The interactive effect of the cholinergic system and acute ovarian suppression on the brain: An fMRI study
Recent evidence suggests that loss of ovarian function following ovariectomy is a risk factor for Alzheimer's disease (AD); however, the biological basis of this risk remains poorly understood. We carried out an fMRI study into the interaction between loss of ovarian function (after Gonadotropi...
Gespeichert in:
| Veröffentlicht in: | Hormones and behavior 2009, Vol.55 (1), p.41-49 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 49 |
|---|---|
| container_issue | 1 |
| container_start_page | 41 |
| container_title | Hormones and behavior |
| container_volume | 55 |
| creator | Craig, M.C. Fletcher, P.C. Daly, E.M. Rymer, J. Brammer, M. Giampietro, V. Stahl, D. Maki, P.M. Murphy, Declan G.M. |
| description | Recent evidence suggests that loss of ovarian function following ovariectomy is a risk factor for Alzheimer's disease (AD); however, the biological basis of this risk remains poorly understood. We carried out an
fMRI study into the interaction between loss of ovarian function (after Gonadotropin Hormone Releasing Hormone agonist (GnRHa) treatment) and scopolamine (a cholinergic antagonist used to model the memory decline associated with aging and AD). Behaviorally, cholinergic depletion produced a deficit in verbal recognition performance in both GnRHa-treated women and wait list controls, but only GnRHa-treated women made more false positive errors with cholinergic depletion. Similarly, cholinergic depletion produced a decrease in activation in the left inferior frontal gyrus (LIFG; Brodmann area 45) – a brain region implicated in retrieving word meaning – in both groups, and activation in this area was further reduced following GnRHa treatment. These findings suggest biological mechanisms through which ovarian hormone suppression may interact with the cholinergic system and the LIFG. Furthermore, this interaction may provide a useful model to help explain reports of increased risk for cognitive decline and AD in women following ovariectomy. |
| doi_str_mv | 10.1016/j.yhbeh.2008.08.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66812041</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0018506X0800247X</els_id><sourcerecordid>66812041</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-4808343fa4ce1d9d32101a78f2a47a88fc4936dab34aac29e181bc3e17d37a283</originalsourceid><addsrcrecordid>eNqFkW-L1DAQxoMo3nr6CQQJgr7rXtKmaSrci-Pwz8EdgpzguzBNJ25KN12TdGG__aXuouALDx4YhvnNMDMPIa85W3PG5cWwPmw63KxLxtR6EVNPyIqzti6kks1TsmKMq6Jm8scZeRHjkFNeC_GcnHGlWCuYXJHhfoPU-YQBTHJ7pGgtmkQnS1OumM00Oo_hpzM0HmLCLQXfUzBzQjrtITjwNM67XcAY3eRp1tLXBXD-A73y1N59u6Exzf3hJXlmYYz46hTPyfdPH--vvxS3Xz_fXF_dFkaIOhVCMVWJyoIwyPu2r8p8LTTKliAaUMoa0Vayh64SAKZskSvemQp501cNlKo6J--Pc3dh-jVjTHrrosFxBI_THLWUipdM8EfBkpVNXTYL-PYfcJjm4PMRmrei5UzWMkPVETJhijGg1bvgthAOmjO9GKYH_dswvRimF7Fl2Ten0XO3xf5vz8mhDLw7ARANjDaANy7-4fJz2kY0LHOXRw7za_cOg47GoTfYu5AN1f3k_rvIA_tmtEc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>194910656</pqid></control><display><type>article</type><title>The interactive effect of the cholinergic system and acute ovarian suppression on the brain: An fMRI study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Craig, M.C. ; Fletcher, P.C. ; Daly, E.M. ; Rymer, J. ; Brammer, M. ; Giampietro, V. ; Stahl, D. ; Maki, P.M. ; Murphy, Declan G.M.</creator><creatorcontrib>Craig, M.C. ; Fletcher, P.C. ; Daly, E.M. ; Rymer, J. ; Brammer, M. ; Giampietro, V. ; Stahl, D. ; Maki, P.M. ; Murphy, Declan G.M.</creatorcontrib><description>Recent evidence suggests that loss of ovarian function following ovariectomy is a risk factor for Alzheimer's disease (AD); however, the biological basis of this risk remains poorly understood. We carried out an
