Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans

In animals, systemic and intrathecal administration of the alpha2 -adrenergic receptor agonist dexmedetomidine results in robust antinociceptive effects in models of heat pain. In humans, systemically administered dexmedetomidine is approved for sedating patients in the intensive care unit. However,...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2004-09, Vol.101 (3), p.744-752
Hauptverfasser:	ANGST, Martin S, RAMASWAMY, Bhamini, DAVIES, M. Frances, MAZE, Mervyn
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - blood Adrenergic alpha-Agonists - pharmacology Adult Alfentanil - blood Alfentanil - pharmacology Analgesics, Non-Narcotic - blood Analgesics, Non-Narcotic - pharmacology Analgesics, Opioid - blood Analgesics, Opioid - pharmacology Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Dexmedetomidine - blood Dexmedetomidine - pharmacology Dose-Response Relationship, Drug Double-Blind Method Electric Stimulation Female Gas Chromatography-Mass Spectrometry Hemodynamics - drug effects Hot Temperature Humans Hypnotics and Sedatives - pharmacology Infusions, Intravenous Male Medical sciences Mental Processes - drug effects Neuropsychological Tests Pain Measurement - drug effects Reaction Time - drug effects
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