A preliminary study of increased amygdala activation to positive affective stimuli in mania
Objectives: The present study in hypomanic and manic patients explored how amygdala responses to affective stimuli depend on the valence of the stimuli presented. Methods: We compared 10 patients with 10 matched healthy control subjects. We measured blood oxygen level‐dependent (BOLD) responses in...
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| Veröffentlicht in: | Bipolar disorders 2009-02, Vol.11 (1), p.70-75 |
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| creator | Bermpohl, Felix Dalanay, Umut Kahnt, Thorsten Sajonz, Bastian Heimann, Hannah Ricken, Roland Stoy, Meline Hägele, Claudia Schlagenhauf, Florian Adli, Mazda Wrase, Jana Ströhle, Andreas Heinz, Andreas Bauer, Michael |
| description | Objectives: The present study in hypomanic and manic patients explored how amygdala responses to affective stimuli depend on the valence of the stimuli presented.
Methods: We compared 10 patients with 10 matched healthy control subjects. We measured blood oxygen level‐dependent (BOLD) responses in the amygdala while subjects passively viewed photographs taken from the International Affective Picture System. After the fMRI session, subjects saw the pictures again and subjectively rated the emotional valence and intensity of each picture.
Results: Compared to healthy individuals, hypomanic or manic patients showed higher valence ratings in positive pictures and associated larger BOLD responses in the left amygdala during positive versus neutral picture viewing. This enhanced amygdala activation was correlated with Young Mania Rating Scale scores and with euphoric as opposed to irritable symptom presentation.
Conclusions: Increased valence ratings and amygdala responses to positive affective stimuli may reflect a positive processing bias contributing to elevated mood states characteristic for euphoric mania. |
| doi_str_mv | 10.1111/j.1399-5618.2008.00648.x |
| format | Article |
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Methods: We compared 10 patients with 10 matched healthy control subjects. We measured blood oxygen level‐dependent (BOLD) responses in the amygdala while subjects passively viewed photographs taken from the International Affective Picture System. After the fMRI session, subjects saw the pictures again and subjectively rated the emotional valence and intensity of each picture.
Results: Compared to healthy individuals, hypomanic or manic patients showed higher valence ratings in positive pictures and associated larger BOLD responses in the left amygdala during positive versus neutral picture viewing. This enhanced amygdala activation was correlated with Young Mania Rating Scale scores and with euphoric as opposed to irritable symptom presentation.
Conclusions: Increased valence ratings and amygdala responses to positive affective stimuli may reflect a positive processing bias contributing to elevated mood states characteristic for euphoric mania.</description><identifier>ISSN: 1398-5647</identifier><identifier>EISSN: 1399-5618</identifier><identifier>DOI: 10.1111/j.1399-5618.2008.00648.x</identifier><identifier>PMID: 19133968</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Affect - physiology ; amygdala ; Amygdala - blood supply ; Bipolar Disorder - pathology ; Bipolar Disorder - physiopathology ; Brain Mapping ; Case-Control Studies ; euphoria ; Female ; functional magnetic resonance imaging ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging - methods ; Male ; mania ; Middle Aged ; Oxygen - blood ; Photic Stimulation - methods ; Reaction Time - physiology ; Severity of Illness Index ; Visual Perception ; Young Adult ; Young Mania Rating Scale</subject><ispartof>Bipolar disorders, 2009-02, Vol.11 (1), p.70-75</ispartof><rights>2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5518-c9765ffa022c730318f777de41f0c67e9093233cd763f252e59e288a8797deed3</citedby><cites>FETCH-LOGICAL-c5518-c9765ffa022c730318f777de41f0c67e9093233cd763f252e59e288a8797deed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-5618.2008.00648.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-5618.2008.00648.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19133968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bermpohl, Felix</creatorcontrib><creatorcontrib>Dalanay, Umut</creatorcontrib><creatorcontrib>Kahnt, Thorsten</creatorcontrib><creatorcontrib>Sajonz, Bastian</creatorcontrib><creatorcontrib>Heimann, Hannah</creatorcontrib><creatorcontrib>Ricken, Roland</creatorcontrib><creatorcontrib>Stoy, Meline</creatorcontrib><creatorcontrib>Hägele, Claudia</creatorcontrib><creatorcontrib>Schlagenhauf, Florian</creatorcontrib><creatorcontrib>Adli, Mazda</creatorcontrib><creatorcontrib>Wrase, Jana</creatorcontrib><creatorcontrib>Ströhle, Andreas</creatorcontrib><creatorcontrib>Heinz, Andreas</creatorcontrib><creatorcontrib>Bauer, Michael</creatorcontrib><title>A preliminary study of increased amygdala activation to positive affective stimuli in mania</title><title>Bipolar disorders</title><addtitle>Bipolar Disord</addtitle><description>Objectives: The present study in hypomanic and manic patients explored how amygdala responses to affective stimuli depend on the valence of the stimuli presented.
