Structural and Biochemical Characterization of the Wild Type PCSK9-EGF(AB) Complex and Natural Familial Hypercholesterolemia Mutants

PCSK9 regulates low density lipoprotein receptor (LDLR) levels and consequently is a target for the prevention of atherosclerosis and coronary heart disease. Here we studied the interaction, of LDLR EGF(A/AB) repeats with PCSK9. We show that PCSK9 binds the EGF(AB) repeats in a pH-dependent manner....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2009-01, Vol.284 (2), p.1313-1323
Hauptverfasser:	Bottomley, Matthew J., Cirillo, Agostino, Orsatti, Laura, Ruggeri, Lionello, Fisher, Timothy S., Santoro, Joseph C., Cummings, Richard T., Cubbon, Rose M., Lo Surdo, Paola, Calzetta, Alessandra, Noto, Alessia, Baysarowich, Jennifer, Mattu, Marco, Talamo, Fabio, De Francesco, Raffaele, Sparrow, Carl P., Sitlani, Ayesha, Carfí, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cell Line Crystallography, X-Ray Humans Hyperlipoproteinemia Type II Models, Molecular Molecular Sequence Data Mutation - genetics Proprotein Convertase 9 Proprotein Convertases Protein Binding Protein Structure, Quaternary Protein Structure, Tertiary Receptors, LDL - metabolism Serine Endopeptidases - chemistry Serine Endopeptidases - genetics Serine Endopeptidases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!