Effect of YM928, a novel AMPA receptor antagonist, on seizures in EL mice and kainate-induced seizures in rats

Kainate-induced seizures and seizures induced by tossing stimulation in epilepsy-prone EL mice are considered as models of complex partial seizures. We used these models to evaluate the anticonvulsive effects of 2-[ N-(4-chlorophenyl)- N-methylamino]-4 H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), a no...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2004-08, Vol.370 (2), p.99-105
Hauptverfasser:	Yamashita, Hiroshi, Ohno, Kazushige, Amada, Yoko, Inami, Hiroshi, Shishikura, Jun-Ichi, Sakamoto, Shuichi, Okada, Masamichi, Yamaguchi, Tokio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - administration & dosage Anticonvulsants - therapeutic use Dose-Response Relationship, Drug Epilepsies, Partial - drug therapy Epilepsies, Partial - etiology Handling (Psychology) Kainic Acid Male Mice Pyridines Rats Rats, Wistar Receptors, AMPA - antagonists & inhibitors Thiazines - administration & dosage Thiazines - therapeutic use Time Factors
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