Regional reductions of gray matter volume in familial dyslexia

Regional reductions of gray matter volume in familial dyslexia

An in vivo anatomic study of gray matter volume was performed in a group of familial dyslexic individuals, using an optimized method of voxel-based morphometry. Focal abnormalities in gray matter volume were observed bilaterally in the planum temporale, inferior temporal cortex, and cerebellar nucle...

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Veröffentlicht in:Neurology 2004-08, Vol.63 (4), p.742-745
Hauptverfasser: BRAMBATI, S. M, TERMINE, C, RUFFINO, M, STELLA, G, FAZIO, F, CAPPA, S. F, PERANI, D
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Biological and medical sciences
Cerebellar Nuclei - pathology
Dyslexia - genetics
Dyslexia - pathology
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Neurology
Neuropsychological Tests
Organ Size
Temporal Lobe - pathology
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Zusammenfassung:An in vivo anatomic study of gray matter volume was performed in a group of familial dyslexic individuals, using an optimized method of voxel-based morphometry. Focal abnormalities in gray matter volume were observed bilaterally in the planum temporale, inferior temporal cortex, and cerebellar nuclei, suggesting that the underlying anatomic abnormalities may be responsible for defective written language acquisition in these subjects.
ISSN:0028-3878
1526-632X
DOI:10.1212/01.WNL.0000134673.95020.EE