Chemical composition and mechanisms underlying the spasmolytic and bronchodilatory properties of the essential oil of Nepeta cataria L
The study was aimed to investigate the chemical composition and pharmacological basis for traditional use of essential oil of Nepeta cataria L. (Limiaceae) (Nc.Oil) in gastrointestinal and respiratory disorders. Chemical analysis was carried out through GC-EIMS, 13C NMR and Kovats Retention Indices...
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| Veröffentlicht in: | Journal of ethnopharmacology 2009-01, Vol.121 (3), p.405-411 |
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| container_title | Journal of ethnopharmacology |
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| creator | Gilani, Anwar H. Shah, Abdul J. Zubair, Amina Khalid, Sana Kiani, Jawad Ahmed, Amir Rasheed, Munawwer Ahmad, Viqar U. |
| description | The study was aimed to investigate the chemical composition and pharmacological basis for traditional use of essential oil of
Nepeta cataria L. (Limiaceae) (Nc.Oil) in gastrointestinal and respiratory disorders.
Chemical analysis was carried out through GC-EIMS,
13C NMR and Kovats Retention Indices while pharmacological study was carried out in isolated tissues preparations.
Four major components; 1,8-cineol (21.00%), α-humulene (14.44%), α-pinene (10.43%) and geranyl acetate (8.21%) were identified among the 27 compounds in Nc.Oil. In isolated rabbit jejunum, Nc.Oil, papaverine and verapamil inhibited spontaneous and high K
+(80
mM) precontractions, as well as shifted the Ca
++ concentration–response curves (CRCs) to right, indicating calcium channel blocking activity. In isolated guinea-pig trachea, Nc.Oil and papaverine inhibited carbachol (1
μM) and K
+ precontractions with similar potency, while verapamil was more potent against K
+. Nc.Oil also potentiated isoprenaline inhibitory CRCs, similar to papaverine, indicating papaverine-like PDE inhibitor activity. In isolated guinea-pig atria, Nc.Oil caused cardiodepression at around 25–80 times higher concentrations, similar to papaverine.
These data indicate that
Nepeta cataria possesses spasmolytic and myorelaxant activities mediated possibly through dual inhibition of calcium channels and PDE, which may explain its traditional use in colic, diarrhea, cough and asthma. |
| doi_str_mv | 10.1016/j.jep.2008.11.004 |
| format | Article |
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Nepeta cataria L. (Limiaceae) (Nc.Oil) in gastrointestinal and respiratory disorders.
Chemical analysis was carried out through GC-EIMS,
13C NMR and Kovats Retention Indices while pharmacological study was carried out in isolated tissues preparations.
Four major components; 1,8-cineol (21.00%), α-humulene (14.44%), α-pinene (10.43%) and geranyl acetate (8.21%) were identified among the 27 compounds in Nc.Oil. In isolated rabbit jejunum, Nc.Oil, papaverine and verapamil inhibited spontaneous and high K
+(80
mM) precontractions, as well as shifted the Ca
++ concentration–response curves (CRCs) to right, indicating calcium channel blocking activity. In isolated guinea-pig trachea, Nc.Oil and papaverine inhibited carbachol (1
μM) and K
+ precontractions with similar potency, while verapamil was more potent against K
+. Nc.Oil also potentiated isoprenaline inhibitory CRCs, similar to papaverine, indicating papaverine-like PDE inhibitor activity. In isolated guinea-pig atria, Nc.Oil caused cardiodepression at around 25–80 times higher concentrations, similar to papaverine.
