters were assessed.
Main outcome measures Fetal presentation (cephalic–breech) at delivery in women with term gestation (>37 weeks of gestation) in relation to maternal thyroid function at 12, 24 and 34 weeks of gestation.
Results Breech presentation at term delivery was independently related to fT4 levels 37 weeks of gestation). |
| doi_str_mv | 10.1111/j.1471-0528.2004.00213.x |
| format | Article |
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Design A prospective cohort study of pregnant women.
Setting Community‐based study.
Population/Sample At random selected pregnant women of the general population.
Methods At antenatal booking, based on thyroid function assessed at 12 weeks of gestation in a large cohort of pregnant women, two groups of participants were defined: women with low fT4 levels—below the 10th centile (n= 135) and women with fT4—between the 50th and 90th centiles at 12 weeks of gestation (n= 135). Women with clinical thyroid dysfunction (fT4 and TSH outside reference range) at 12 weeks of gestation were excluded. Maternal thyroid function (fT4 and TSH) was subsequently assessed at 24 and 32 weeks of gestation. Analysis refers to 204 women who met the inclusion and exclusion criteria and in whom all thyroid parameters were assessed.
Main outcome measures Fetal presentation (cephalic–breech) at delivery in women with term gestation (>37 weeks of gestation) in relation to maternal thyroid function at 12, 24 and 34 weeks of gestation.
Results Breech presentation at term delivery was independently related to fT4 levels <10th centile at 12 weeks of gestation (OR = 4.7, 95% CI 1.1–19 [but not to an fT4 level below the 10th centile at 24 and 32 weeks of gestation]) as well as primiparity (OR = 4.7, 95% CI 1.3–15).
Conclusions Women with hypothyroxinaemia (fT4 level at the lowest 10th centile) during early gestation but without overt thyroid function are at risk for fetal breech presentation at term (>37 weeks of gestation).</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/j.1471-0528.2004.00213.x</identifier><identifier>PMID: 15327606</identifier><language>eng</language><publisher>Oxford, UK and Malden, USA: Blackwell Science Ltd</publisher><subject>Biological and medical sciences ; Biomarkers - blood ; Breech Presentation ; Cohort Studies ; Female ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Hypothyroidism - blood ; Medical sciences ; Obstetric Labor Complications - blood ; Obstetric Labor Complications - etiology ; Pregnancy ; Prospective Studies ; Regression Analysis ; Risk Factors ; Socioeconomic Factors ; Thyroxine - blood ; Thyroxine - deficiency</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2004-09, Vol.111 (9), p.925-930</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4463-674590c6bf073ad191403d79ed6cce0ec3e24b65307fc071242d5e8c93573acf3</citedby><cites>FETCH-LOGICAL-c4463-674590c6bf073ad191403d79ed6cce0ec3e24b65307fc071242d5e8c93573acf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-0528.2004.00213.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-0528.2004.00213.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16069595$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15327606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pop, Victor J.</creatorcontrib><creatorcontrib>Brouwers, Evelien P.</creatorcontrib><creatorcontrib>Wijnen, Hennie</creatorcontrib><creatorcontrib>Oei, Guid</creatorcontrib><creatorcontrib>Essed, Gerard G.</creatorcontrib><creatorcontrib>Vader, Huib L.</creatorcontrib><title>Low concentrations of maternal thyroxin during early gestation: a risk factor of breech presentation?</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Objective To evaluate the relation between breech position at term (>37 weeks of gestation) and low maternal fT4 levels during gestation in women not suffering from overt thyroid dysfunction.
Design A prospective cohort study of pregnant women.
Setting Community‐based study.
Population/Sample At random selected pregnant women of the general population.
Methods At antenatal booking, based on thyroid function assessed at 12 weeks of gestation in a large cohort of pregnant women, two groups of participants were defined: women with low fT4 levels—below the 10th centile (n= 135) and women with fT4—between the 50th and 90th centiles at 12 weeks of gestation (n= 135). Women with clinical thyroid dysfunction (fT4 and TSH outside reference range) at 12 weeks of gestation were excluded. Maternal thyroid function (fT4 and TSH) was subsequently assessed at 24 and 32 weeks of gestation. Analysis refers to 204 women who met the inclusion and exclusion criteria and in whom all thyroid parameters were assessed.
Main outcome measures Fetal presentation (cephalic–breech) at delivery in women with term gestation (>37 weeks of gestation) in relation to maternal thyroid function at 12, 24 and 34 weeks of gestation.
Results Breech presentation at term delivery was independently related to fT4 levels <10th centile at 12 weeks of gestation (OR = 4.7, 95% CI 1.1–19 [but not to an fT4 level below the 10th centile at 24 and 32 weeks of gestation]) as well as primiparity (OR = 4.7, 95% CI 1.3–15).
