Glutathione S-transferase M1 and T1 null genotype distribution in South Indians
To investigate the distribution of the homozygous null genotypes of GSTM1 and GSTT1 in the South Indian population. Five hundred and seventeen unrelated natives of the South Indian states of Tamilnadu and Pondicherry (n=170), Kerala (n=122), Karnataka (n=110) and Andhra Pradesh (n=115) were analyzed...
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| Veröffentlicht in: | European journal of clinical pharmacology 2004-08, Vol.60 (6), p.403-406 |
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| creator | NAVEEN, A. T ADITHAN, C PADMAJA, N SHASHINDRAN, C. H ABRAHAM, B. K SATYANARAYANAMOORTHY, K ANITHA, P GERARD, N KRISHNAMOORTHY, R |
| description | To investigate the distribution of the homozygous null genotypes of GSTM1 and GSTT1 in the South Indian population.
Five hundred and seventeen unrelated natives of the South Indian states of Tamilnadu and Pondicherry (n=170), Kerala (n=122), Karnataka (n=110) and Andhra Pradesh (n=115) were analyzed for homozygous deletions of GSTM1 and GSTT1. A multiplex polymerase chain reaction method simultaneously detected both GSTM1 and GSTT1 homozygous null genotypes. The observed frequencies from the four groups were compared statistically with each other and the combined frequencies were compared with frequencies of other major populations previously reported in the literature.
In South India, 30.4% (95% CI 26.4-34.3) lacked the GSTM1 gene, 16.8% (13.6-20.1) lacked the GSTT1 gene and 4.6% (3.0-6.8) lacked both the GSTM1 and GSTT1 genes. The highest frequency of GSTM1 null was observed in Karnataka (36.4%, 27.4-45.4), while Andhra Pradesh had the lowest frequency of the GSTM1 and GSTT1 combined double-null genotypes (1.7%, 0.21-6.2).
The prevalence of the GSTM1 null genotype differed within India. The frequency of GSTM1 null in South Indians was significantly lower than that in Caucasians. The frequencies of both GSTM1 and GSTT1 null genotypes in South Indians were significantly lower than in the Japanese. |
| doi_str_mv | 10.1007/s00228-004-0779-3 |
| format | Article |
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Five hundred and seventeen unrelated natives of the South Indian states of Tamilnadu and Pondicherry (n=170), Kerala (n=122), Karnataka (n=110) and Andhra Pradesh (n=115) were analyzed for homozygous deletions of GSTM1 and GSTT1. A multiplex polymerase chain reaction method simultaneously detected both GSTM1 and GSTT1 homozygous null genotypes. The observed frequencies from the four groups were compared statistically with each other and the combined frequencies were compared with frequencies of other major populations previously reported in the literature.
In South India, 30.4% (95% CI 26.4-34.3) lacked the GSTM1 gene, 16.8% (13.6-20.1) lacked the GSTT1 gene and 4.6% (3.0-6.8) lacked both the GSTM1 and GSTT1 genes. The highest frequency of GSTM1 null was observed in Karnataka (36.4%, 27.4-45.4), while Andhra Pradesh had the lowest frequency of the GSTM1 and GSTT1 combined double-null genotypes (1.7%, 0.21-6.2).
The prevalence of the GSTM1 null genotype differed within India. The frequency of GSTM1 null in South Indians was significantly lower than that in Caucasians. The frequencies of both GSTM1 and GSTT1 null genotypes in South Indians were significantly lower than in the Japanese.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/s00228-004-0779-3</identifier><identifier>PMID: 15197518</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Biological and medical sciences ; Female ; Gene Deletion ; Gene Frequency ; Genotype ; Glutathione Transferase - genetics ; Humans ; India - epidemiology ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Reverse Transcriptase Polymerase Chain Reaction</subject><ispartof>European journal of clinical pharmacology, 2004-08, Vol.60 (6), p.403-406</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Springer-Verlag 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-a6e28350dd412539d5b03d044c8326b5e9980c433ec574737922e096ccd94f783</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16065134$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15197518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAVEEN, A. T</creatorcontrib><creatorcontrib>ADITHAN, C</creatorcontrib><creatorcontrib>PADMAJA, N</creatorcontrib><creatorcontrib>SHASHINDRAN, C. H</creatorcontrib><creatorcontrib>ABRAHAM, B. K</creatorcontrib><creatorcontrib>SATYANARAYANAMOORTHY, K</creatorcontrib><creatorcontrib>ANITHA, P</creatorcontrib><creatorcontrib>GERARD, N</creatorcontrib><creatorcontrib>KRISHNAMOORTHY, R</creatorcontrib><title>Glutathione S-transferase M1 and T1 null genotype distribution in South Indians</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>To investigate the distribution of the homozygous null genotypes of GSTM1 and GSTT1 in the South Indian population.
