Screening of antiplasmodial properties among some traditionally used Iranian plants
An investigation of plants was undertaken through interviews and literature surveys on plants used to treat malaria or cancer or microbial diseases in Iran. In vitro and in vivo antiplasmodial tests were carried out on selected plants traditionally used in Iran. Thirty-two plants were extracted with...
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| Veröffentlicht in: | Journal of ethnopharmacology 2009-01, Vol.121 (3), p.400-404 |
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| creator | Esmaeili, Somayeh Naghibi, Farzaneh Mosaddegh, Mahmoud Sahranavard, Shamim Ghafari, Saeideh Abdullah, Noor Rain |
| description | An investigation of plants was undertaken through interviews and literature surveys on plants used to treat malaria or cancer or microbial diseases in Iran.
In vitro and
in vivo antiplasmodial tests were carried out on selected plants traditionally used in Iran.
Thirty-two plants were extracted with methanol and tested for their
in vitro (pLDH assay) activity against
Plasmodium falciparum,
in vivo activity against
Plasmodium berghei and assessed for any cytotoxicity against the human cancer cell line MCF7 and the normal cell MDBK.
Extracts from four plants,
Buxus hyrcana Pojark. (Buxaceae),
Erodium oxyrrhnchum M. Bieb. (Geraniaceae),
Glycyrrhiza glabra L. (Fabaceae) and
Ferula oopoda (Boiss and Bushe) Boiss. (Apiaceae) were found to have significant antiplasmodial activity (IC
50 ranging from 4.7 to 26.6
μg/ml). These findings lend support to the use of
Buxus hyrcana and
Glycyrrhiza glabra in traditional medicine. The chloroformic fraction also was active against K1 and 3D7 strains. The chloroformic fraction was studied at 10
mg per kg body weight mouse per day. This fraction reduced parasitaemia by 86.1% compared to untreated control mice.
Glycyrrhiza glabra showed antiplasmodial activity and has selectivity for
Plasmodium falciparum and
Plasmodium berghei when tested on mammalian cells. This is the first report that mentioned
in vitro and
in vivo antiplasmodial activity of
Glycyrrhiza glabra. |
| doi_str_mv | 10.1016/j.jep.2008.10.041 |
| format | Article |
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In vitro and
in vivo antiplasmodial tests were carried out on selected plants traditionally used in Iran.
Thirty-two plants were extracted with methanol and tested for their
in vitro (pLDH assay) activity against
Plasmodium falciparum,
in vivo activity against
Plasmodium berghei and assessed for any cytotoxicity against the human cancer cell line MCF7 and the normal cell MDBK.
Extracts from four plants,
Buxus hyrcana Pojark. (Buxaceae),
Erodium oxyrrhnchum M. Bieb. (Geraniaceae),
Glycyrrhiza glabra L. (Fabaceae) and
Ferula oopoda (Boiss and Bushe) Boiss. (Apiaceae) were found to have significant antiplasmodial activity (IC
50 ranging from 4.7 to 26.6
μg/ml). These findings lend support to the use of
Buxus hyrcana and
Glycyrrhiza glabra in traditional medicine. The chloroformic fraction also was active against K1 and 3D7 strains. The chloroformic fraction was studied at 10
mg per kg body weight mouse per day. This fraction reduced parasitaemia by 86.1% compared to untreated control mice.
