UA62784, a novel inhibitor of centromere protein E kinesin-like protein

Pancreatic carcinoma is the fourth leading cause of death from cancer. Novel targets and therapeutic options are needed to aid in the treatment of pancreatic cancer. The compound UA62784 is a novel fluorenone with inhibitory activity against the centromere protein E (CENP-E) kinesin-like protein. UA...

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Veröffentlicht in:	Molecular cancer therapeutics 2009-01, Vol.8 (1), p.36-44
Hauptverfasser:	Henderson, Meredith C, Shaw, Yeng-Jeng Y, Wang, Hong, Han, Haiyong, Hurley, Laurence H, Flynn, Gary, Dorr, Robert T, Von Hoff, Daniel D
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects cancer Cell Line, Tumor CENP-E Chromosomal Proteins, Non-Histone - antagonists & inhibitors Chromosomal Proteins, Non-Histone - metabolism DPC4 Humans kinesin Kinesin - antagonists & inhibitors Kinesin - classification Kinesin - metabolism Microtubules - drug effects Microtubules - metabolism Molecular Structure Oxazoles - chemistry Oxazoles - pharmacology pancreatic Protein Binding Tubulin - metabolism Xanthones - chemistry Xanthones - pharmacology
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