These data indicate that
Nepeta cataria possesses spasmolytic and myorelaxant activities mediated possibly through dual inhibition of calcium channels and PDE, which may explain its traditional use in colic, diarrhea, cough and asthma.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2008.11.004</identifier><identifier>PMID: 19041706</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Asthma ; Bronchodilator Agents - pharmacology ; Calcium antagonist ; Calcium Channels - drug effects ; Chemical composition ; Colic ; Essential oil ; Female ; Guinea Pigs ; Male ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Nepeta ; Nepeta cataria L ; Oils, Volatile - chemistry ; Oils, Volatile - pharmacology ; Papaverine - pharmacology ; Parasympatholytics - pharmacology ; PDE inhibition ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Rabbits ; Verapamil - pharmacology</subject><ispartof>Journal of ethnopharmacology, 2009-01, Vol.121 (3), p.405-411</ispartof><rights>2008 Elsevier Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-c18e3773890ddd415cf5652e6c55422ed7133c81cc5f8b3a4a71c876df9d8f093</citedby><cites>FETCH-LOGICAL-c417t-c18e3773890ddd415cf5652e6c55422ed7133c81cc5f8b3a4a71c876df9d8f093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2008.11.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19041706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gilani, Anwar H.</creatorcontrib><creatorcontrib>Shah, Abdul J.</creatorcontrib><creatorcontrib>Zubair, Amina</creatorcontrib><creatorcontrib>Khalid, Sana</creatorcontrib><creatorcontrib>Kiani, Jawad</creatorcontrib><creatorcontrib>Ahmed, Amir</creatorcontrib><creatorcontrib>Rasheed, Munawwer</creatorcontrib><creatorcontrib>Ahmad, Viqar U.</creatorcontrib><title>Chemical composition and mechanisms underlying the spasmolytic and bronchodilatory properties of the essential oil of Nepeta cataria L</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The study was aimed to investigate the chemical composition and pharmacological basis for traditional use of essential oil of
Nepeta cataria L. (Limiaceae) (Nc.Oil) in gastrointestinal and respiratory disorders.
Chemical analysis was carried out through GC-EIMS,
13C NMR and Kovats Retention Indices while pharmacological study was carried out in isolated tissues preparations.
Four major components; 1,8-cineol (21.00%), α-humulene (14.44%), α-pinene (10.43%) and geranyl acetate (8.21%) were identified among the 27 compounds in Nc.Oil. In isolated rabbit jejunum, Nc.Oil, papaverine and verapamil inhibited spontaneous and high K
+(80
mM) precontractions, as well as shifted the Ca
++ concentration–response curves (CRCs) to right, indicating calcium channel blocking activity. In isolated guinea-pig trachea, Nc.Oil and papaverine inhibited carbachol (1
μM) and K
+ precontractions with similar potency, while verapamil was more potent against K
+. Nc.Oil also potentiated isoprenaline inhibitory CRCs, similar to papaverine, indicating papaverine-like PDE inhibitor activity. In isolated guinea-pig atria, Nc.Oil caused cardiodepression at around 25–80 times higher concentrations, similar to papaverine.
These data indicate that
Nepeta cataria possesses spasmolytic and myorelaxant activities mediated possibly through dual inhibition of calcium channels and PDE, which may explain its traditional use in colic, diarrhea, cough and asthma.</description><subject>Animals</subject><subject>Asthma</subject><subject>Bronchodilator Agents - pharmacology</subject><subject>Calcium antagonist</subject><subject>Calcium Channels - drug effects</subject><subject>Chemical composition</subject><subject>Colic</subject><subject>Essential oil</subject><subject>Female</subject><subject>Guinea Pigs</subject><subject>Male</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Nepeta</subject><subject>Nepeta cataria L</subject><subject>Oils, Volatile - chemistry</subject><subject>Oils, Volatile - pharmacology</subject><subject>Papaverine - pharmacology</subject><subject>Parasympatholytics - pharmacology</subject><subject>PDE inhibition</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Rabbits</subject><subject>Verapamil - pharmacology</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMuOEzEQRS0EYsLAB7BBXrHrxtUvu8UKRcNDimADa8spVxNH3XZjO0j5Ab4bZxKJHauSrHNvlQ9jr0HUIGB4d6yPtNaNEKoGqIXonrANKNlUspftU7YRrVSVkh3csRcpHYUQEjrxnN3BKDqQYtiwP9sDLQ7NzDEsa0guu-C58ZYvhAfjXVoSP3lLcT47_5PnA_G0mrSE-ZwdPpL7GDwegnWzySGe-RrDSjE7SjxMjwlKiXx2ZUtw8-XxK62UDUeTTXSG716yZ5OZE726zXv24-PD9-3navft05fth12F5d5cIShqpWzVKKy1HfQ49UPf0IB93zUNWQltiwoQ-0ntW9MZCajkYKfRqkmM7T17e-0tN_46Ucp6cQlpno2ncEp6GJQYB-gKCFcQY0gp0qTX6BYTzxqEvsjXR13k64t8DaCL_JJ5cys_7Rey_xI32wV4fwWofPG3o6gTOvJI1kXCrG1w_6n_C5mtl-E</recordid><startdate>20090130</startdate><enddate>20090130</enddate><creator>Gilani, Anwar H.</creator><creator>Shah, Abdul J.