Effect of different induction strategies on effector, regulatory and memory lymphocyte sub‐populations in clinical islet transplantation
Summary This prospective study assessed lymphocyte subsets in the peripheral blood of 42 islet allograft recipients using flow cytometry from 2 weeks and up to 2 years post‐transplantation. Subjects received daclizumab (n = 16), Thymoglobulin (n = 12) or alemtuzumab (n = 14). Alemtuzumab was associa...
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| Veröffentlicht in: | Transplant international 2009-02, Vol.22 (2), p.182-191 |
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| container_title | Transplant international |
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| creator | Toso, Christian Edgar, Ryan Pawlick, Rena Emamaullee, Juliet Merani, Shaheed Dinyari, Parastoo Mueller, Thomas F. Shapiro, A. M. James Anderson, Colin C. |
| description | Summary
This prospective study assessed lymphocyte subsets in the peripheral blood of 42 islet allograft recipients using flow cytometry from 2 weeks and up to 2 years post‐transplantation. Subjects received daclizumab (n = 16), Thymoglobulin (n = 12) or alemtuzumab (n = 14). Alemtuzumab was associated with an early (within 1 month) and transient (up to 6 months) increase in the frequency of CD3+ CD4+ Foxp3+ T cells, while daclizumab induced a near complete loss of these cells (P ≤ 0.001). The frequency of memory CD4+ T cells was increased following depleting immunosuppression induction with either Thymoglobulin or alemtuzumab (P ≤ 0.05), but remained unchanged while using daclizumab. Alemtuzumab induction resulted in a significant loss of memory B lymphocytes when compared with the other induction groups (P ≤ 0.001). While the clinical significance of these findings remains to be fully determined, the observed altered balance between effector, regulatory and memory cells suggests that the immune status of patients will be affected according to the induction strategy chosen. |
| doi_str_mv | 10.1111/j.1432-2277.2008.00746.x |
| format | Article |
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This prospective study assessed lymphocyte subsets in the peripheral blood of 42 islet allograft recipients using flow cytometry from 2 weeks and up to 2 years post‐transplantation. Subjects received daclizumab (n = 16), Thymoglobulin (n = 12) or alemtuzumab (n = 14). Alemtuzumab was associated with an early (within 1 month) and transient (up to 6 months) increase in the frequency of CD3+ CD4+ Foxp3+ T cells, while daclizumab induced a near complete loss of these cells (P ≤ 0.001). The frequency of memory CD4+ T cells was increased following depleting immunosuppression induction with either Thymoglobulin or alemtuzumab (P ≤ 0.05), but remained unchanged while using daclizumab. Alemtuzumab induction resulted in a significant loss of memory B lymphocytes when compared with the other induction groups (P ≤ 0.001). While the clinical significance of these findings remains to be fully determined, the observed altered balance between effector, regulatory and memory cells suggests that the immune status of patients will be affected according to the induction strategy chosen.</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1111/j.1432-2277.2008.00746.x</identifier><identifier>PMID: 18713144</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Alemtuzumab ; Antibodies, Monoclonal - pharmacology ; Antibodies, Monoclonal, Humanized ; Antibodies, Neoplasm - pharmacology ; Antilymphocyte Serum ; CD4 antigen ; Female ; Flow Cytometry ; Humans ; Immune status ; Immunoglobulin G - pharmacology ; Immunological memory ; Immunosuppression ; Immunosuppressive Agents - pharmacology ; islet ; Islet cells ; Islets of Langerhans Transplantation - immunology ; lymphocyte ; Lymphocyte Subsets - drug effects ; Lymphocyte Subsets - immunology ; Lymphocytes B ; Lymphocytes T ; Male ; memory ; Memory cells ; Middle Aged ; Monoclonal antibodies ; Pancreatic islet transplantation ; Peripheral blood ; Prospective Studies ; regulatory ; thymoglobulin ; Transplantation</subject><ispartof>Transplant international, 2009-02, Vol.22 (2), p.182-191</ispartof><rights>2008 The Authors. Journal compilation © 2008 European Society for Organ Transplantation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3816-e57a7f48d2ed127b741acdff252d50efe42662e1742e95b6caa69457ef44ae933</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1432-2277.2008.00746.