fMRI study into the interaction between loss of ovarian function (after Gonadotropin Hormone Releasing Hormone agonist (GnRHa) treatment) and scopolamine (a cholinergic antagonist used to model the memory decline associated with aging and AD). Behaviorally, cholinergic depletion produced a deficit in verbal recognition performance in both GnRHa-treated women and wait list controls, but only GnRHa-treated women made more false positive errors with cholinergic depletion. Similarly, cholinergic depletion produced a decrease in activation in the left inferior frontal gyrus (LIFG; Brodmann area 45) – a brain region implicated in retrieving word meaning – in both groups, and activation in this area was further reduced following GnRHa treatment. These findings suggest biological mechanisms through which ovarian hormone suppression may interact with the cholinergic system and the LIFG. Furthermore, this interaction may provide a useful model to help explain reports of increased risk for cognitive decline and AD in women following ovariectomy.</description><identifier>ISSN: 0018-506X</identifier><identifier>EISSN: 1095-6867</identifier><identifier>DOI: 10.1016/j.yhbeh.2008.08.008</identifier><identifier>PMID: 18809406</identifier><identifier>CODEN: HOBEAO</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Alzheimer's disease ; Analysis of Variance ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; Brain - drug effects ; Brain - physiology ; Brain Mapping ; Cholinergic Antagonists - pharmacology ; Cholinergic system ; Cognitive ability ; Estrogen ; Female ; fMRI ; Fundamental and applied biological sciences. Psychology ; Gonadotropin-Releasing Hormone - agonists ; Gonadotropin-Releasing Hormone - blood ; Hormones ; Hormones and behavior ; Humans ; Magnetic Resonance Imaging ; Memory ; Middle Aged ; Ovarian hormones ; Ovary - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Recognition, Psychology - drug effects ; Recognition, Psychology - physiology ; Risk factors ; Scopolamine ; Scopolamine - pharmacology ; Semantics ; Womens health</subject><ispartof>Hormones and behavior, 2009, Vol.55 (1), p.41-49</ispartof><rights>2008 Elsevier Inc.</rights><rights>2009 INIST-CNRS</rights><rights>Copyright © 2009 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-4808343fa4ce1d9d32101a78f2a47a88fc4936dab34aac29e181bc3e17d37a283</citedby><cites>FETCH-LOGICAL-c445t-4808343fa4ce1d9d32101a78f2a47a88fc4936dab34aac29e181bc3e17d37a283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.yhbeh.2008.08.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,4010,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21097470$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18809406$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Craig, M.C.</creatorcontrib><creatorcontrib>Fletcher, P.C.</creatorcontrib><creatorcontrib>Daly, E.M.</creatorcontrib><creatorcontrib>Rymer, J.</creatorcontrib><creatorcontrib>Brammer, M.</creatorcontrib><creatorcontrib>Giampietro, V.</creatorcontrib><creatorcontrib>Stahl, D.</creatorcontrib><creatorcontrib>Maki, P.M.</creatorcontrib><creatorcontrib>Murphy, Declan G.M.</creatorcontrib><title>The interactive effect of the cholinergic system and acute ovarian suppression on the brain: An fMRI study</title><title>Hormones and behavior</title><addtitle>Horm Behav</addtitle><description>Recent evidence suggests that loss of ovarian function following ovariectomy is a risk factor for Alzheimer's disease (AD); however, the biological basis of this risk remains poorly understood. We carried out an
fMRI study into the interaction between loss of ovarian function (after Gonadotropin Hormone Releasing Hormone agonist (GnRHa) treatment) and scopolamine (a cholinergic antagonist used to model the memory decline associated with aging and AD). Behaviorally, cholinergic depletion produced a deficit in verbal recognition performance in both GnRHa-treated women and wait list controls, but only GnRHa-treated women made more false positive errors with cholinergic depletion. Similarly, cholinergic depletion produced a decrease in activation in the left inferior frontal gyrus (LIFG; Brodmann area 45) – a brain region implicated in retrieving word meaning – in both groups, and activation in this area was further reduced following GnRHa treatment. These findings suggest biological mechanisms through which ovarian hormone suppression may interact with the cholinergic system and the LIFG. Furthermore, this interaction may provide a useful model to help explain reports of increased risk for cognitive decline and AD in women following ovariectomy.