Transmission of Imported Vaccine-Derived Poliovirus in an Undervaccinated Community in Minnesota
Background.Oral poliovirus vaccine (OPV) has not been used in the United States since 2000. Type 1 vaccinederived poliovirus (VDPV) was identified in September 2005, from an unvaccinated Amish infant hospitalized in Minnesota with severe combined immunodeficiency. An investigation was conducted to d...
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| Veröffentlicht in: | The Journal of infectious diseases 2009-02, Vol.199 (3), p.391-397 |
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| creator | Alexander, James P. Ehresmann, Kristen Seward, Jane Wax, Gary Harriman, Kathleen Fuller, Susan Cebelinski, Elizabeth A. Chen, Qi Kew, Olen M. Pallansch, Mark A. Oberste, M. Steven Schleiss, Mark Davis, Jeffrey P. Warshasky, Bryna Squires, Susan Hull, Harry F. |
| description | Background.Oral poliovirus vaccine (OPV) has not been used in the United States since 2000. Type 1 vaccinederived poliovirus (VDPV) was identified in September 2005, from an unvaccinated Amish infant hospitalized in Minnesota with severe combined immunodeficiency. An investigation was conducted to determine the source of the virus and its means of transmission. Methods. The infant was tested serially for poliovirus excretion. Investigations were conducted to detect poliovirus infections or paralytic poliomyelitis in Amish communities in Minnesota, neighboring states, and Ontario, Canada. Genomic sequences of poliovirus isolates were determined for phylogenetic analysis. Results. No source for the VDPV could be identified. In the index community, 8 (35%) of 23 children tested, including the infant, had evidence of type 1 poliovirus or VDPV infection. Phylogenetic analysis suggested that the VDPV circulated in the community for ∼2 months before the infant's infection was detected and that the initiating OPV dose had been given before her birth. No paralytic disease was found in the community, and no poliovirus infections were found in other Amish communities investigated. Conclusions. This is the first demonstrated transmission of VDPV in an undervaccinated community in a developed country. Continued vigilance is needed in all countries to identify poliovirus infections in communities at high risk of poliovirus transmission. |
| doi_str_mv | 10.1086/596052 |
| format | Article |
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Steven ; Schleiss, Mark ; Davis, Jeffrey P. ; Warshasky, Bryna ; Squires, Susan ; Hull, Harry F.</creator><creatorcontrib>Alexander, James P. ; Ehresmann, Kristen ; Seward, Jane ; Wax, Gary ; Harriman, Kathleen ; Fuller, Susan ; Cebelinski, Elizabeth A. ; Chen, Qi ; Kew, Olen M. ; Pallansch, Mark A. ; Oberste, M. Steven ; Schleiss, Mark ; Davis, Jeffrey P. ; Warshasky, Bryna ; Squires, Susan ; Hull, Harry F. ; Vaccine-Derived Poliovirus Investigations Group ; Vaccine‐Derived Poliovirus Investigations Group</creatorcontrib><description>Background.Oral poliovirus vaccine (OPV) has not been used in the United States since 2000. Type 1 vaccinederived poliovirus (VDPV) was identified in September 2005, from an unvaccinated Amish infant hospitalized in Minnesota with severe combined immunodeficiency. An investigation was conducted to determine the source of the virus and its means of transmission. Methods. The infant was tested serially for poliovirus excretion. Investigations were conducted to detect poliovirus infections or paralytic poliomyelitis in Amish communities in Minnesota, neighboring states, and Ontario, Canada. Genomic sequences of poliovirus isolates were determined for phylogenetic analysis. Results. No source for the VDPV could be identified. In the index community, 8 (35%) of 23 children tested, including the infant, had evidence of type 1 poliovirus or VDPV infection. Phylogenetic analysis suggested that the VDPV circulated in the community for ∼2 months before the infant's infection was detected and that the initiating OPV dose had been given before her birth. No paralytic disease was found in the community, and no poliovirus infections were found in other Amish communities investigated. Conclusions. This is the first demonstrated transmission of VDPV in an undervaccinated community in a developed country. Continued vigilance is needed in all countries to identify poliovirus infections in communities at high risk of poliovirus transmission.