Angiotensin I-converting enzyme-like activity in tissues from the Atlantic hagfish ( Myxine glutinosa) and detection of immunoreactive plasma angiotensins
Using a highly sensitive fluorimetric assay, significant levels of angiotensin I -converting enzyme-like activity (ACELA) were detected in a range of tissues (branchial heart, gill, kidney with associated vasculature and archinephric duct, liver, whole brain and gut) from the Atlantic hagfish ( Myxi...
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| Veröffentlicht in: | Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2004-08, Vol.138 (4), p.357-364 |
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| container_title | Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology |
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| creator | Cobb, Christopher S. Frankling, Susan C. Thorndyke, Mike C. Jensen, Frank B. Rankin, J.Cliff Brown, J.Anne |
| description | Using a highly sensitive fluorimetric assay, significant levels of angiotensin I -converting enzyme-like activity (ACELA) were detected in a range of tissues (branchial heart, gill, kidney with associated vasculature and archinephric duct, liver, whole brain and gut) from the Atlantic hagfish (
Myxine glutinosa). The highest ACELA occurred in heart and gill (1.8 and 1.5 nmol His–Leu min
−1 mg protein
−1, respectively). The mammalian angiotensin I-converting enzyme (ACE) inhibitor, captopril, at 10
−5 M was a potent inhibitor of the ACELA found in all hagfish tissues. Radioimmunoassay showed that immunoreactive angiotensins (251.8±11.8 pM) were detectable in hagfish plasma. The validity of the assay for measurement of hagfish angiotensins was indicated by the parallelism of the angiotensin II standard curve against serially diluted hagfish plasma. Measurement of immunoreactive plasma angiotensins and detection of significant levels of ACELA in a wide range of tissues gives indirect evidence for the presence of a renin–angiotensin system in hagfishes, the earliest evolved group of craniates. |
| doi_str_mv | 10.1016/j.cbpc.2004.04.015 |
| format | Article |
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Myxine glutinosa). The highest ACELA occurred in heart and gill (1.8 and 1.5 nmol His–Leu min
−1 mg protein
−1, respectively). The mammalian angiotensin I-converting enzyme (ACE) inhibitor, captopril, at 10
−5 M was a potent inhibitor of the ACELA found in all hagfish tissues. Radioimmunoassay showed that immunoreactive angiotensins (251.8±11.8 pM) were detectable in hagfish plasma. The validity of the assay for measurement of hagfish angiotensins was indicated by the parallelism of the angiotensin II standard curve against serially diluted hagfish plasma. Measurement of immunoreactive plasma angiotensins and detection of significant levels of ACELA in a wide range of tissues gives indirect evidence for the presence of a renin–angiotensin system in hagfishes, the earliest evolved group of craniates.</description><identifier>ISSN: 1096-4959</identifier><identifier>EISSN: 1879-1107</identifier><identifier>DOI: 10.1016/j.cbpc.2004.04.015</identifier><identifier>PMID: 15325335</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Angiotensin I-converting enzyme ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; Angiotensins ; Angiotensins - blood ; Angiotensins - chemistry ; Animals ; Atlantic hagfish ; Captopril - pharmacology ; Dose-Response Relationship, Drug ; Ecology ; Ekologi ; Hagfishes ; Microscopy, Fluorescence ; Myxine glutinosa ; Peptidyl-Dipeptidase A - metabolism ; Radioimmunoassay ; Renin–angiotensin system ; Tissue Distribution</subject><ispartof>Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2004-08, Vol.138 (4), p.357-364</ispartof><rights>2004 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-d4e8370d84c9d8b50c1e57695d325b6d578c57fe24c80d7a2b92806af58377233</citedby><cites>FETCH-LOGICAL-c389t-d4e8370d84c9d8b50c1e57695d325b6d578c57fe24c80d7a2b92806af58377233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cbpc.2004.04.