</description><subject>Adult</subject><subject>Alzheimer's disease</subject><subject>Analysis of Variance</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - drug effects</subject><subject>Brain - physiology</subject><subject>Brain Mapping</subject><subject>Cholinergic Antagonists - pharmacology</subject><subject>Cholinergic system</subject><subject>Cognitive ability</subject><subject>Estrogen</subject><subject>Female</subject><subject>fMRI</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gonadotropin-Releasing Hormone - agonists</subject><subject>Gonadotropin-Releasing Hormone - blood</subject><subject>Hormones</subject><subject>Hormones and behavior</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Memory</subject><subject>Middle Aged</subject><subject>Ovarian hormones</subject><subject>Ovary - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Recognition, Psychology - drug effects</subject><subject>Recognition, Psychology - physiology</subject><subject>Risk factors</subject><subject>Scopolamine</subject><subject>Scopolamine - pharmacology</subject><subject>Semantics</subject><subject>Womens health</subject><issn>0018-506X</issn><issn>1095-6867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkW-L1DAQxoMo3nr6CQQJgr7rXtKmaSrci-Pwz8EdgpzguzBNJ25KN12TdGG__aXuouALDx4YhvnNMDMPIa85W3PG5cWwPmw63KxLxtR6EVNPyIqzti6kks1TsmKMq6Jm8scZeRHjkFNeC_GcnHGlWCuYXJHhfoPU-YQBTHJ7pGgtmkQnS1OumM00Oo_hpzM0HmLCLQXfUzBzQjrtITjwNM67XcAY3eRp1tLXBXD-A73y1N59u6Exzf3hJXlmYYz46hTPyfdPH--vvxS3Xz_fXF_dFkaIOhVCMVWJyoIwyPu2r8p8LTTKliAaUMoa0Vayh64SAKZskSvemQp501cNlKo6J--Pc3dh-jVjTHrrosFxBI_THLWUipdM8EfBkpVNXTYL-PYfcJjm4PMRmrei5UzWMkPVETJhijGg1bvgthAOmjO9GKYH_dswvRimF7Fl2Ten0XO3xf5vz8mhDLw7ARANjDaANy7-4fJz2kY0LHOXRw7za_cOg47GoTfYu5AN1f3k_rvIA_tmtEc</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Craig, M.C.</creator><creator>Fletcher, P.C.</creator><creator>Daly, E.M.</creator><creator>Rymer, J.</creator><creator>Brammer, M.</creator><creator>Giampietro, V.</creator><creator>Stahl, D.</creator><creator>Maki, P.M.</creator><creator>Murphy, Declan G.M.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier BV</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>2009</creationdate><title>The interactive effect of the cholinergic system and acute ovarian suppression on the brain: An fMRI study</title><author>Craig, M.C. ; Fletcher, P.C. ; Daly, E.M. ; Rymer, J. ; Brammer, M. ; Giampietro, V. ; Stahl, D. ; Maki, P.M. ; Murphy, Declan G.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-4808343fa4ce1d9d32101a78f2a47a88fc4936dab34aac29e181bc3e17d37a283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Alzheimer's disease</topic><topic>Analysis of Variance</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - drug effects</topic><topic>Brain - physiology</topic><topic>Brain Mapping</topic><topic>Cholinergic Antagonists - pharmacology</topic><topic>Cholinergic system</topic><topic>Cognitive ability</topic><topic>Estrogen</topic><topic>Female</topic><topic>fMRI</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gonadotropin-Releasing Hormone - agonists</topic><topic>Gonadotropin-Releasing Hormone - blood</topic><topic>Hormones</topic><topic>Hormones and behavior</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Memory</topic><topic>Middle Aged</topic><topic>Ovarian hormones</topic><topic>Ovary - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Recognition, Psychology - drug effects</topic><topic>Recognition, Psychology - physiology</topic><topic>Risk factors</topic><topic>Scopolamine</topic><topic>Scopolamine - pharmacology</topic><topic>Semantics</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Craig, M.C.</creatorcontrib><creatorcontrib>Fletcher, P.C.</creatorcontrib><creatorcontrib>Daly, E.M.</creatorcontrib><creatorcontrib>Rymer, J.