(−)-Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of beta-amyloid generation and memory deficiency

Abstract Neuroinflammation has been known to play a role in the pathogenesis of AD. Our previous study showed that lipopolysaccharide (LPS) induced memory impairment through the accumulation of Aβ via the increase of β- and γ-secretase. In this study, we investigated the possible preventive effect o...

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Veröffentlicht in:	Brain research 2009-01, Vol.1250, p.164-174
Hauptverfasser:	Lee, Young Kyoung, Yuk, Dong Yeon, Lee, Jae Woong, Lee, Sun Young, Ha, Tae Youl, Oh, Ki Wan, Yun, Yeo Pyo, Hong, Jin Tae
Format:	Artikel
Sprache:	eng
Schlagworte:	(−)-Epigallocatechin-3-gallate (EGCG) Adult and adolescent clinical studies Alzheimer's disease (AD) Amyloid beta-Peptides - metabolism Amyloid Precursor Protein Secretases - metabolism Animals Apoptosis - drug effects Avoidance Learning - drug effects Biological and medical sciences Brain - drug effects Brain - metabolism Catechin - administration & dosage Catechin - analogs & derivatives Catechin - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cyclooxygenase 2 - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Glial Fibrillary Acidic Protein Hippocampus - drug effects Hippocampus - metabolism Lipopolysaccharide (LPS) Lipopolysaccharides Male Maze Learning - drug effects Medical sciences Memory - drug effects Memory Disorders - physiopathology Memory Disorders - prevention & control Mice Nerve Tissue Proteins - metabolism Neuroinflammation Neurology Neurons - drug effects Neurons - metabolism Nitric Oxide Synthase Type II - metabolism Organic mental disorders. Neuropsychology Peptide Fragments - metabolism Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry
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