Presence OF CXCR3-Positive Cells and IFN-γ–Producing Cells in Human Periapical Granulomas
In an attempt to understand further the balance between the types of helper T (Th) cells in human apical periodontitis, we examined the difference in the expression of the chemokine receptor and cytokine in samples obtained from human subjects by means of immunohistochemical methods. Chemokine recep...
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| Veröffentlicht in: | Journal of endodontics 2004-09, Vol.30 (9), p.634-637 |
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| container_title | Journal of endodontics |
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| creator | Kabashima, Hiroaki Yoneda, Masahiro Nakamuta, Hiroyoshi Nagata, Kengo Isobe, Ryoko Motooka, Noriko Maeda, Katsumasa |
| description | In an attempt to understand further the balance between the types of helper T (Th) cells in human apical periodontitis, we examined the difference in the expression of the chemokine receptor and cytokine in samples obtained from human subjects by means of immunohistochemical methods. Chemokine receptor CXCR3-positive cells and IFN-γ–producing cells were found to be present in human periapical granulomas, whereas chemokine receptor CCR3-positive cells and IL-4–producing cells could not be detected. By contrast, no factor expression was observed in a clinically healthy periodontal ligament serving as a negative control. Our findings suggest that Th1 cells may play an important role in the pathological process of local inflammation such as apical periodontitis. |
| doi_str_mv | 10.1097/01.DON.0000125878.34119.3E |
| format | Article |
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Chemokine receptor CXCR3-positive cells and IFN-γ–producing cells were found to be present in human periapical granulomas, whereas chemokine receptor CCR3-positive cells and IL-4–producing cells could not be detected. By contrast, no factor expression was observed in a clinically healthy periodontal ligament serving as a negative control. 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Chemokine receptor CXCR3-positive cells and IFN-γ–producing cells were found to be present in human periapical granulomas, whereas chemokine receptor CCR3-positive cells and IL-4–producing cells could not be detected. By contrast, no factor expression was observed in a clinically healthy periodontal ligament serving as a negative control. Our findings suggest that Th1 cells may play an important role in the pathological process of local inflammation such as apical periodontitis.</description><subject>Adult</subject><subject>Dentistry</subject><subject>Humans</subject><subject>Interferon-Stimulated Gene Factor 3</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Periapical Granuloma - immunology</subject><subject>Periapical Granuloma - pathology</subject><subject>Receptors, Chemokine - analysis</subject><subject>Receptors, CXCR3</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - immunology</subject><subject>Transcription Factors - analysis</subject><issn>0099-2399</issn><issn>1878-3554</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1KxDAQgIMouv68ghQP3lqTTtM23qT7oyBuEQUPQkiTVCL9WZPtgjffwUfxPXwIn8ToLnh1LmGYbzIzH0InBEcEs-wMk2g8v4mwDxLTPMsjSAhhEUy20Ij4PARKk200wpixMAbG9tC-c88ezwCyXbRHKMSMpukIPZZWO91JHcynQfFQ3EJY9s4szUoHhW4aF4hOBVfTm_Dz4-vtvbS9GqTpnjZF0wWXQyu6oNTWiIWRoglmVnRD07fCHaKdWjROH23eA3Q_ndwVl-H1fHZVXFyHMgFYhnWFKyFJRmslIVaEqcTvpnSeV4SAUBpnNSRMMUXrOBG-Glc1jiugomI5MDhAp-t_F7Z_GbRb8tY46RcUne4Hx9M0JxSnsQfP16C0vXNW13xhTSvsKyeY_7jlmHDvlv-55b9uOUx88_FmylC1Wv21bmR6YLwGtL91ZbTlTpoft8pYLZdc9eY_c74B1KaL7A</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Kabashima, Hiroaki</creator><creator>Yoneda, Masahiro</creator><creator>Nakamuta, Hiroyoshi</creator><creator>Nagata, Kengo</creator><creator>Isobe, Ryoko</creator><creator>Motooka, Noriko</creator><creator>Maeda, Katsumasa</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Presence OF CXCR3-Positive Cells and IFN-γ–Producing Cells in Human Periapical Granulomas</title><author>Kabashima, Hiroaki ; Yoneda, Masahiro ; Nakamuta, Hiroyoshi ; Nagata, Kengo ; Isobe, Ryoko ; Motooka, Noriko ; Maeda, Katsumasa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-fb0bac175fdc32d19d4566de88b113ade07f349d9d5f24ad452bf02b35ab98393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Dentistry</topic><topic>Humans</topic><topic>Interferon-Stimulated Gene Factor 3</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Periapical Granuloma - immunology</topic><topic>Periapical Granuloma - pathology</topic><topic>Receptors, Chemokine - analysis</topic><topic>Receptors, CXCR3</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - immunology</topic><topic>Transcription Factors - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kabashima, Hiroaki</creatorcontrib><creatorcontrib>Yoneda, Masahiro</creatorcontrib><creatorcontrib>Nakamuta, Hiroyoshi</creatorcontrib><creatorcontrib>Nagata, Kengo</creatorcontrib><creatorcontrib>Isobe, Ryoko</creatorcontrib><creatorcontrib>Motooka, Noriko</creatorcontrib><creatorcontrib>Maeda, Katsumasa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kabashima, Hiroaki</au><au>Yoneda, Masahiro</au><au>Nakamuta, Hiroyoshi</au><au>Nagata, Kengo</au><au>Isobe, Ryoko</au><au>Motooka, Noriko</au><au>Maeda, Katsumasa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presence OF CXCR3-Positive Cells and IFN-γ–Producing Cells in Human Periapical Granulomas</atitle><jtitle>Journal of endodontics</jtitle><addtitle>J Endod</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>30</volume><issue>9</issue><spage>634</spage><epage>637</epage><pages>634-637</pages><issn>0099-2399</issn><eissn>1878-3554</eissn><abstract>In an attempt to understand further the balance between the types of helper T (Th) cells in human apical periodontitis, we examined the difference in the expression of the chemokine receptor and cytokine in samples obtained from human subjects by means of immunohistochemical methods. 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| ispartof | Journal of endodontics, 2004-09, Vol.30 (9), p.634-637 |
| issn | 0099-2399 1878-3554 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Dentistry Humans Interferon-Stimulated Gene Factor 3 Male Middle Aged Periapical Granuloma - immunology Periapical Granuloma - pathology Receptors, Chemokine - analysis Receptors, CXCR3 Th1 Cells - immunology Th2 Cells - immunology Transcription Factors - analysis |
| title | Presence OF CXCR3-Positive Cells and IFN-γ–Producing Cells in Human Periapical Granulomas |
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