Five hundred and seventeen unrelated natives of the South Indian states of Tamilnadu and Pondicherry (n=170), Kerala (n=122), Karnataka (n=110) and Andhra Pradesh (n=115) were analyzed for homozygous deletions of GSTM1 and GSTT1. A multiplex polymerase chain reaction method simultaneously detected both GSTM1 and GSTT1 homozygous null genotypes. The observed frequencies from the four groups were compared statistically with each other and the combined frequencies were compared with frequencies of other major populations previously reported in the literature.
In South India, 30.4% (95% CI 26.4-34.3) lacked the GSTM1 gene, 16.8% (13.6-20.1) lacked the GSTT1 gene and 4.6% (3.0-6.8) lacked both the GSTM1 and GSTT1 genes. The highest frequency of GSTM1 null was observed in Karnataka (36.4%, 27.4-45.4), while Andhra Pradesh had the lowest frequency of the GSTM1 and GSTT1 combined double-null genotypes (1.7%, 0.21-6.2).
The prevalence of the GSTM1 null genotype differed within India. The frequency of GSTM1 null in South Indians was significantly lower than that in Caucasians. The frequencies of both GSTM1 and GSTT1 null genotypes in South Indians were significantly lower than in the Japanese.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Gene Deletion</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. 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T</au><au>ADITHAN, C</au><au>PADMAJA, N</au><au>SHASHINDRAN, C. H</au><au>ABRAHAM, B. K</au><au>SATYANARAYANAMOORTHY, K</au><au>ANITHA, P</au><au>GERARD, N</au><au>KRISHNAMOORTHY, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione S-transferase M1 and T1 null genotype distribution in South Indians</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>2004-08-01</date><risdate>2004</risdate><volume>60</volume><issue>6</issue><spage>403</spage><epage>406</epage><pages>403-406</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>To investigate the distribution of the homozygous null genotypes of GSTM1 and GSTT1 in the South Indian population.
Five hundred and seventeen unrelated natives of the South Indian states of Tamilnadu and Pondicherry (n=170), Kerala (n=122), Karnataka (n=110) and Andhra Pradesh (n=115) were analyzed for homozygous deletions of GSTM1 and GSTT1. A multiplex polymerase chain reaction method simultaneously detected both GSTM1 and GSTT1 homozygous null genotypes. The observed frequencies from the four groups were compared statistically with each other and the combined frequencies were compared with frequencies of other major populations previously reported in the literature.
In South India, 30.4% (95% CI 26.4-34.3) lacked the GSTM1 gene, 16.8% (13.6-20.1) lacked the GSTT1 gene and 4.6% (3.0-6.8) lacked both the GSTM1 and GSTT1 genes. The highest frequency of GSTM1 null was observed in Karnataka (36.4%, 27.4-45.4), while Andhra Pradesh had the lowest frequency of the GSTM1 and GSTT1 combined double-null genotypes (1.7%, 0.21-6.2).
The prevalence of the GSTM1 null genotype differed within India. The frequency of GSTM1 null in South Indians was significantly lower than that in Caucasians. The frequencies of both GSTM1 and GSTT1 null genotypes in South Indians were significantly lower than in the Japanese.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>15197518</pmid><doi>10.1007/s00228-004-0779-3</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Female Gene Deletion Gene Frequency Genotype Glutathione Transferase - genetics Humans India - epidemiology Male Medical sciences Pharmacology. Drug treatments Reverse Transcriptase Polymerase Chain Reaction |
| title | Glutathione S-transferase M1 and T1 null genotype distribution in South Indians |
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