Methods: We compared 10 patients with 10 matched healthy control subjects. We measured blood oxygen level‐dependent (BOLD) responses in the amygdala while subjects passively viewed photographs taken from the International Affective Picture System. After the fMRI session, subjects saw the pictures again and subjectively rated the emotional valence and intensity of each picture.
Results: Compared to healthy individuals, hypomanic or manic patients showed higher valence ratings in positive pictures and associated larger BOLD responses in the left amygdala during positive versus neutral picture viewing. This enhanced amygdala activation was correlated with Young Mania Rating Scale scores and with euphoric as opposed to irritable symptom presentation.
Conclusions: Increased valence ratings and amygdala responses to positive affective stimuli may reflect a positive processing bias contributing to elevated mood states characteristic for euphoric mania.</description><subject>Adult</subject><subject>Affect - physiology</subject><subject>amygdala</subject><subject>Amygdala - blood supply</subject><subject>Bipolar Disorder - pathology</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Brain Mapping</subject><subject>Case-Control Studies</subject><subject>euphoria</subject><subject>Female</subject><subject>functional magnetic resonance imaging</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>mania</subject><subject>Middle Aged</subject><subject>Oxygen - blood</subject><subject>Photic Stimulation - methods</subject><subject>Reaction Time - physiology</subject><subject>Severity of Illness Index</subject><subject>Visual Perception</subject><subject>Young Adult</subject><subject>Young Mania Rating Scale</subject><issn>1398-5647</issn><issn>1399-5618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUlPHDEUhK0oKGz5C8gnbt3xMt6kXAi7MhBFJOKQg2Xcz5GHXoZ2N5n59_EsgiP44rJc33tSFUKYkpLm82VWUm5MISTVJSNEl4TIiS4XH9Dey8fHtdZZT9Qu2k9pRgiVjIhPaJcayrmReg_9OcHzHurYxNb1S5yGsVriLuDY-h5cggq7Zvm3crXDzg_x2Q2xa_HQ4XmXYn4DdiGAX6s0xGasY2Zx49roDtFOcHWCz9v7AP2-OP91elVMf1xen55MCy8E1YU3SooQHGHMK0441UEpVcGEBuKlAkMMZ5z7SkkemGAgDDCtnVYmu6DiB-h4M3fed08jpME2MXmoa9dCNyYrpaaCcvqmkREuJlzrbNQbo--7lHoIdt7HJgdkKbGrBuzMroK2q6DtqgG7bsAuMnq03TE-NFC9gtvIs-HrxvAv1rB892D77ew6i4wXGzymARYvuOsfrVRcCXt_e2kvft5N2c39d8v4fzU2o-I</recordid><startdate>200902</startdate><enddate>200902</enddate><creator>Bermpohl, Felix</creator><creator>Dalanay, Umut</creator><creator>Kahnt, Thorsten</creator><creator>Sajonz, Bastian</creator><creator>Heimann, Hannah</creator><creator>Ricken, Roland</creator><creator>Stoy, Meline</creator><creator>Hägele, Claudia</creator><creator>Schlagenhauf, Florian</creator><creator>Adli, Mazda</creator><creator>Wrase, Jana</creator><creator>Ströhle, Andreas</creator><creator>Heinz, Andreas</creator><creator>Bauer, Michael</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200902</creationdate><title>A preliminary study of increased amygdala activation to positive affective stimuli in mania</title><author>Bermpohl, Felix ; Dalanay, Umut ; Kahnt, Thorsten ; Sajonz, Bastian ; Heimann, Hannah ; Ricken, Roland ; Stoy, Meline ; Hägele, Claudia ; Schlagenhauf, Florian ; Adli, Mazda ; Wrase, Jana ; Ströhle, Andreas ; Heinz, Andreas ; Bauer, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5518-c9765ffa022c730318f777de41f0c67e9093233cd763f252e59e288a8797deed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Affect - physiology</topic><topic>amygdala</topic><topic>Amygdala - blood supply</topic><topic>Bipolar Disorder - pathology</topic><topic>Bipolar Disorder - physiopathology</topic><topic>Brain Mapping</topic><topic>Case-Control Studies</topic><topic>euphoria</topic><topic>Female</topic><topic>functional magnetic resonance