Intramembrane Proteolysis: Theme and Variations

Proteases that reside in cellular membranes apparently wield water to hydrolyze the peptide bonds of substrates despite their water-excluding environment. Although these intramembrane proteases bear little or no sequence resemblance to classical water-soluble proteases, they have ostensibly converge...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2004-08, Vol.305 (5687), p.1119-1123
Hauptverfasser:	Wolfe, Michael S., Kopan, Raphael
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites Amyloid Precursor Protein Secretases Analytical, structural and metabolic biochemistry Animals Aspartic Acid Endopeptidases - chemistry Aspartic Acid Endopeptidases - metabolism Binding Sites Biochemistry Biological and medical sciences Catalysis Cell Membrane - enzymology Cell membranes Cholesterols Cytosol Drosophila Proteins - chemistry Drosophila Proteins - metabolism Endopeptidases - chemistry Endopeptidases - metabolism Environment Enzyme substrates Enzymes Enzymes and enzyme inhibitors Family (Sociological Unit) Fundamental and applied biological sciences. Psychology Humans Hydrolases Hydrolysis Hydrophobic and Hydrophilic Interactions Membrane proteins Membrane Proteins - chemistry Membrane Proteins - metabolism Metalloendopeptidases - chemistry Metalloendopeptidases - metabolism Musical Composition Presenilins Properties Proteases Proteolysis Review Solubility Transcription factors Water
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