Ligand- and species-dependent activation of PPARalpha

Peroxisome proliferator-activated receptor alpha (PPARalpha) is mainly expressed in liver and involved in lipid metabolism. Oxidation of certain fatty acids in peroxisomes is under PPARalpha control. A wide variety of lipid molecules activate PPARalpha as well as the fibric acid derivative clofibrat...

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Veröffentlicht in:	Cellular physiology and biochemistry 2004, Vol.14 (4-6), p.269-276
Hauptverfasser:	Akbiyik, Filiz, Ray, Denise M, Bozkaya, Hakan, Demirpence, Ediz
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Hepatocellular - metabolism Cell Line, Tumor Cell Survival Clofibrate - pharmacology DNA - metabolism Electrophoretic Mobility Shift Assay Fatty Acids, Unsaturated - metabolism Fatty Acids, Unsaturated - pharmacology Fatty Acids, Unsaturated - physiology Humans Ligands Linoleic Acid - pharmacology Linoleic Acid - physiology Liver - metabolism PPAR alpha - agonists PPAR alpha - analysis PPAR alpha - physiology Rats Species Specificity
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