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/596052</identifier><identifier>PMID: 19090774</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Oxford: The University of Chicago Press</publisher><subject>Adolescent ; Amino Acid Sequence ; Antigens, Viral - chemistry ; Antigens, Viral - genetics ; Applied microbiology ; Biological and medical sciences ; Bone Marrow Transplantation ; Child, Preschool ; Communities ; Epidemiology ; Feces - virology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunoglobulins, Intravenous - therapeutic use ; Infant ; Infants ; Infections ; Infectious diseases ; Medical sciences ; Microbiology ; Minnesota ; Miscellaneous ; Oral poliovirus vaccine ; Phylogeny ; Polio ; Poliomyelitis - prevention & control ; Poliomyelitis - transmission ; Poliomyelitis - virology ; Poliovirus ; Poliovirus - classification ; Poliovirus - genetics ; Poliovirus - isolation & purification ; Poliovirus Vaccines - administration & dosage ; Poliovirus Vaccines - immunology ; Preventive medicine ; Severe Combined Immunodeficiency - complications ; Severe Combined Immunodeficiency - therapy ; Time Factors ; Vaccination ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Virology ; Viruses</subject><ispartof>The Journal of infectious diseases, 2009-02, Vol.199 (3), p.391-397</ispartof><rights>Copyright 2008 Infectious Diseases Society of America</rights><rights>2009 by the Infectious Diseases Society of America 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-8a9a2148a1dbc5c59e8d819bebc5c3a6245cdef88c9698005476b87f93e452743</citedby><cites>FETCH-LOGICAL-c393t-8a9a2148a1dbc5c59e8d819bebc5c3a6245cdef88c9698005476b87f93e452743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40254431$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40254431$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21050849$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19090774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alexander, James P.</creatorcontrib><creatorcontrib>Ehresmann, Kristen</creatorcontrib><creatorcontrib>Seward, Jane</creatorcontrib><creatorcontrib>Wax, Gary</creatorcontrib><creatorcontrib>Harriman, Kathleen</creatorcontrib><creatorcontrib>Fuller, Susan</creatorcontrib><creatorcontrib>Cebelinski, Elizabeth A.</creatorcontrib><creatorcontrib>Chen, Qi</creatorcontrib><creatorcontrib>Kew, Olen M.</creatorcontrib><creatorcontrib>Pallansch, Mark A.</creatorcontrib><creatorcontrib>Oberste, M. Steven</creatorcontrib><creatorcontrib>Schleiss, Mark</creatorcontrib><creatorcontrib>Davis, Jeffrey P.</creatorcontrib><creatorcontrib>Warshasky, Bryna</creatorcontrib><creatorcontrib>Squires, Susan</creatorcontrib><creatorcontrib>Hull, Harry F.</creatorcontrib><creatorcontrib>Vaccine-Derived Poliovirus Investigations Group</creatorcontrib><creatorcontrib>Vaccine‐Derived Poliovirus Investigations Group</creatorcontrib><title>Transmission of Imported Vaccine-Derived Poliovirus in an Undervaccinated Community in Minnesota</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Background.Oral poliovirus vaccine (OPV) has not been used in the United States since 2000. Type 1 vaccinederived poliovirus (VDPV) was identified in September 2005, from an unvaccinated Amish infant hospitalized in Minnesota with severe combined immunodeficiency. An investigation was conducted to determine the source of the virus and its means of transmission. Methods. The infant was tested serially for poliovirus excretion. Investigations were conducted to detect poliovirus infections or paralytic poliomyelitis in Amish communities in Minnesota, neighboring states, and Ontario, Canada. Genomic sequences of poliovirus isolates were determined for phylogenetic analysis. Results. No source for the VDPV could be identified. In the index community, 8 (35%) of 23 children tested, including the infant, had evidence of type 1 poliovirus or VDPV infection. Phylogenetic analysis suggested that the VDPV circulated in the community for ∼2 months before the infant's infection was detected and that the initiating OPV dose had been given before her birth. No paralytic disease was found in the community, and no poliovirus infections were found in other Amish communities investigated. Conclusions. This is the first demonstrated transmission of VDPV in an undervaccinated community in a developed country. Continued vigilance is needed in all countries to identify poliovirus infections in communities at high risk of poliovirus transmission.