BNIP3 Expression Is Linked with Hypoxia-Regulated Protein Expression and with Poor Prognosis in Non–Small Cell Lung Cancer

BNIP3 is a proapoptotic protein regulated by hypoxia-inducible factor 1. We analyzed BNIP3 expression in 105 tumor samples from early operable, non-small lung cancer and the relationship of expression to hypoxia-inducible factor 1α, other hypoxia-regulated pathways, and prognosis. There was strong c...

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Veröffentlicht in:	Clinical cancer research 2004-08, Vol.10 (16), p.5566-5571
Hauptverfasser:	GIATROMANOLAKI, Alexandra, KOUKOURAKIS, Michael I, SOWTER, Heidi M, SIVRIDIS, Efthimios, GIBSON, Spencer, GATTER, Kevin C, HARRIS, Adrian L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - pathology Antineoplastic agents Apoptosis Biological and medical sciences Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Cell Hypoxia Humans Hypoxia-Inducible Factor 1, alpha Subunit Immunohistochemistry Lung Neoplasms - mortality Lung Neoplasms - pathology Medical sciences Membrane Proteins - genetics Neoplasm Staging Neovascularization, Pathologic Pharmacology. Drug treatments Prognosis Proto-Oncogene Proteins - genetics RNA, Messenger - genetics Transcription Factors - genetics Tumors
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