Vascular Endothelium Does Not Activate CD4+ Direct Allorecognition in Graft Rejection

Expression of MHC class II by donor-derived APCs has been shown to be important for allograft rejection. It remains controversial, however, whether nonhemopoietic cells, such as vascular endothelium, possess Ag-presenting capacity to activate alloreactive CD4(+) T lymphocytes. This issue is importan...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-09, Vol.173 (5), p.3027-3034
Hauptverfasser:	Kreisel, Daniel, Krasinskas, Alyssa M, Krupnick, Alexander S, Gelman, Andrew E, Balsara, Keki R, Popma, Sicco H, Riha, Markus, Rosengard, Ariella M, Turka, Laurence A, Rosengard, Bruce R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Presenting Cells - immunology CD4 Antigens - immunology Endothelium, Vascular - immunology Graft Rejection - immunology Heart Transplantation - immunology Histocompatibility Antigens Class II - immunology In Vitro Techniques Male Mice Mice, Inbred C57BL
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