Glycyrrhiza glabra showed antiplasmodial activity and has selectivity for
Plasmodium falciparum and
Plasmodium berghei when tested on mammalian cells. This is the first report that mentioned
in vitro and
in vivo antiplasmodial activity of
Glycyrrhiza glabra.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2008.10.041</identifier><identifier>PMID: 19059470</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; antimalarials ; Antimalarials - pharmacology ; Antimalarials - therapeutic use ; Antineoplastic Agents, Phytogenic - pharmacology ; Antineoplastic Agents, Phytogenic - therapeutic use ; antiprotozoal agents ; Apiaceae ; Breast Neoplasms - drug therapy ; Buxaceae ; Buxus ; Buxus sempervirens ; Cell Line, Tumor ; chloroform ; Cytotoxicity ; Erodium ; Erodium oxyrrhnchum ; Fabaceae ; Female ; Ferula ; Ferula oopoda ; Geraniaceae ; Glycyrrhiza ; Glycyrrhiza glabra ; human cell lines ; human diseases ; Humans ; In vitro antiplasmodial activity ; in vitro studies ; In vivo antimalarial activity ; in vivo studies ; infectious diseases ; inhibitory concentration 50 ; interviews ; Iran ; literature reviews ; Magnoliopsida ; malaria ; Malaria - drug therapy ; Male ; medicinal plants ; medicinal properties ; methanol ; Mice ; neoplasms ; Parasitic Sensitivity Tests ; plant extracts ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plasmodium berghei ; Plasmodium berghei - drug effects ; Plasmodium falciparum ; Plasmodium falciparum - drug effects ; screening ; traditional medicine</subject><ispartof>Journal of ethnopharmacology, 2009-01, Vol.121 (3), p.400-404</ispartof><rights>2008 Elsevier Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-c0213e52965206b6a300f17a4896a86eb3f5d54e0e1e47b5836734a280e435773</citedby><cites>FETCH-LOGICAL-c406t-c0213e52965206b6a300f17a4896a86eb3f5d54e0e1e47b5836734a280e435773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2008.10.041$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19059470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Esmaeili, Somayeh</creatorcontrib><creatorcontrib>Naghibi, Farzaneh</creatorcontrib><creatorcontrib>Mosaddegh, Mahmoud</creatorcontrib><creatorcontrib>Sahranavard, Shamim</creatorcontrib><creatorcontrib>Ghafari, Saeideh</creatorcontrib><creatorcontrib>Abdullah, Noor Rain</creatorcontrib><title>Screening of antiplasmodial properties among some traditionally used Iranian plants</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>An investigation of plants was undertaken through interviews and literature surveys on plants used to treat malaria or cancer or microbial diseases in Iran.
In vitro and
in vivo antiplasmodial tests were carried out on selected plants traditionally used in Iran.
Thirty-two plants were extracted with methanol and tested for their
in vitro (pLDH assay) activity against
Plasmodium falciparum,
in vivo activity against
Plasmodium berghei and assessed for any cytotoxicity against the human cancer cell line MCF7 and the normal cell MDBK.
Extracts from four plants,
Buxus hyrcana Pojark. (Buxaceae),
Erodium oxyrrhnchum M. Bieb. (Geraniaceae),
Glycyrrhiza glabra L. (Fabaceae) and
Ferula oopoda (Boiss and Bushe) Boiss. (Apiaceae) were found to have significant antiplasmodial activity (IC
50 ranging from 4.7 to 26.6
μg/ml). These findings lend support to the use of
Buxus hyrcana and
Glycyrrhiza glabra in traditional medicine. The chloroformic fraction also was active against K1 and 3D7 strains. The chloroformic fraction was studied at 10
mg per kg body weight mouse per day. This fraction reduced parasitaemia by 86.1% compared to untreated control mice.
Glycyrrhiza glabra showed antiplasmodial activity and has selectivity for
Plasmodium falciparum and
Plasmodium berghei when tested on mammalian cells. This is the first report that mentioned
in vitro and
in vivo antiplasmodial activity of
Glycyrrhiza glabra.</description><subject>Animals</subject><subject>antimalarials</subject><subject>Antimalarials - pharmacology</subject><subject>Antimalarials - therapeutic use</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - therapeutic use</subject><subject>antiprotozoal agents</subject><subject>Apiaceae</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Buxaceae</subject><subject>Buxus</subject><subject>Buxus sempervirens</subject><subject>Cell Line, Tumor</subject><subject>chloroform</subject><subject>Cytotoxicity</subject><subject>Erodium</subject><subject>Erodium oxyrrhnchum</subject><subject>Fabaceae</subject><subject>Female</subject><subject>Ferula</subject><subject>Ferula oopoda</subject><subject>Geraniaceae</subject><subject>Glycyrrhiza</subject><subject>Glycyrrhiza