Chromosomal Protein HMGN1 Modulates Histone H3 Phosphorylation

Here we demonstrate that HMGN1, a nuclear protein that binds to nucleosomes and reduces the compaction of the chromatin fiber, modulates histone posttranslational modifications. In Hmgn1−/− cells, loss of HMGN1 elevates the steady-state levels of phospho-S10-H3 and enhances the rate of stress-induce...

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Veröffentlicht in:	Molecular cell 2004-08, Vol.15 (4), p.573-584
Hauptverfasser:	Lim, Jae-Hwan, Catez, Frédéric, Birger, Yehudit, West, Katherine L., Prymakowska-Bosak, Marta, Postnikov, Yuri V., Bustin, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anisomycin - pharmacology Cells, Cultured Chromatin - metabolism Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - physiology Gene Expression Regulation Genes, Immediate-Early Histones - metabolism HMGN1 Protein - genetics HMGN1 Protein - metabolism Mice Mice, Knockout Nucleosomes - metabolism Phosphorylation Protein Binding Protein Processing, Post-Translational Protein Synthesis Inhibitors - pharmacology
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