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1432-2277.2008.00746.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18713144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Toso, Christian</creatorcontrib><creatorcontrib>Edgar, Ryan</creatorcontrib><creatorcontrib>Pawlick, Rena</creatorcontrib><creatorcontrib>Emamaullee, Juliet</creatorcontrib><creatorcontrib>Merani, Shaheed</creatorcontrib><creatorcontrib>Dinyari, Parastoo</creatorcontrib><creatorcontrib>Mueller, Thomas F.</creatorcontrib><creatorcontrib>Shapiro, A. M. James</creatorcontrib><creatorcontrib>Anderson, Colin C.</creatorcontrib><title>Effect of different induction strategies on effector, regulatory and memory lymphocyte sub‐populations in clinical islet transplantation</title><title>Transplant international</title><addtitle>Transpl Int</addtitle><description>Summary
This prospective study assessed lymphocyte subsets in the peripheral blood of 42 islet allograft recipients using flow cytometry from 2 weeks and up to 2 years post‐transplantation. Subjects received daclizumab (n = 16), Thymoglobulin (n = 12) or alemtuzumab (n = 14). Alemtuzumab was associated with an early (within 1 month) and transient (up to 6 months) increase in the frequency of CD3+ CD4+ Foxp3+ T cells, while daclizumab induced a near complete loss of these cells (P ≤ 0.001). The frequency of memory CD4+ T cells was increased following depleting immunosuppression induction with either Thymoglobulin or alemtuzumab (P ≤ 0.05), but remained unchanged while using daclizumab. Alemtuzumab induction resulted in a significant loss of memory B lymphocytes when compared with the other induction groups (P ≤ 0.001). While the clinical significance of these findings remains to be fully determined, the observed altered balance between effector, regulatory and memory cells suggests that the immune status of patients will be affected according to the induction strategy chosen.</description><subject>Alemtuzumab</subject><subject>Antibodies, Monoclonal - pharmacology</subject><subject>Antibodies, Monoclonal, Humanized</subject><subject>Antibodies, Neoplasm - pharmacology</subject><subject>Antilymphocyte Serum</subject><subject>CD4 antigen</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Immune status</subject><subject>Immunoglobulin G - pharmacology</subject><subject>Immunological memory</subject><subject>Immunosuppression</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>islet</subject><subject>Islet cells</subject><subject>Islets of Langerhans Transplantation - immunology</subject><subject>lymphocyte</subject><subject>Lymphocyte Subsets - drug effects</subject><subject>Lymphocyte Subsets - immunology</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>memory</subject><subject>Memory cells</subject><subject>Middle Aged</subject><subject>Monoclonal antibodies</subject><subject>Pancreatic islet transplantation</subject><subject>Peripheral blood</subject><subject>Prospective Studies</subject><subject>regulatory</subject><subject>thymoglobulin</subject><subject>Transplantation</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhkOxtNfqX5CsxEVnzNckM-BGStVCQSjtOuRmTmoumQ8nGdrZde3K3-gvMXNbdWezyRvOw3sCD0KYkpLm835XUsFZwZhSJSOkLglRQpb3B2jzd_ACbUjDRUFqJY7Ryxh3hBBWV-QIHdNaUU6F2KAf586BTXhwuPU5TtAn7Pt2tskPPY5pMgluPUScX7Bnh-kUT3A7B5Pjgk3f4g66NYalG78NdkmA47z99fBzHMYVy00xl2IbfO-tCdjHAAnn7j6OwfRpj7xCh86ECK-f7hN08-n8-uxLcfn188XZx8vC8prKAipllBN1y6ClTG2VoMa2zrGKtRUBB4JJyYAqwaCpttIaIxtRKXBCGGg4P0FvH3vHafg-Q0y689FCyB-BYY5ayrymUc-DjHAiai4z-O6_IGWMUkFVU2f0zRM6bzto9Tj5zkyL_mMkAx8egTsfYPk3J3o1r3d6FaxXwXo1r_fm9b2-vrrIgf8G6yullQ</recordid><startdate>200902</startdate><enddate>200902</enddate><creator>Toso, Christian</creator><creator>Edgar, Ryan</creator><creator>Pawlick, Rena</creator><creator>Emamaullee, Juliet</creator><creator>Merani, Shaheed</creator><creator>Dinyari, Parastoo</creator><creator>Mueller, Thomas F.</creator><creator>Shapiro, A. M. James</creator><creator>Anderson, Colin C.