Conclusions Women with hypothyroxinaemia (fT4 level at the lowest 10th centile) during early gestation but without overt thyroid function are at risk for fetal breech presentation at term (>37 weeks of gestation).</description><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Breech Presentation</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hypothyroidism - blood</subject><subject>Medical sciences</subject><subject>Obstetric Labor Complications - blood</subject><subject>Obstetric Labor Complications - etiology</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Socioeconomic Factors</subject><subject>Thyroxine - blood</subject><subject>Thyroxine - deficiency</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0Eorx-AXkDu4SxnTgJCxAgnqrEBtaW60xKShoXOxXt3-OkFWyZzYzkc8ejQwhlELNQF7OYJRmLIOV5zAGSGIAzEa92yMHvw-4wQwSC5yNy6P0MgEkOYp-MWCp4JkEeEBzbb2psa7DtnO5q23pqKzrXHbpWN7T7WDu7qltaLl3dTilq16zpFH03wJdUU1f7T1pp01nXRycO0XzQhUMfdg7U9THZq3Tj8WTbj8j7w_3b3VM0fn18vrsZRyZJpIhklqQFGDmpIBO6ZAVLQJRZgaU0BgGNQJ5MZCogqwxkjCe8TDE3hUgDbypxRM43exfOfi3DkWpee4NNo1u0S6-kzFkuGQtgvgGNs947rNTC1XPt1oqB6hWrmepNqt6k6hWrQbFahejp9o_lZI7lX3DrNABnW0B7o5vK6dbU_o8LTJEWaeCuNtx33eD63weo25fXYRQ_uSmYBA</recordid><startdate>200409</startdate><enddate>200409</enddate><creator>Pop, Victor J.</creator><creator>Brouwers, Evelien P.</creator><creator>Wijnen, Hennie</creator><creator>Oei, Guid</creator><creator>Essed, Gerard G.</creator><creator>Vader, Huib L.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200409</creationdate><title>Low concentrations of maternal thyroxin during early gestation: a risk factor of breech presentation?</title><author>Pop, Victor J. ; Brouwers, Evelien P. ; Wijnen, Hennie ; Oei, Guid ; Essed, Gerard G. ; Vader, Huib L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4463-674590c6bf073ad191403d79ed6cce0ec3e24b65307fc071242d5e8c93573acf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Breech Presentation</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hypothyroidism - blood</topic><topic>Medical sciences</topic><topic>Obstetric Labor Complications - blood</topic><topic>Obstetric Labor Complications - etiology</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Socioeconomic Factors</topic><topic>Thyroxine - blood</topic><topic>Thyroxine - deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pop, Victor J.</creatorcontrib><creatorcontrib>Brouwers, Evelien P.</creatorcontrib><creatorcontrib>Wijnen, Hennie</creatorcontrib><creatorcontrib>Oei, Guid</creatorcontrib><creatorcontrib>Essed, Gerard G.</creatorcontrib><creatorcontrib>Vader, Huib L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pop, Victor J.</au><au>Brouwers, Evelien P.</au><au>Wijnen, Hennie</au><au>Oei, Guid</au><au>Essed, Gerard G.</au><au>Vader, Huib L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low concentrations of maternal thyroxin during early gestation: a risk factor of breech presentation?</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2004-09</date><risdate>2004</risdate><volume>111</volume><issue>9</issue><spage>925</spage><epage>930</epage><pages>925-930</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><abstract>Objective To evaluate the relation between breech position at term (>37 weeks of gestation) and low maternal fT4 levels during gestation in women not suffering from overt thyroid dysfunction.
Design A prospective cohort study of pregnant women.
Setting Community‐based study.
Population/Sample At random selected pregnant women of the general population.
Methods At antenatal booking, based on thyroid function assessed at 12 weeks of gestation in a large cohort of pregnant women, two groups of participants were defined: women with low fT4 levels—below the 10th centile (n= 135) and women with fT4—between the 50th and 90th centiles at 12 weeks of gestation (n= 135). Women with clinical thyroid dysfunction (fT4 and TSH outside reference range) at 12 weeks of gestation were excluded. Maternal thyroid function (fT4 and TSH) was subsequently assessed at 24 and 32 weeks of gestation. Analysis refers to 204 women who met the inclusion and exclusion criteria and in whom all thyroid parameters were assessed.
Main outcome measures Fetal presentation (cephalic–breech) at delivery in women with term gestation (>37 weeks of gestation) in relation to maternal thyroid function at 12, 24 and 34 weeks of gestation.
Results Breech presentation at term delivery was independently related to fT4 levels <10th centile at 12 weeks of gestation (OR = 4.7, 95% CI 1.1–19 [but not to an fT4 level below the 10th centile at 24 and 32 weeks of gestation]) as well as primiparity (OR = 4.7, 95% CI 1.3–15).
Conclusions Women with hypothyroxinaemia (fT4 level at the lowest 10th centile) during early gestation but without overt thyroid function are at risk for fetal breech presentation at term (>37 weeks of gestation).</abstract><cop>Oxford, UK and Malden, USA</cop><pub>Blackwell Science Ltd</pub><pmid>15327606</pmid><doi>10.1111/j.1471-0528.2004.00213.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BJOG : an international journal of obstetrics and gynaecology, 2004-09, Vol.111 (9), p.925-930 |
| issn | 1470-0328 1471-0528 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biological and medical sciences Biomarkers - blood Breech Presentation Cohort Studies Female Gestational Age Gynecology. Andrology. Obstetrics Humans Hypothyroidism - blood Medical sciences Obstetric Labor Complications - blood Obstetric Labor Complications - etiology Pregnancy Prospective Studies Regression Analysis Risk Factors Socioeconomic Factors Thyroxine - blood Thyroxine - deficiency |
| title | Low concentrations of maternal thyroxin during early gestation: a risk factor of breech presentation? |
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