Direct Carbon Detection in Paramagnetic Metalloproteins To Further Exploit Pseudocontact Shift Restraints

Direct detection heteronuclear NMR allows us to drastically reduce paramagnetic contributions to the line width as compared to 1H detection. As an example, a calcium binding protein (human oncomodulin), in which one of the calcium ions was selectively substituted with Tb3+, is used. Through a variet...

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Veröffentlicht in:	Journal of the American Chemical Society 2004-09, Vol.126 (34), p.10496-10497
Hauptverfasser:	Babini, Elena, Bertini, Ivano, Capozzi, Francesco, Felli, Isabella C, Lelli, Moreno, Luchinat, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Calcium - chemistry Calcium-Binding Proteins - chemistry Carbon Isotopes Fundamental and applied biological sciences. Psychology Humans Lanthanum - chemistry Metalloproteins - chemistry Molecular biophysics Nuclear Magnetic Resonance, Biomolecular - methods Spectroscopy : techniques and spectras Terbium - chemistry
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