Small cell carcinoma of the urinary bladder: A clinicopathologic analysis of 64 patients
Small cell carcinoma of the urinary bladder is an uncommon tumor that has been described in case reports or small series. Herein, the authors report a series of 64 patients with small cell carcinoma of the urinary bladder. Histologic slides and medical records from 64 patients with small cell carcin...
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Veröffentlicht in: | Cancer 2004-09, Vol.101 (5), p.957-962 |
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creator | LIANG CHENG PAN, Chong-Xian KOCH, Michael O EBLE, John N YANG, Ximing J LOPEZ-BELTRAN, Antonio MACLENNAN, Gregory T HAIQUN LIN KUZEL, Timothy M PAPAVERO, Veronica TRETIAKOVA, Maria NIGRO, Kelly |
description | Small cell carcinoma of the urinary bladder is an uncommon tumor that has been described in case reports or small series. Herein, the authors report a series of 64 patients with small cell carcinoma of the urinary bladder.
Histologic slides and medical records from 64 patients with small cell carcinoma of the urinary bladder were reviewed for morphologic, demographic, and clinical data. All patients fulfilled the criteria established for small cell carcinoma according to the World Health Organization classification system. The 2002 tumor, lymph node, and metastasis (TNM) system was used for pathologic staging. The correlations of various clinicopathologic characteristics with survival were analyzed.
Patients ranged in age from 36 years to 85 years (mean age, 66 years). The male-to-female ratio was 3.3:1.0. Among patients with clinical information available, 65% had a history of cigarette smoking, and 88% presented with hematuria. All but one patient had muscle-invasive disease at presentation. Thirty-eight patients (59%) underwent cystectomy. Sixty-six percent of patients had lymph node metastasis at the time of cystectomy. Twenty patients (32%) had pure small cell carcinoma, and 44 patients (68%) had small cell carcinoma with other histologic types (35 patients had urothelial carcinoma, 4 patients had adenocarcinoma, 2 patients had sarcomatoid urothelial carcinoma, and 3 patients had both adenocarcinoma and urothelial carcinoma). With a mean follow-up of 21 months, 68% of patients died of bladder carcinoma. None of the clinicopathologic parameters studied (age, gender, presenting symptoms, smoking history, the presence of a nonsmall cell carcinoma component, chemotherapy, or radiation therapy) were associated with survival. No significant survival difference was found between patients who did and did not undergo cystectomy (P = 0.65). Patients who had organ-confined disease had marginally better survival compared with patients who had nonorgan-confined disease (P = 0.06). The overall, 1-year, 18-month, 3-year, and 5-year disease-specific survival rates were 56%, 41%, 23%, and 16%, respectively.
The prognosis for patients with small cell carcinoma of the urinary bladder remains poor, even though the overall survival for patients with bladder carcinoma has improved significantly over the last decade. |
doi_str_mv | 10.1002/cncr.20456 |
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Histologic slides and medical records from 64 patients with small cell carcinoma of the urinary bladder were reviewed for morphologic, demographic, and clinical data. All patients fulfilled the criteria established for small cell carcinoma according to the World Health Organization classification system. The 2002 tumor, lymph node, and metastasis (TNM) system was used for pathologic staging. The correlations of various clinicopathologic characteristics with survival were analyzed.
Patients ranged in age from 36 years to 85 years (mean age, 66 years). The male-to-female ratio was 3.3:1.0. Among patients with clinical information available, 65% had a history of cigarette smoking, and 88% presented with hematuria. All but one patient had muscle-invasive disease at presentation. Thirty-eight patients (59%) underwent cystectomy. Sixty-six percent of patients had lymph node metastasis at the time of cystectomy. Twenty patients (32%) had pure small cell carcinoma, and 44 patients (68%) had small cell carcinoma with other histologic types (35 patients had urothelial carcinoma, 4 patients had adenocarcinoma, 2 patients had sarcomatoid urothelial carcinoma, and 3 patients had both adenocarcinoma and urothelial carcinoma). With a mean follow-up of 21 months, 68% of patients died of bladder carcinoma. None of the clinicopathologic parameters studied (age, gender, presenting symptoms, smoking history, the presence of a nonsmall cell carcinoma component, chemotherapy, or radiation therapy) were associated with survival. No significant survival difference was found between patients who did and did not undergo cystectomy (P = 0.65). Patients who had organ-confined disease had marginally better survival compared with patients who had nonorgan-confined disease (P = 0.06). The overall, 1-year, 18-month, 3-year, and 5-year disease-specific survival rates were 56%, 41%, 23%, and 16%, respectively.