imaging</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>mania</topic><topic>Middle Aged</topic><topic>Oxygen - blood</topic><topic>Photic Stimulation - methods</topic><topic>Reaction Time - physiology</topic><topic>Severity of Illness Index</topic><topic>Visual Perception</topic><topic>Young Adult</topic><topic>Young Mania Rating Scale</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bermpohl, Felix</creatorcontrib><creatorcontrib>Dalanay, Umut</creatorcontrib><creatorcontrib>Kahnt, Thorsten</creatorcontrib><creatorcontrib>Sajonz, Bastian</creatorcontrib><creatorcontrib>Heimann, Hannah</creatorcontrib><creatorcontrib>Ricken, Roland</creatorcontrib><creatorcontrib>Stoy, Meline</creatorcontrib><creatorcontrib>Hägele, Claudia</creatorcontrib><creatorcontrib>Schlagenhauf, Florian</creatorcontrib><creatorcontrib>Adli, Mazda</creatorcontrib><creatorcontrib>Wrase, Jana</creatorcontrib><creatorcontrib>Ströhle, Andreas</creatorcontrib><creatorcontrib>Heinz, Andreas</creatorcontrib><creatorcontrib>Bauer, Michael</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bipolar disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bermpohl, Felix</au><au>Dalanay, Umut</au><au>Kahnt, Thorsten</au><au>Sajonz, Bastian</au><au>Heimann, Hannah</au><au>Ricken, Roland</au><au>Stoy, Meline</au><au>Hägele, Claudia</au><au>Schlagenhauf, Florian</au><au>Adli, Mazda</au><au>Wrase, Jana</au><au>Ströhle, Andreas</au><au>Heinz, Andreas</au><au>Bauer, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A preliminary study of increased amygdala activation to positive affective stimuli in mania</atitle><jtitle>Bipolar disorders</jtitle><addtitle>Bipolar Disord</addtitle><date>2009-02</date><risdate>2009</risdate><volume>11</volume><issue>1</issue><spage>70</spage><epage>75</epage><pages>70-75</pages><issn>1398-5647</issn><eissn>1399-5618</eissn><abstract>Objectives: The present study in hypomanic and manic patients explored how amygdala responses to affective stimuli depend on the valence of the stimuli presented.
Methods: We compared 10 patients with 10 matched healthy control subjects. We measured blood oxygen level‐dependent (BOLD) responses in the amygdala while subjects passively viewed photographs taken from the International Affective Picture System. After the fMRI session, subjects saw the pictures again and subjectively rated the emotional valence and intensity of each picture.
Results: Compared to healthy individuals, hypomanic or manic patients showed higher valence ratings in positive pictures and associated larger BOLD responses in the left amygdala during positive versus neutral picture viewing. This enhanced amygdala activation was correlated with Young Mania Rating Scale scores and with euphoric as opposed to irritable symptom presentation.
Conclusions: Increased valence ratings and amygdala responses to positive affective stimuli may reflect a positive processing bias contributing to elevated mood states characteristic for euphoric mania.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19133968</pmid><doi>10.1111/j.1399-5618.2008.00648.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Affect - physiology amygdala Amygdala - blood supply Bipolar Disorder - pathology Bipolar Disorder - physiopathology Brain Mapping Case-Control Studies euphoria Female functional magnetic resonance imaging Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging - methods Male mania Middle Aged Oxygen - blood Photic Stimulation - methods Reaction Time - physiology Severity of Illness Index Visual Perception Young Adult Young Mania Rating Scale |
| title | A preliminary study of increased amygdala activation to positive affective stimuli in mania |
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