A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci

BACKGROUND Nonsyndromic cleft lip with or without cleft palate, CL(P), is a common human birth defect with a complex unknown genetic cause. The mouse model is the “A/∼” strains. Our previous studies mapped two loci: clf1 on Chr11 and clf2 on Chr13—with a strong genetic maternal effect on the level o...

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Veröffentlicht in:	Birth defects research. A Clinical and molecular teratology 2004-08, Vol.70 (8), p.509-518
Hauptverfasser:	Juriloff, Diana M., Harris, Muriel J., Dewell, Sarah L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Chromosome Mapping cleft lip Cleft Lip - genetics cleft palate congenic Crosses, Genetic digenic Disease Models, Animal DNA Primers Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Male Mice Mice, Inbred A - genetics Mice, Inbred C57BL - genetics mouse multifactorial Polymerase Chain Reaction Polymorphism, Genetic Teratology. Teratogens
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