</creatorcontrib><creatorcontrib>Brammer, M.</creatorcontrib><creatorcontrib>Giampietro, V.</creatorcontrib><creatorcontrib>Stahl, D.</creatorcontrib><creatorcontrib>Maki, P.M.</creatorcontrib><creatorcontrib>Murphy, Declan G.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Hormones and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Craig, M.C.</au><au>Fletcher, P.C.</au><au>Daly, E.M.</au><au>Rymer, J.</au><au>Brammer, M.</au><au>Giampietro, V.</au><au>Stahl, D.</au><au>Maki, P.M.</au><au>Murphy, Declan G.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The interactive effect of the cholinergic system and acute ovarian suppression on the brain: An fMRI study</atitle><jtitle>Hormones and behavior</jtitle><addtitle>Horm Behav</addtitle><date>2009</date><risdate>2009</risdate><volume>55</volume><issue>1</issue><spage>41</spage><epage>49</epage><pages>41-49</pages><issn>0018-506X</issn><eissn>1095-6867</eissn><coden>HOBEAO</coden><abstract>Recent evidence suggests that loss of ovarian function following ovariectomy is a risk factor for Alzheimer's disease (AD); however, the biological basis of this risk remains poorly understood. We carried out an
fMRI study into the interaction between loss of ovarian function (after Gonadotropin Hormone Releasing Hormone agonist (GnRHa) treatment) and scopolamine (a cholinergic antagonist used to model the memory decline associated with aging and AD). Behaviorally, cholinergic depletion produced a deficit in verbal recognition performance in both GnRHa-treated women and wait list controls, but only GnRHa-treated women made more false positive errors with cholinergic depletion. Similarly, cholinergic depletion produced a decrease in activation in the left inferior frontal gyrus (LIFG; Brodmann area 45) – a brain region implicated in retrieving word meaning – in both groups, and activation in this area was further reduced following GnRHa treatment. These findings suggest biological mechanisms through which ovarian hormone suppression may interact with the cholinergic system and the LIFG. Furthermore, this interaction may provide a useful model to help explain reports of increased risk for cognitive decline and AD in women following ovariectomy.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>18809406</pmid><doi>10.1016/j.yhbeh.2008.08.008</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0018-506X |
| ispartof | Hormones and behavior, 2009, Vol.55 (1), p.41-49 |
| issn | 0018-506X 1095-6867 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66812041 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Alzheimer's disease Analysis of Variance Behavioral psychophysiology Biological and medical sciences Brain Brain - drug effects Brain - physiology Brain Mapping Cholinergic Antagonists - pharmacology Cholinergic system Cognitive ability Estrogen Female fMRI Fundamental and applied biological sciences. Psychology Gonadotropin-Releasing Hormone - agonists Gonadotropin-Releasing Hormone - blood Hormones Hormones and behavior Humans Magnetic Resonance Imaging Memory Middle Aged Ovarian hormones Ovary - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Recognition, Psychology - drug effects Recognition, Psychology - physiology Risk factors Scopolamine Scopolamine - pharmacology Semantics Womens health |
| title | The interactive effect of the cholinergic system and acute ovarian suppression on the brain: An fMRI study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T12%3A33%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20interactive%20effect%20of%20the%20cholinergic%20system%20and%20acute%20ovarian%20suppression%20on%20the%20brain:%20An%20fMRI%20study&rft.jtitle=Hormones%20and%20behavior&rft.au=Craig,%20M.C.&rft.date=2009&rft.volume=55&rft.issue=1&rft.spage=41&rft.epage=49&rft.pages=41-49&rft.issn=0018-506X&rft.eissn=1095-6867&rft.coden=HOBEAO&rft_id=info:doi/10.1016/j.yhbeh.2008.08.008&rft_dat=%3Cproquest_cross%3E66812041%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=194910656&rft_id=info:pmid/18809406&rft_els_id=S0018506X0800247X&rfr_iscdi=true |