Simulation of Domain Formation in DLPC−DSPC Mixed Bilayers

Simulation of Domain Formation in DLPC−DSPC Mixed Bilayers

Binary mixtures of two phosphatidylcholines of different chain lengths are simulated in the bilayer state. We find a phase transition between a liquid state and a gel state at all concentrations. This phase transition is characterized by the area per lipid headgroup, the order parameter, and a chang...

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Veröffentlicht in:Langmuir 2004-08, Vol.20 (18), p.7686-7693
Hauptverfasser: Faller, Roland, Marrink, Siewert-Jan
Format: Artikel
Sprache:eng
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Dimyristoylphosphatidylcholine - chemistry
Membrane Lipids - chemistry
Membrane Microdomains - chemistry
Models, Molecular
Phase Transition
Phosphatidylcholines - chemistry
Surface Properties
Temperature
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Marrink, Siewert-Jan
description Binary mixtures of two phosphatidylcholines of different chain lengths are simulated in the bilayer state. We find a phase transition between a liquid state and a gel state at all concentrations. This phase transition is characterized by the area per lipid headgroup, the order parameter, and a change in dynamics. At concentrations with a majority of the longer lipid, we find phase separation into a gel and a liquid state in a small temperature window. This leads to a strong dynamic heterogeneity. Experimental phase transition temperatures are reproduced semiquantitatively. We see a clear shift in the phase transition to higher temperatures with increasing concentration of the longer lipid.
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subjects Dimyristoylphosphatidylcholine - chemistry
Membrane Lipids - chemistry
Membrane Microdomains - chemistry
Models, Molecular
Phase Transition
Phosphatidylcholines - chemistry
Surface Properties
Temperature
title Simulation of Domain Formation in DLPC−DSPC Mixed Bilayers
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