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200902</creationdate><title>Effect of different induction strategies on effector, regulatory and memory lymphocyte sub‐populations in clinical islet transplantation</title><author>Toso, Christian ; Edgar, Ryan ; Pawlick, Rena ; Emamaullee, Juliet ; Merani, Shaheed ; Dinyari, Parastoo ; Mueller, Thomas F. ; Shapiro, A. M. James ; Anderson, Colin C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3816-e57a7f48d2ed127b741acdff252d50efe42662e1742e95b6caa69457ef44ae933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Alemtuzumab</topic><topic>Antibodies, Monoclonal - pharmacology</topic><topic>Antibodies, Monoclonal, Humanized</topic><topic>Antibodies, Neoplasm - pharmacology</topic><topic>Antilymphocyte Serum</topic><topic>CD4 antigen</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Immune status</topic><topic>Immunoglobulin G - pharmacology</topic><topic>Immunological memory</topic><topic>Immunosuppression</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>islet</topic><topic>Islet cells</topic><topic>Islets of Langerhans Transplantation - immunology</topic><topic>lymphocyte</topic><topic>Lymphocyte Subsets - drug effects</topic><topic>Lymphocyte Subsets - immunology</topic><topic>Lymphocytes B</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>memory</topic><topic>Memory cells</topic><topic>Middle Aged</topic><topic>Monoclonal antibodies</topic><topic>Pancreatic islet transplantation</topic><topic>Peripheral blood</topic><topic>Prospective Studies</topic><topic>regulatory</topic><topic>thymoglobulin</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toso, Christian</creatorcontrib><creatorcontrib>Edgar, Ryan</creatorcontrib><creatorcontrib>Pawlick, Rena</creatorcontrib><creatorcontrib>Emamaullee, Juliet</creatorcontrib><creatorcontrib>Merani, Shaheed</creatorcontrib><creatorcontrib>Dinyari, Parastoo</creatorcontrib><creatorcontrib>Mueller, Thomas F.</creatorcontrib><creatorcontrib>Shapiro, A. M. James</creatorcontrib><creatorcontrib>Anderson, Colin C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toso, Christian</au><au>Edgar, Ryan</au><au>Pawlick, Rena</au><au>Emamaullee, Juliet</au><au>Merani, Shaheed</au><au>Dinyari, Parastoo</au><au>Mueller, Thomas F.</au><au>Shapiro, A. M. James</au><au>Anderson, Colin C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of different induction strategies on effector, regulatory and memory lymphocyte sub‐populations in clinical islet transplantation</atitle><jtitle>Transplant international</jtitle><addtitle>Transpl Int</addtitle><date>2009-02</date><risdate>2009</risdate><volume>22</volume><issue>2</issue><spage>182</spage><epage>191</epage><pages>182-191</pages><issn>0934-0874</issn><eissn>1432-2277</eissn><abstract>Summary
This prospective study assessed lymphocyte subsets in the peripheral blood of 42 islet allograft recipients using flow cytometry from 2 weeks and up to 2 years post‐transplantation. Subjects received daclizumab (n = 16), Thymoglobulin (n = 12) or alemtuzumab (n = 14). Alemtuzumab was associated with an early (within 1 month) and transient (up to 6 months) increase in the frequency of CD3+ CD4+ Foxp3+ T cells, while daclizumab induced a near complete loss of these cells (P ≤ 0.001). The frequency of memory CD4+ T cells was increased following depleting immunosuppression induction with either Thymoglobulin or alemtuzumab (P ≤ 0.05), but remained unchanged while using daclizumab. Alemtuzumab induction resulted in a significant loss of memory B lymphocytes when compared with the other induction groups (P ≤ 0.001). While the clinical significance of these findings remains to be fully determined, the observed altered balance between effector, regulatory and memory cells suggests that the immune status of patients will be affected according to the induction strategy chosen.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18713144</pmid><doi>10.1111/j.1432-2277.2008.00746.x</doi><tpages>10</tpages></addata></record> |
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| ispartof | Transplant international, 2009-02, Vol.22 (2), p.182-191 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals |
| subjects | Alemtuzumab Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal, Humanized Antibodies, Neoplasm - pharmacology Antilymphocyte Serum CD4 antigen Female Flow Cytometry Humans Immune status Immunoglobulin G - pharmacology Immunological memory Immunosuppression Immunosuppressive Agents - pharmacology islet Islet cells Islets of Langerhans Transplantation - immunology lymphocyte Lymphocyte Subsets - drug effects Lymphocyte Subsets - immunology Lymphocytes B Lymphocytes T Male memory Memory cells Middle Aged Monoclonal antibodies Pancreatic islet transplantation Peripheral blood Prospective Studies regulatory thymoglobulin Transplantation |
| title | Effect of different induction strategies on effector, regulatory and memory lymphocyte sub‐populations in clinical islet transplantation |
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