Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo
Summary Background Terahertz radiation lies between the infrared and microwave regions of the electromagnetic spectrum and can be used to excite large amplitude vibrational modes of molecules and probe the weak interactions between them. Terahertz pulsed imaging (TPI) is a noninvasive imaging techn...
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| Veröffentlicht in: | British journal of dermatology (1951) 2004-08, Vol.151 (2), p.424-432 |
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| container_title | British journal of dermatology (1951) |
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| creator | Wallace, V.P. Fitzgerald, A.J. Shankar, S. Flanagan, N. Pye, R. Cluff, J. Arnone, D.D. |
| description | Summary
Background Terahertz radiation lies between the infrared and microwave regions of the electromagnetic spectrum and can be used to excite large amplitude vibrational modes of molecules and probe the weak interactions between them. Terahertz pulsed imaging (TPI) is a noninvasive imaging technique that utilises this radiaton.
Objectives To determine whether TPI could differentiate between basal cell carcinoma (BCC) and normal tissue and to test whether it can help facilitate delineation of tumour margins prior to surgery.
Methods A portable TPI system was used in the clinic to image 18 BCCs ex vivo and five in vivo.
Results The diseased tissue showed a change in terahertz properties compared with normal tissue, manifested through a broadening of the reflected terahertz pulse. Regions of disease identified in the terahertz image correlated well with histology.
Conclusions This study has confirmed the potential of TPI to identify the extent of BCC in vivo and to delineate tumour margins. Further clinical study of TPI as a surgical tool is now required. |
| doi_str_mv | 10.1111/j.1365-2133.2004.06129.x |
| format | Article |
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Background Terahertz radiation lies between the infrared and microwave regions of the electromagnetic spectrum and can be used to excite large amplitude vibrational modes of molecules and probe the weak interactions between them. Terahertz pulsed imaging (TPI) is a noninvasive imaging technique that utilises this radiaton.
Objectives To determine whether TPI could differentiate between basal cell carcinoma (BCC) and normal tissue and to test whether it can help facilitate delineation of tumour margins prior to surgery.
Methods A portable TPI system was used in the clinic to image 18 BCCs ex vivo and five in vivo.
Results The diseased tissue showed a change in terahertz properties compared with normal tissue, manifested through a broadening of the reflected terahertz pulse. Regions of disease identified in the terahertz image correlated well with histology.
Conclusions This study has confirmed the potential of TPI to identify the extent of BCC in vivo and to delineate tumour margins. Further clinical study of TPI as a surgical tool is now required.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.2004.06129.x</identifier><identifier>PMID: 15327550</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Aged ; Aged, 80 and over ; basal cell carcinoma ; Biological and medical sciences ; Carcinoma, Basal Cell - pathology ; Dermatology ; diagnosis ; Diagnostic Imaging - instrumentation ; Diagnostic Imaging - methods ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Mohs' micrographic surgery ; Preoperative Care - methods ; Skin - pathology ; Skin Neoplasms - pathology ; Skin plastic surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; terahertz pulsed imaging ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>British journal of dermatology (1951), 2004-08, Vol.151 (2), p.424-432</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Aug 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5269-ff3d0d7e3cf0ca63c805a7630c3658d4a250fea1b4501c8192a8281453518f3d3</citedby><cites>FETCH-LOGICAL-c5269-ff3d0d7e3cf0ca63c805a7630c3658d4a250fea1b4501c8192a8281453518f3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.2004.06129.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.2004.06129.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16059866$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15327550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wallace, V.P.</creatorcontrib><creatorcontrib>Fitzgerald, A.J.</creatorcontrib><creatorcontrib>Shankar, S.</creatorcontrib><creatorcontrib>Flanagan, N.</creatorcontrib><creatorcontrib>Pye, R.</creatorcontrib><creatorcontrib>Cluff, J.</creatorcontrib><creatorcontrib>Arnone, D.D.</creatorcontrib><title>Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background Terahertz radiation lies between the infrared and microwave regions of the electromagnetic spectrum and can be used to excite large amplitude vibrational modes of molecules and probe the weak interactions between them. Terahertz pulsed imaging (TPI) is a noninvasive imaging technique that utilises this radiaton.
Objectives To determine whether TPI could differentiate between basal cell carcinoma (BCC) and normal tissue and to test whether it can help facilitate delineation of tumour margins prior to surgery.
Methods A portable TPI system was used in the clinic to image 18 BCCs ex vivo and five in vivo.
Results The diseased tissue showed a change in terahertz properties compared with normal tissue, manifested through a broadening of the reflected terahertz pulse. Regions of disease identified in the terahertz image correlated well with histology.