</description><subject>Adolescent</subject><subject>Amino Acid Sequence</subject><subject>Antigens, Viral - chemistry</subject><subject>Antigens, Viral - genetics</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation</subject><subject>Child, Preschool</subject><subject>Communities</subject><subject>Epidemiology</subject><subject>Feces - virology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immunoglobulins, Intravenous - therapeutic use</subject><subject>Infant</subject><subject>Infants</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Minnesota</subject><subject>Miscellaneous</subject><subject>Oral poliovirus vaccine</subject><subject>Phylogeny</subject><subject>Polio</subject><subject>Poliomyelitis - prevention & control</subject><subject>Poliomyelitis - transmission</subject><subject>Poliomyelitis - virology</subject><subject>Poliovirus</subject><subject>Poliovirus - classification</subject><subject>Poliovirus - genetics</subject><subject>Poliovirus - isolation & purification</subject><subject>Poliovirus Vaccines - administration & dosage</subject><subject>Poliovirus Vaccines - immunology</subject><subject>Preventive medicine</subject><subject>Severe Combined Immunodeficiency - complications</subject><subject>Severe Combined Immunodeficiency - therapy</subject><subject>Time Factors</subject><subject>Vaccination</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Virology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MtO3DAUBmCrKoIppW8AShftLvQ4vi_R9AKIqoAAVd0Yj-NIhsSe2smovD0ZMhpWXVlH_-dj-UfoA4ZjDJJ_YYoDq96gGWZElJxj8hbNAKqqxFKpPfQu5wcAoISLXbSHFSgQgs7Q_U0yIXc-Zx9DEZvirFvG1Lu6uDPW-uDKry751ThfxtbHlU9DLnwoTChuQ-3S6kWZ9YV57Loh-P5pnf_0Ibgce_Me7TSmze5gc-6j2-_fbuan5cWvH2fzk4vSEkX6UhplKkylwfXCMsuUk7XEauHWEzG8oszWrpHSKq4kAKOCL6RoFHGUVYKSffR52rtM8e_gcq_HT1nXtia4OGTNucScCHiFNsWck2v0MvnOpCeNQa-71FOXIzzabBwWnatf2aa8EXzaAJOtaZuxSevz1lUYGEiqRvdxcnFY_v-xw8k85D6mraJQMUoJHvNyyn3u3b9tbtKj5oIIpk9__9F3l-T86vyaayDPzXOeXg</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Alexander, James P.</creator><creator>Ehresmann, Kristen</creator><creator>Seward, Jane</creator><creator>Wax, Gary</creator><creator>Harriman, Kathleen</creator><creator>Fuller, Susan</creator><creator>Cebelinski, Elizabeth A.</creator><creator>Chen, Qi</creator><creator>Kew, Olen M.</creator><creator>Pallansch, Mark A.</creator><creator>Oberste, M. Steven</creator><creator>Schleiss, Mark</creator><creator>Davis, Jeffrey P.</creator><creator>Warshasky, Bryna</creator><creator>Squires, Susan</creator><creator>Hull, Harry F.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>Transmission of Imported Vaccine-Derived Poliovirus in an Undervaccinated Community in Minnesota</title><author>Alexander, James P. ; Ehresmann, Kristen ; Seward, Jane ; Wax, Gary ; Harriman, Kathleen ; Fuller, Susan ; Cebelinski, Elizabeth A. ; Chen, Qi ; Kew, Olen M. ; Pallansch, Mark A. ; Oberste, M. Steven ; Schleiss, Mark ; Davis, Jeffrey P. ; Warshasky, Bryna ; Squires, Susan ; Hull, Harry F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-8a9a2148a1dbc5c59e8d819bebc5c3a6245cdef88c9698005476b87f93e452743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Amino Acid Sequence</topic><topic>Antigens, Viral - chemistry</topic><topic>Antigens, Viral - genetics</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Transplantation</topic><topic>Child, Preschool</topic><topic>Communities</topic><topic>Epidemiology</topic><topic>Feces - virology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immunoglobulins, Intravenous - therapeutic use</topic><topic>Infant</topic><topic>Infants</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Minnesota</topic><topic>Miscellaneous</topic><topic>Oral poliovirus vaccine</topic><topic>Phylogeny</topic><topic>Polio</topic><topic>Poliomyelitis - prevention & control</topic><topic>Poliomyelitis - transmission</topic><topic>Poliomyelitis - virology</topic><topic>Poliovirus</topic><topic>Poliovirus - classification</topic><topic>Poliovirus - genetics</topic><topic>Poliovirus - isolation & purification</topic><topic>Poliovirus Vaccines - administration & dosage</topic><topic>Poliovirus Vaccines - immunology</topic><topic>Preventive medicine</topic><topic>Severe Combined Immunodeficiency - complications</topic><topic>Severe Combined Immunodeficiency - therapy</topic><topic>Time Factors</topic><topic>Vaccination</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alexander, James P.