The prognosis for patients with small cell carcinoma of the urinary bladder remains poor, even though the overall survival for patients with bladder carcinoma has improved significantly over the last decade.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.20456</identifier><identifier>PMID: 15329903</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York, NY: Wiley-Liss</publisher><subject>Adenocarcinoma - pathology ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Small Cell - pathology ; Cystectomy ; Female ; Humans ; Lymphatic Metastasis - pathology ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Prognosis ; Survival Rate ; Tumors ; Urinary Bladder Neoplasms - pathology ; Urothelium - pathology</subject><ispartof>Cancer, 2004-09, Vol.101 (5), p.957-962</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 American Cancer Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c272t-96eb3b15337b8855f9ae19de333da6752b50a3eaa763acd2a62d4d6f8d0a0ccd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16039934$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15329903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LIANG CHENG</creatorcontrib><creatorcontrib>PAN, Chong-Xian</creatorcontrib><creatorcontrib>KOCH, Michael O</creatorcontrib><creatorcontrib>EBLE, John N</creatorcontrib><creatorcontrib>YANG, Ximing J</creatorcontrib><creatorcontrib>LOPEZ-BELTRAN, Antonio</creatorcontrib><creatorcontrib>MACLENNAN, Gregory T</creatorcontrib><creatorcontrib>HAIQUN LIN</creatorcontrib><creatorcontrib>KUZEL, Timothy M</creatorcontrib><creatorcontrib>PAPAVERO, Veronica</creatorcontrib><creatorcontrib>TRETIAKOVA, Maria</creatorcontrib><creatorcontrib>NIGRO, Kelly</creatorcontrib><title>Small cell carcinoma of the urinary bladder: A clinicopathologic analysis of 64 patients</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Small cell carcinoma of the urinary bladder is an uncommon tumor that has been described in case reports or small series. Herein, the authors report a series of 64 patients with small cell carcinoma of the urinary bladder.
Histologic slides and medical records from 64 patients with small cell carcinoma of the urinary bladder were reviewed for morphologic, demographic, and clinical data. All patients fulfilled the criteria established for small cell carcinoma according to the World Health Organization classification system. The 2002 tumor, lymph node, and metastasis (TNM) system was used for pathologic staging. The correlations of various clinicopathologic characteristics with survival were analyzed.
Patients ranged in age from 36 years to 85 years (mean age, 66 years). The male-to-female ratio was 3.3:1.0. Among patients with clinical information available, 65% had a history of cigarette smoking, and 88% presented with hematuria. All but one patient had muscle-invasive disease at presentation. Thirty-eight patients (59%) underwent cystectomy. Sixty-six percent of patients had lymph node metastasis at the time of cystectomy. Twenty patients (32%) had pure small cell carcinoma, and 44 patients (68%) had small cell carcinoma with other histologic types (35 patients had urothelial carcinoma, 4 patients had adenocarcinoma, 2 patients had sarcomatoid urothelial carcinoma, and 3 patients had both adenocarcinoma and urothelial carcinoma). With a mean follow-up of 21 months, 68% of patients died of bladder carcinoma. None of the clinicopathologic parameters studied (age, gender, presenting symptoms, smoking history, the presence of a nonsmall cell carcinoma component, chemotherapy, or radiation therapy) were associated with survival. No significant survival difference was found between patients who did and did not undergo cystectomy (P = 0.65). Patients who had organ-confined disease had marginally better survival compared with patients who had nonorgan-confined disease (P = 0.06). The overall, 1-year, 18-month, 3-year, and 5-year disease-specific survival rates were 56%, 41%, 23%, and 16%, respectively.
The prognosis for patients with small cell carcinoma of the urinary bladder remains poor, even though the overall survival for patients with bladder carcinoma has improved significantly over the last decade.</description><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Small Cell - pathology</subject><subject>Cystectomy</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Survival Rate</subject><subject>Tumors</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urothelium - pathology</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtOwzAQRS0EoqWw4QOQN7BASvEjdmJ2VcVLqsQCkLqLJrZDjZyk2Mmif09CK3Uzo9GcuZp7EbqmZE4JYQ-60WHOSCrkCZpSorKE0JSdoikhJE9EytcTdBHjzzBmTPBzNKGCM6UIn6L1Rw3eY23HAkG7pq0BtxXuNhb3wTUQdrj0YIwNj3iBtXeN0-0Wuk3r22-nMTTgd9HF8UimeNg423TxEp1V4KO9OvQZ-np--ly-Jqv3l7flYpVolrEuUdKWvBz-4VmZ50JUCixVxnLODchMsFIQ4BYgkxy0YSCZSY2sckOAaG34DN3tdbeh_e1t7IraxdEONLbtYyFlTpkSdADv96AObYzBVsU2uHqwV1BSjDkWY47Ff44DfHNQ7cvamiN6CG4Abg8ARA2-CtBoF4-cJFwpnvI_Yg57mg</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>LIANG CHENG</creator><creator>PAN, Chong-Xian</creator><creator>KOCH, Michael O</creator><creator>EBLE, John N</creator><creator>YANG, Ximing J</creator><creator>LOPEZ-BELTRAN, Antonio</creator><creator>MACLENNAN, Gregory