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15325335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/59168$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Cobb, Christopher S.</creatorcontrib><creatorcontrib>Frankling, Susan C.</creatorcontrib><creatorcontrib>Thorndyke, Mike C.</creatorcontrib><creatorcontrib>Jensen, Frank B.</creatorcontrib><creatorcontrib>Rankin, J.Cliff</creatorcontrib><creatorcontrib>Brown, J.Anne</creatorcontrib><title>Angiotensin I-converting enzyme-like activity in tissues from the Atlantic hagfish ( Myxine glutinosa) and detection of immunoreactive plasma angiotensins</title><title>Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology</title><addtitle>Comp Biochem Physiol B Biochem Mol Biol</addtitle><description>Using a highly sensitive fluorimetric assay, significant levels of angiotensin I -converting enzyme-like activity (ACELA) were detected in a range of tissues (branchial heart, gill, kidney with associated vasculature and archinephric duct, liver, whole brain and gut) from the Atlantic hagfish (
Myxine glutinosa). The highest ACELA occurred in heart and gill (1.8 and 1.5 nmol His–Leu min
−1 mg protein
−1, respectively). The mammalian angiotensin I-converting enzyme (ACE) inhibitor, captopril, at 10
−5 M was a potent inhibitor of the ACELA found in all hagfish tissues. Radioimmunoassay showed that immunoreactive angiotensins (251.8±11.8 pM) were detectable in hagfish plasma. The validity of the assay for measurement of hagfish angiotensins was indicated by the parallelism of the angiotensin II standard curve against serially diluted hagfish plasma. Measurement of immunoreactive plasma angiotensins and detection of significant levels of ACELA in a wide range of tissues gives indirect evidence for the presence of a renin–angiotensin system in hagfishes, the earliest evolved group of craniates.</description><subject>Angiotensin I-converting enzyme</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>Angiotensins</subject><subject>Angiotensins - blood</subject><subject>Angiotensins - chemistry</subject><subject>Animals</subject><subject>Atlantic hagfish</subject><subject>Captopril - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ecology</subject><subject>Ekologi</subject><subject>Hagfishes</subject><subject>Microscopy, Fluorescence</subject><subject>Myxine glutinosa</subject><subject>Peptidyl-Dipeptidase A - metabolism</subject><subject>Radioimmunoassay</subject><subject>Renin–angiotensin system</subject><subject>Tissue Distribution</subject><issn>1096-4959</issn><issn>1879-1107</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd2O1CAYhonRuLujN-CB4ci4iR2hDC1N9mSy8WeTNZ7oMaHwtcPYQgU6Ol6KVyt1JuuZCQmEPN8TeF-EXlCypoRWb_dr3U56XRKyWS-L8kfokoq6KSgl9eN8Jk1VbBreXKCrGPeEMEEZfYouKGclZ4xfot9b11ufwEXr8F2hvTtASNb1GNyv4wjFYL8BVjrZg01HnKFkY5wh4i74Eacd4G0alEtW453qOxt3-DX-dPxpHeB-mLPKR3WNlTPYQIIs8g77DttxnJ0P8FcNeBpUHFXGHl4Tn6EnnRoiPD_vK_T1_bsvtx-L-88f7m6394VmokmF2YBgNTFioxsjWk40BV5XDTf5j21leC00rzsoN1oQU6uybUpBKtXxPFaXjK3Qm5M3_oBpbuUU7KjCUXplZT9PMl_1s4wgeUMrkfFXJ3wK_nsOIsnRRg1DDgH8HGVVCSIEIxksT6AOPsYA3YOZErkUKPdyKVAuBcpl5VpW6OXZPrcjmH8j58YycHMCIEdysBBk1BacBmNDTlcab__n_wO4CbAd</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Cobb, Christopher S.</creator><creator>Frankling, Susan C.</creator><creator>Thorndyke, Mike C.</creator><creator>Jensen, Frank B.</creator><creator>Rankin, J.Cliff</creator><creator>Brown, J.Anne</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>F1U</scope></search><sort><creationdate>20040801</creationdate><title>Angiotensin I-converting enzyme-like activity in tissues from the Atlantic hagfish ( Myxine glutinosa) and detection of immunoreactive plasma angiotensins</title><author>Cobb, Christopher S. ; Frankling, Susan C. ; Thorndyke, Mike C. ; Jensen, Frank B. ; Rankin, J.Cliff ; Brown, J.Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-d4e8370d84c9d8b50c1e57695d325b6d578c57fe24c80d7a2b92806af58377233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Angiotensin I-converting enzyme</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacology</topic><topic>Angiotensins</topic><topic>Angiotensins - blood</topic><topic>Angiotensins - chemistry</topic><topic>Animals</topic><topic>Atlantic hagfish</topic><topic>Captopril - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ecology</topic><topic>Ekologi</topic><topic>Hagfishes</topic><topic>Microscopy, Fluorescence</topic><topic>Myxine glutinosa</topic><topic>Peptidyl-Dipeptidase A - metabolism</topic><topic>Radioimmunoassay</topic><topic>Renin–angiotensin system</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cobb, Christopher S.</creatorcontrib><creatorcontrib>Frankling, Susan C.</creatorcontrib><creatorcontrib>Thorndyke, Mike C.</creatorcontrib><creatorcontrib>Jensen, Frank B.</creatorcontrib><creatorcontrib>Rankin, J.Cliff</creatorcontrib><creatorcontrib>Brown, J.Anne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Göteborgs universitet</collection><jtitle>Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cobb, Christopher S.</au><au>Frankling, Susan C.</au><au>Thorndyke, Mike C.</au><au>Jensen, Frank B.</au><au>Rankin, J.Cliff</au><au>Brown, J.Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensin I-converting enzyme-like activity in tissues from the Atlantic hagfish ( Myxine glutinosa) and detection of immunoreactive plasma angiotensins</atitle><jtitle>Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology</jtitle><addtitle>Comp Biochem Physiol B Biochem Mol Biol</addtitle><date>2004-08-01</date><risdate>2004</risdate><volume>138</volume><issue>4</issue><spage>357</spage><epage>364</epage><pages>357-364</pages><issn>1096-4959</issn><eissn>1879-1107</eissn><abstract>Using a highly sensitive fluorimetric assay, significant levels of angiotensin I -converting enzyme-like activity (ACELA) were detected in a range of tissues (branchial heart, gill, kidney with associated vasculature and archinephric duct, liver, whole brain and gut) from the Atlantic hagfish (
Myxine glutinosa). The highest ACELA occurred in heart and gill (1.8 and 1.5 nmol His–Leu min
−1 mg protein
−1, respectively). The mammalian angiotensin I-converting enzyme (ACE) inhibitor, captopril, at 10
−5 M was a potent inhibitor of the ACELA found in all hagfish tissues. Radioimmunoassay showed that immunoreactive angiotensins (251.8±11.8 pM) were detectable in hagfish plasma. The validity of the assay for measurement of hagfish angiotensins was indicated by the parallelism of the angiotensin II standard curve against serially diluted hagfish plasma. Measurement of immunoreactive plasma angiotensins and detection of significant levels of ACELA in a wide range of tissues gives indirect evidence for the presence of a renin–angiotensin system in hagfishes, the earliest evolved group of craniates.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>15325335</pmid><doi>10.1016/j.cbpc.2004.04.015</doi><tpages>8</tpages></addata></record> |
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| ispartof | Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2004-08, Vol.138 (4), p.357-364 |
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| subjects | Angiotensin I-converting enzyme Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensins Angiotensins - blood Angiotensins - chemistry Animals Atlantic hagfish Captopril - pharmacology Dose-Response Relationship, Drug Ecology Ekologi Hagfishes Microscopy, Fluorescence Myxine glutinosa Peptidyl-Dipeptidase A - metabolism Radioimmunoassay Renin–angiotensin system Tissue Distribution |
| title | Angiotensin I-converting enzyme-like activity in tissues from the Atlantic hagfish ( Myxine glutinosa) and detection of immunoreactive plasma angiotensins |
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