glabra</subject><subject>human cell lines</subject><subject>human diseases</subject><subject>Humans</subject><subject>In vitro antiplasmodial activity</subject><subject>in vitro studies</subject><subject>In vivo antimalarial activity</subject><subject>in vivo studies</subject><subject>infectious diseases</subject><subject>inhibitory concentration 50</subject><subject>interviews</subject><subject>Iran</subject><subject>literature reviews</subject><subject>Magnoliopsida</subject><subject>malaria</subject><subject>Malaria - drug therapy</subject><subject>Male</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>methanol</subject><subject>Mice</subject><subject>neoplasms</subject><subject>Parasitic Sensitivity Tests</subject><subject>plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plasmodium berghei</subject><subject>Plasmodium berghei - drug effects</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - drug effects</subject><subject>screening</subject><subject>traditional medicine</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRtH78AC-ak7fU2exn8CTFj0LBQ_W8bJOJbEmycTcV-u_d0oI3PQ0zPO_w8hByTWFKgcr79XSNw7QA0GmfAqdHZEK1KnIlFDsmE2BK51pxekbOY1wDgKIcTskZLUGUXMGELJdVQOxd_5n5JrP96IbWxs7XzrbZEPyAYXQYM9v5hETfYTYGW7vR-d627TbbRKyzebC9s32Wsv0YL8lJY9uIV4d5QT6en95nr_ni7WU-e1zkFQc55hUUlKEoSikKkCtpGUBDleW6lFZLXLFG1IIjIEWuVkIzqRi3hQbkTCjFLsjd_m_q-bXBOJrOxQrbVAL9JhopNWgmyn_BAphWIGQC6R6sgo8xYGOG4DobtoaC2Sk3a5OUm53y3SkpT5mbw_PNqsP6N3FwnIDbPdBYb-xncNF8LAugDKjQlGmWiIc9gcnWt8NgYuWwr7B2AavR1N79UeAHpCSaFA</recordid><startdate>20090130</startdate><enddate>20090130</enddate><creator>Esmaeili, Somayeh</creator><creator>Naghibi, Farzaneh</creator><creator>Mosaddegh, Mahmoud</creator><creator>Sahranavard, Shamim</creator><creator>Ghafari, Saeideh</creator><creator>Abdullah, Noor Rain</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; 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In vitro and
in vivo antiplasmodial tests were carried out on selected plants traditionally used in Iran.
Thirty-two plants were extracted with methanol and tested for their
in vitro (pLDH assay) activity against
Plasmodium falciparum,
in vivo activity against
Plasmodium berghei and assessed for any cytotoxicity against the human cancer cell line MCF7 and the normal cell MDBK.
Extracts from four plants,
Buxus hyrcana Pojark. (Buxaceae),
Erodium oxyrrhnchum M. Bieb. (Geraniaceae),
Glycyrrhiza glabra L. (Fabaceae) and
Ferula oopoda (Boiss and Bushe) Boiss. (Apiaceae) were found to have significant antiplasmodial activity (IC
50 ranging from 4.7 to 26.6
μg/ml). These findings lend support to the use of
Buxus hyrcana and
Glycyrrhiza glabra in traditional medicine. The chloroformic fraction also was active against K1 and 3D7 strains. The chloroformic fraction was studied at 10
mg per kg body weight mouse per day. This fraction reduced parasitaemia by 86.1% compared to untreated control mice.
Glycyrrhiza glabra showed antiplasmodial activity and has selectivity for
Plasmodium falciparum and
Plasmodium berghei when tested on mammalian cells. This is the first report that mentioned
in vitro and
in vivo antiplasmodial activity of
Glycyrrhiza glabra.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>19059470</pmid><doi>10.1016/j.jep.2008.10.041</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2009-01, Vol.121 (3), p.400-404 |
| issn | 0378-8741 1872-7573 |
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| subjects | Animals antimalarials Antimalarials - pharmacology Antimalarials - therapeutic use Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use antiprotozoal agents Apiaceae Breast Neoplasms - drug therapy Buxaceae Buxus Buxus sempervirens Cell Line, Tumor chloroform Cytotoxicity Erodium Erodium oxyrrhnchum Fabaceae Female Ferula Ferula oopoda Geraniaceae Glycyrrhiza Glycyrrhiza glabra human cell lines human diseases Humans In vitro antiplasmodial activity in vitro studies In vivo antimalarial activity in vivo studies infectious diseases inhibitory concentration 50 interviews Iran literature reviews Magnoliopsida malaria Malaria - drug therapy Male medicinal plants medicinal properties methanol Mice neoplasms Parasitic Sensitivity Tests plant extracts Plant Extracts - pharmacology Plant Extracts - therapeutic use Plasmodium berghei Plasmodium berghei - drug effects Plasmodium falciparum Plasmodium falciparum - drug effects screening traditional medicine |
| title | Screening of antiplasmodial properties among some traditionally used Iranian plants |
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