Conclusions This study has confirmed the potential of TPI to identify the extent of BCC in vivo and to delineate tumour margins. Further clinical study of TPI as a surgical tool is now required.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>basal cell carcinoma</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Basal Cell - pathology</subject><subject>Dermatology</subject><subject>diagnosis</subject><subject>Diagnostic Imaging - instrumentation</subject><subject>Diagnostic Imaging - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mohs' micrographic surgery</subject><subject>Preoperative Care - methods</subject><subject>Skin - pathology</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin plastic surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>terahertz pulsed imaging</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1O3DAURi3UCqaUV6isSu0u6bUd_2TRRWFaWgQUJFCX1h3HoZlmkqk9oQNPj8OMQOoKL2xLPufq80cIZZCztD7NcyaUzDgTIucARQ6K8TJf75DJ08MrMgEAnUGpxB55E-McgAmQsEv2mBRcSwkTMr3yAX_7sLqny6GNvqLNAm-a7ob2NZ1hxJY636YNg2u6foHUr-ltc9tT7BLbPd7fktc1Jvlge-6T629fr46-Z6c_j38cfTnNnOSqzOpaVFBpL1wNDpVwBiRqJcClzKYqkEuoPbJZIYE5w0qOhhtWSCGZSa7YJx83c5eh_zv4uLKLJo7xsPP9EK1SJn2flwl8_x8474fQpWw21QWy1KATZDaQC32Mwdd2GdLnw51lYMea7dyObdqxzdEr7GPNdp3Ud9v5w2zhq2dx22sCPmwBjA7bOmDnmvjMqZTBKJW4zxvuX9P6uxcHsIcn0_GW_GzjN3Hl108-hj9WaaGl_XV-bM90oeTFJdipeADS2KSi</recordid><startdate>200408</startdate><enddate>200408</enddate><creator>Wallace, V.P.</creator><creator>Fitzgerald, A.J.</creator><creator>Shankar, S.</creator><creator>Flanagan, N.</creator><creator>Pye, R.</creator><creator>Cluff, J.</creator><creator>Arnone, D.D.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200408</creationdate><title>Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo</title><author>Wallace, V.P. ; Fitzgerald, A.J. ; Shankar, S. ; Flanagan, N. ; Pye, R. ; Cluff, J. ; Arnone, D.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5269-ff3d0d7e3cf0ca63c805a7630c3658d4a250fea1b4501c8192a8281453518f3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>basal cell carcinoma</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Basal Cell - pathology</topic><topic>Dermatology</topic><topic>diagnosis</topic><topic>Diagnostic Imaging - instrumentation</topic><topic>Diagnostic Imaging - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mohs' micrographic surgery</topic><topic>Preoperative Care - methods</topic><topic>Skin - pathology</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin plastic surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>terahertz pulsed imaging</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wallace, V.P.</creatorcontrib><creatorcontrib>Fitzgerald, A.J.</creatorcontrib><creatorcontrib>Shankar, S.</creatorcontrib><creatorcontrib>Flanagan, N.</creatorcontrib><creatorcontrib>Pye, R.</creatorcontrib><creatorcontrib>Cluff, J.</creatorcontrib><creatorcontrib>Arnone, D.D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wallace, V.P.</au><au>Fitzgerald, A.J.</au><au>Shankar, S.</au><au>Flanagan, N.</au><au>Pye, R.</au><au>Cluff, J.</au><au>Arnone, D.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2004-08</date><risdate>2004</risdate><volume>151</volume><issue>2</issue><spage>424</spage><epage>432</epage><pages>424-432</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary
Background Terahertz radiation lies between the infrared and microwave regions of the electromagnetic spectrum and can be used to excite large amplitude vibrational modes of molecules and probe the weak interactions between them. Terahertz pulsed imaging (TPI) is a noninvasive imaging technique that utilises this radiaton.
Objectives To determine whether TPI could differentiate between basal cell carcinoma (BCC) and normal tissue and to test whether it can help facilitate delineation of tumour margins prior to surgery.
Methods A portable TPI system was used in the clinic to image 18 BCCs ex vivo and five in vivo.
Results The diseased tissue showed a change in terahertz properties compared with normal tissue, manifested through a broadening of the reflected terahertz pulse. Regions of disease identified in the terahertz image correlated well with histology.
Conclusions This study has confirmed the potential of TPI to identify the extent of BCC in vivo and to delineate tumour margins. Further clinical study of TPI as a surgical tool is now required.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15327550</pmid><doi>10.1111/j.1365-2133.2004.06129.x</doi><tpages>9</tpages></addata></record> |
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| ispartof | British journal of dermatology (1951), 2004-08, Vol.151 (2), p.424-432 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Wiley Online Library All Journals |
| subjects | Aged Aged, 80 and over basal cell carcinoma Biological and medical sciences Carcinoma, Basal Cell - pathology Dermatology diagnosis Diagnostic Imaging - instrumentation Diagnostic Imaging - methods Female Humans Male Medical sciences Middle Aged Mohs' micrographic surgery Preoperative Care - methods Skin - pathology Skin Neoplasms - pathology Skin plastic surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases terahertz pulsed imaging Tumors of the skin and soft tissue. Premalignant lesions |
| title | Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo |
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