Evaluation of analgesic and anti-inflammatory activities of Nectandra megapotamica (Lauraceae) in mice and rats
The bioactivity‐guided phytochemical investigation of the crude hydralcoholic extract of Nectandra megapotamica was carried out using the abdominal constriction test in mice, which led to the isolation of three active compounds: α‐asarone (1), galgravin (2) and veraguensin (3). The crude extract (EB...
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| Veröffentlicht in: | Journal of pharmacy and pharmacology 2004-09, Vol.56 (9), p.1179-1184 |
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| creator | Filho, Ademar A. da Silva Silva, Márcio L. Andrade e Carvalho, José Carlos T. Bastos, Jairo K. |
| description | The bioactivity‐guided phytochemical investigation of the crude hydralcoholic extract of Nectandra megapotamica was carried out using the abdominal constriction test in mice, which led to the isolation of three active compounds: α‐asarone (1), galgravin (2) and veraguensin (3). The crude extract (EBCA, 300 mg kg−1) and isolated compounds 1, 2, and 3, at different doses, were evaluated using the acetic acid‐induced abdominal constriction test in mice, carrageenan‐induced paw oedema in rats, and hot plate tests in rats. The EBCA showed a significant effect in the abdominal constriction and hot plate tests, but did not show activity in the rat paw oedema assay. All isolated compounds displayed activity in the abdominal constriction test, but only compound 1 was active in the hot plate test. Compounds 2 and 3 displayed activity in the anti‐inflammatory assay. It was suggested that the analgesic effects obtained for EBCA could be due mainly to the presence of its major compound, α‐asarone (1). |
| doi_str_mv | 10.1211/0022357044058 |
| format | Article |
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All isolated compounds displayed activity in the abdominal constriction test, but only compound 1 was active in the hot plate test. Compounds 2 and 3 displayed activity in the anti‐inflammatory assay. 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Andrade e</creatorcontrib><creatorcontrib>Carvalho, José Carlos T.</creatorcontrib><creatorcontrib>Bastos, Jairo K.</creatorcontrib><title>Evaluation of analgesic and anti-inflammatory activities of Nectandra megapotamica (Lauraceae) in mice and rats</title><title>Journal of pharmacy and pharmacology</title><addtitle>J Pharm Pharmacol</addtitle><description>The bioactivity‐guided phytochemical investigation of the crude hydralcoholic extract of Nectandra megapotamica was carried out using the abdominal constriction test in mice, which led to the isolation of three active compounds: α‐asarone (1), galgravin (2) and veraguensin (3). The crude extract (EBCA, 300 mg kg−1) and isolated compounds 1, 2, and 3, at different doses, were evaluated using the acetic acid‐induced abdominal constriction test in mice, carrageenan‐induced paw oedema in rats, and hot plate tests in rats. The EBCA showed a significant effect in the abdominal constriction and hot plate tests, but did not show activity in the rat paw oedema assay. All isolated compounds displayed activity in the abdominal constriction test, but only compound 1 was active in the hot plate test. Compounds 2 and 3 displayed activity in the anti‐inflammatory assay. 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Andrade e</creator><creator>Carvalho, José Carlos T.</creator><creator>Bastos, Jairo K.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200409</creationdate><title>Evaluation of analgesic and anti-inflammatory activities of Nectandra megapotamica (Lauraceae) in mice and rats</title><author>Filho, Ademar A. da Silva ; Silva, Márcio L. Andrade e ; Carvalho, José Carlos T. ; Bastos, Jairo K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4763-dc585c24d6c14fc77db213c5f6c8bcf71d5f8dc6d926bfac5d91e6a75f98a85c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Analgesics - chemistry</topic><topic>Analgesics - isolation & purification</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - isolation & purification</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Evaluation, Preclinical - methods</topic><topic>Lauraceae</topic><topic>Male</topic><topic>Mice</topic><topic>Pain Measurement - drug effects</topic><topic>Pain Measurement - methods</topic><topic>Plant Bark</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Filho, Ademar A. da Silva</creatorcontrib><creatorcontrib>Silva, Márcio L. 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Andrade e</au><au>Carvalho, José Carlos T.</au><au>Bastos, Jairo K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of analgesic and anti-inflammatory activities of Nectandra megapotamica (Lauraceae) in mice and rats</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2004-09</date><risdate>2004</risdate><volume>56</volume><issue>9</issue><spage>1179</spage><epage>1184</epage><pages>1179-1184</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><abstract>The bioactivity‐guided phytochemical investigation of the crude hydralcoholic extract of Nectandra megapotamica was carried out using the abdominal constriction test in mice, which led to the isolation of three active compounds: α‐asarone (1), galgravin (2) and veraguensin (3). The crude extract (EBCA, 300 mg kg−1) and isolated compounds 1, 2, and 3, at different doses, were evaluated using the acetic acid‐induced abdominal constriction test in mice, carrageenan‐induced paw oedema in rats, and hot plate tests in rats. The EBCA showed a significant effect in the abdominal constriction and hot plate tests, but did not show activity in the rat paw oedema assay. All isolated compounds displayed activity in the abdominal constriction test, but only compound 1 was active in the hot plate test. Compounds 2 and 3 displayed activity in the anti‐inflammatory assay. It was suggested that the analgesic effects obtained for EBCA could be due mainly to the presence of its major compound, α‐asarone (1).</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15324487</pmid><doi>10.1211/0022357044058</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Analgesics - chemistry Analgesics - isolation & purification Analgesics - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - pharmacology Dose-Response Relationship, Drug Drug Evaluation, Preclinical - methods Lauraceae Male Mice Pain Measurement - drug effects Pain Measurement - methods Plant Bark Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Rats Rats, Wistar |
| title | Evaluation of analgesic and anti-inflammatory activities of Nectandra megapotamica (Lauraceae) in mice and rats |
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