</creatorcontrib><creatorcontrib>Ehresmann, Kristen</creatorcontrib><creatorcontrib>Seward, Jane</creatorcontrib><creatorcontrib>Wax, Gary</creatorcontrib><creatorcontrib>Harriman, Kathleen</creatorcontrib><creatorcontrib>Fuller, Susan</creatorcontrib><creatorcontrib>Cebelinski, Elizabeth A.</creatorcontrib><creatorcontrib>Chen, Qi</creatorcontrib><creatorcontrib>Kew, Olen M.</creatorcontrib><creatorcontrib>Pallansch, Mark A.</creatorcontrib><creatorcontrib>Oberste, M. Steven</creatorcontrib><creatorcontrib>Schleiss, Mark</creatorcontrib><creatorcontrib>Davis, Jeffrey P.</creatorcontrib><creatorcontrib>Warshasky, Bryna</creatorcontrib><creatorcontrib>Squires, Susan</creatorcontrib><creatorcontrib>Hull, Harry F.</creatorcontrib><creatorcontrib>Vaccine-Derived Poliovirus Investigations Group</creatorcontrib><creatorcontrib>Vaccine‐Derived Poliovirus Investigations Group</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alexander, James P.</au><au>Ehresmann, Kristen</au><au>Seward, Jane</au><au>Wax, Gary</au><au>Harriman, Kathleen</au><au>Fuller, Susan</au><au>Cebelinski, Elizabeth A.</au><au>Chen, Qi</au><au>Kew, Olen M.</au><au>Pallansch, Mark A.</au><au>Oberste, M. Steven</au><au>Schleiss, Mark</au><au>Davis, Jeffrey P.</au><au>Warshasky, Bryna</au><au>Squires, Susan</au><au>Hull, Harry F.</au><aucorp>Vaccine-Derived Poliovirus Investigations Group</aucorp><aucorp>Vaccine‐Derived Poliovirus Investigations Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transmission of Imported Vaccine-Derived Poliovirus in an Undervaccinated Community in Minnesota</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>199</volume><issue>3</issue><spage>391</spage><epage>397</epage><pages>391-397</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Background.Oral poliovirus vaccine (OPV) has not been used in the United States since 2000. Type 1 vaccinederived poliovirus (VDPV) was identified in September 2005, from an unvaccinated Amish infant hospitalized in Minnesota with severe combined immunodeficiency. An investigation was conducted to determine the source of the virus and its means of transmission. Methods. The infant was tested serially for poliovirus excretion. Investigations were conducted to detect poliovirus infections or paralytic poliomyelitis in Amish communities in Minnesota, neighboring states, and Ontario, Canada. Genomic sequences of poliovirus isolates were determined for phylogenetic analysis. Results. No source for the VDPV could be identified. In the index community, 8 (35%) of 23 children tested, including the infant, had evidence of type 1 poliovirus or VDPV infection. Phylogenetic analysis suggested that the VDPV circulated in the community for ∼2 months before the infant's infection was detected and that the initiating OPV dose had been given before her birth. No paralytic disease was found in the community, and no poliovirus infections were found in other Amish communities investigated. Conclusions. This is the first demonstrated transmission of VDPV in an undervaccinated community in a developed country. Continued vigilance is needed in all countries to identify poliovirus infections in communities at high risk of poliovirus transmission.</abstract><cop>Oxford</cop><pub>The University of Chicago Press</pub><pmid>19090774</pmid><doi>10.1086/596052</doi><tpages>7</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 2009-02, Vol.199 (3), p.391-397 |
| issn | 0022-1899 1537-6613 |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Amino Acid Sequence Antigens, Viral - chemistry Antigens, Viral - genetics Applied microbiology Biological and medical sciences Bone Marrow Transplantation Child, Preschool Communities Epidemiology Feces - virology Female Fundamental and applied biological sciences. Psychology Humans Immunoglobulins, Intravenous - therapeutic use Infant Infants Infections Infectious diseases Medical sciences Microbiology Minnesota Miscellaneous Oral poliovirus vaccine Phylogeny Polio Poliomyelitis - prevention & control Poliomyelitis - transmission Poliomyelitis - virology Poliovirus Poliovirus - classification Poliovirus - genetics Poliovirus - isolation & purification Poliovirus Vaccines - administration & dosage Poliovirus Vaccines - immunology Preventive medicine Severe Combined Immunodeficiency - complications Severe Combined Immunodeficiency - therapy Time Factors Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virology Viruses |
| title | Transmission of Imported Vaccine-Derived Poliovirus in an Undervaccinated Community in Minnesota |
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