T</creator><creator>HAIQUN LIN</creator><creator>KUZEL, Timothy M</creator><creator>PAPAVERO, Veronica</creator><creator>TRETIAKOVA, Maria</creator><creator>NIGRO, Kelly</creator><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Small cell carcinoma of the urinary bladder: A clinicopathologic analysis of 64 patients</title><author>LIANG CHENG ; PAN, Chong-Xian ; KOCH, Michael O ; EBLE, John N ; YANG, Ximing J ; LOPEZ-BELTRAN, Antonio ; MACLENNAN, Gregory T ; HAIQUN LIN ; KUZEL, Timothy M ; PAPAVERO, Veronica ; TRETIAKOVA, Maria ; NIGRO, Kelly</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-96eb3b15337b8855f9ae19de333da6752b50a3eaa763acd2a62d4d6f8d0a0ccd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Small Cell - pathology</topic><topic>Cystectomy</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Survival Rate</topic><topic>Tumors</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urothelium - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LIANG CHENG</creatorcontrib><creatorcontrib>PAN, Chong-Xian</creatorcontrib><creatorcontrib>KOCH, Michael O</creatorcontrib><creatorcontrib>EBLE, John N</creatorcontrib><creatorcontrib>YANG, Ximing J</creatorcontrib><creatorcontrib>LOPEZ-BELTRAN, Antonio</creatorcontrib><creatorcontrib>MACLENNAN, Gregory T</creatorcontrib><creatorcontrib>HAIQUN LIN</creatorcontrib><creatorcontrib>KUZEL, Timothy M</creatorcontrib><creatorcontrib>PAPAVERO, Veronica</creatorcontrib><creatorcontrib>TRETIAKOVA, Maria</creatorcontrib><creatorcontrib>NIGRO, Kelly</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LIANG CHENG</au><au>PAN, Chong-Xian</au><au>KOCH, Michael O</au><au>EBLE, John N</au><au>YANG, Ximing J</au><au>LOPEZ-BELTRAN, Antonio</au><au>MACLENNAN, Gregory T</au><au>HAIQUN LIN</au><au>KUZEL, Timothy M</au><au>PAPAVERO, Veronica</au><au>TRETIAKOVA, Maria</au><au>NIGRO, Kelly</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small cell carcinoma of the urinary bladder: A clinicopathologic analysis of 64 patients</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>101</volume><issue>5</issue><spage>957</spage><epage>962</epage><pages>957-962</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>Small cell carcinoma of the urinary bladder is an uncommon tumor that has been described in case reports or small series. Herein, the authors report a series of 64 patients with small cell carcinoma of the urinary bladder.
Histologic slides and medical records from 64 patients with small cell carcinoma of the urinary bladder were reviewed for morphologic, demographic, and clinical data. All patients fulfilled the criteria established for small cell carcinoma according to the World Health Organization classification system. The 2002 tumor, lymph node, and metastasis (TNM) system was used for pathologic staging. The correlations of various clinicopathologic characteristics with survival were analyzed.
Patients ranged in age from 36 years to 85 years (mean age, 66 years). The male-to-female ratio was 3.3:1.0. Among patients with clinical information available, 65% had a history of cigarette smoking, and 88% presented with hematuria. All but one patient had muscle-invasive disease at presentation. Thirty-eight patients (59%) underwent cystectomy. Sixty-six percent of patients had lymph node metastasis at the time of cystectomy. Twenty patients (32%) had pure small cell carcinoma, and 44 patients (68%) had small cell carcinoma with other histologic types (35 patients had urothelial carcinoma, 4 patients had adenocarcinoma, 2 patients had sarcomatoid urothelial carcinoma, and 3 patients had both adenocarcinoma and urothelial carcinoma). With a mean follow-up of 21 months, 68% of patients died of bladder carcinoma. None of the clinicopathologic parameters studied (age, gender, presenting symptoms, smoking history, the presence of a nonsmall cell carcinoma component, chemotherapy, or radiation therapy) were associated with survival. No significant survival difference was found between patients who did and did not undergo cystectomy (P = 0.65). Patients who had organ-confined disease had marginally better survival compared with patients who had nonorgan-confined disease (P = 0.06). The overall, 1-year, 18-month, 3-year, and 5-year disease-specific survival rates were 56%, 41%, 23%, and 16%, respectively.
The prognosis for patients with small cell carcinoma of the urinary bladder remains poor, even though the overall survival for patients with bladder carcinoma has improved significantly over the last decade.</abstract><cop>New York, NY</cop><pub>Wiley-Liss</pub><pmid>15329903</pmid><doi>10.1002/cncr.20456</doi><tpages>6</tpages></addata></record> |
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subjects | Adenocarcinoma - pathology Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Small Cell - pathology Cystectomy Female Humans Lymphatic Metastasis - pathology Male Medical sciences Middle Aged Neoplasm Staging Prognosis Survival Rate Tumors Urinary Bladder Neoplasms - pathology Urothelium - pathology |
title | Small cell carcinoma of the urinary bladder: A clinicopathologic analysis of 64 patients |
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