Argos inhibits epidermal growth factor receptor signalling by ligand sequestration

The epidermal growth factor receptor (EGFR) has critical functions in development and in many human cancers. During development, the spatial extent of EGFR signalling is regulated by feedback loops comprising both well-understood activators and less well-characterized inhibitors. In Drosophila melan...

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Veröffentlicht in:	Nature (London) 2004-08, Vol.430 (7003), p.1040-1044
Hauptverfasser:	Klein, D.E, Nappi, V.M, Reeves, G.T, Shvartsman, S.Y, Lemmon, M.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents binding proteins Binding Sites Biochemistry Biological and medical sciences Cancer Developmental stages Down-Regulation Drosophila melanogaster Drosophila melanogaster - metabolism Drosophila Proteins - antagonists & inhibitors Drosophila Proteins - metabolism Electron Spin Resonance Spectroscopy epidermal growth factor Epidermal Growth Factor - antagonists & inhibitors Epidermal Growth Factor - metabolism ErbB Receptors - antagonists & inhibitors ErbB Receptors - metabolism Eye Proteins - metabolism General aspects Humanities and Social Sciences letter Ligands Medical sciences Membrane Proteins - antagonists & inhibitors Membrane Proteins - metabolism multidisciplinary Nerve Tissue Proteins - metabolism Pharmacology. Drug treatments Protein Binding Protein Kinase Inhibitors Protein Kinases - metabolism Proteins receptors Receptors, Invertebrate Peptide - antagonists & inhibitors Receptors, Invertebrate Peptide - metabolism Science Science (multidisciplinary) Signal Transduction
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