</creator><creator>Zubair, Amina</creator><creator>Khalid, Sana</creator><creator>Kiani, Jawad</creator><creator>Ahmed, Amir</creator><creator>Rasheed, Munawwer</creator><creator>Ahmad, Viqar U.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090130</creationdate><title>Chemical composition and mechanisms underlying the spasmolytic and bronchodilatory properties of the essential oil of Nepeta cataria L</title><author>Gilani, Anwar H. ; Shah, Abdul J. ; Zubair, Amina ; Khalid, Sana ; Kiani, Jawad ; Ahmed, Amir ; Rasheed, Munawwer ; Ahmad, Viqar U.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-c18e3773890ddd415cf5652e6c55422ed7133c81cc5f8b3a4a71c876df9d8f093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Asthma</topic><topic>Bronchodilator Agents - pharmacology</topic><topic>Calcium antagonist</topic><topic>Calcium Channels - drug effects</topic><topic>Chemical composition</topic><topic>Colic</topic><topic>Essential oil</topic><topic>Female</topic><topic>Guinea Pigs</topic><topic>Male</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Nepeta</topic><topic>Nepeta cataria L</topic><topic>Oils, Volatile - chemistry</topic><topic>Oils, Volatile - pharmacology</topic><topic>Papaverine - pharmacology</topic><topic>Parasympatholytics - pharmacology</topic><topic>PDE inhibition</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Rabbits</topic><topic>Verapamil - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gilani, Anwar H.</creatorcontrib><creatorcontrib>Shah, Abdul J.</creatorcontrib><creatorcontrib>Zubair, Amina</creatorcontrib><creatorcontrib>Khalid, Sana</creatorcontrib><creatorcontrib>Kiani, Jawad</creatorcontrib><creatorcontrib>Ahmed, Amir</creatorcontrib><creatorcontrib>Rasheed, Munawwer</creatorcontrib><creatorcontrib>Ahmad, Viqar U.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gilani, Anwar H.</au><au>Shah, Abdul J.</au><au>Zubair, Amina</au><au>Khalid, Sana</au><au>Kiani, Jawad</au><au>Ahmed, Amir</au><au>Rasheed, Munawwer</au><au>Ahmad, Viqar U.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical composition and mechanisms underlying the spasmolytic and bronchodilatory properties of the essential oil of Nepeta cataria L</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2009-01-30</date><risdate>2009</risdate><volume>121</volume><issue>3</issue><spage>405</spage><epage>411</epage><pages>405-411</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>The study was aimed to investigate the chemical composition and pharmacological basis for traditional use of essential oil of
Nepeta cataria L. (Limiaceae) (Nc.Oil) in gastrointestinal and respiratory disorders.
Chemical analysis was carried out through GC-EIMS,
13C NMR and Kovats Retention Indices while pharmacological study was carried out in isolated tissues preparations.
Four major components; 1,8-cineol (21.00%), α-humulene (14.44%), α-pinene (10.43%) and geranyl acetate (8.21%) were identified among the 27 compounds in Nc.Oil. In isolated rabbit jejunum, Nc.Oil, papaverine and verapamil inhibited spontaneous and high K
+(80
mM) precontractions, as well as shifted the Ca
++ concentration–response curves (CRCs) to right, indicating calcium channel blocking activity. In isolated guinea-pig trachea, Nc.Oil and papaverine inhibited carbachol (1
μM) and K
+ precontractions with similar potency, while verapamil was more potent against K
+. Nc.Oil also potentiated isoprenaline inhibitory CRCs, similar to papaverine, indicating papaverine-like PDE inhibitor activity. In isolated guinea-pig atria, Nc.Oil caused cardiodepression at around 25–80 times higher concentrations, similar to papaverine.
These data indicate that
Nepeta cataria possesses spasmolytic and myorelaxant activities mediated possibly through dual inhibition of calcium channels and PDE, which may explain its traditional use in colic, diarrhea, cough and asthma.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>19041706</pmid><doi>10.1016/j.jep.2008.11.004</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2009-01, Vol.121 (3), p.405-411 |
| issn | 0378-8741 1872-7573 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Asthma Bronchodilator Agents - pharmacology Calcium antagonist Calcium Channels - drug effects Chemical composition Colic Essential oil Female Guinea Pigs Male Muscle Contraction - drug effects Muscle, Smooth - drug effects Nepeta Nepeta cataria L Oils, Volatile - chemistry Oils, Volatile - pharmacology Papaverine - pharmacology Parasympatholytics - pharmacology PDE inhibition Plant Extracts - chemistry Plant Extracts - pharmacology Rabbits Verapamil - pharmacology |
| title | Chemical composition and mechanisms underlying the spasmolytic and bronchodilatory properties of the essential oil of Nepeta cataria L |
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