Influence of Leukotriene Inhibitor Montelukast on Wound Contraction and Cutaneous Healing Process in Rats
Background Wound contractures can cause severe deformities and disabilities. Recent studies have suggested that leukotriene receptor antagonists have an inhibitory effect on the healing contraction process. This study aimed to evaluate the influence of the leukotriene inhibitor montelukast on the cu...
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| Veröffentlicht in: | Aesthetic plastic surgery 2009, Vol.33 (1), p.84-89 |
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| creator | Tolazzi, Andre Ricardo D. Tolazzi, Karine D. Garcia, Mariana Graf, Ruth M. Freitas, Renato S. Baretta, Giorgio A. P. Matias, Jorge E. F. Campos, Antônio C. L. |
| description | Background
Wound contractures can cause severe deformities and disabilities. Recent studies have suggested that leukotriene receptor antagonists have an inhibitory effect on the healing contraction process. This study aimed to evaluate the influence of the leukotriene inhibitor montelukast on the cutaneous healing process and the wound contraction phenomenon in rats.
Methods
For this study, 60 male rats were randomly divided into four groups (MK-7d, SF-7d, MK-14d, and SF-14d) according to the drug given through a rigid orogastric tube (MK group: montelukast 10 mg/kg/day; SF group: normal saline solution) and the day the animals were killed (7d: postoperative day 7; 14d: postoperative day 14). An excisional wound (2 × 2 cm) was created on the dorsum of each rat. The wounds were left open to heal spontaneously and documented by standard digital photographs on different postoperative days. Wound contraction rates were calculated with specific software, and specimens were histologically evaluated using picrosirius red stain. Results were analyzed using the Aspin-Welch, Mann–Whitney, and
t
tests, assuming a significance level of 5%.
Results
The wound contraction rates were similar between the control and study groups (
p
> 0.05). On postoperative day 7, the wounds showed a marginally significant reduction in collagen maturation in the study group (40.1% ± 6.88% vs 61.2% ± 8.02%;
p
= 0.0607). On postoperative day 14, this reduction was statistically significant in the MK group (26% ± 5.66% vs 68.3% ± 7.76%;
p
= 0.0001).
Conclusions
Montelukast does not alter the contraction rate of excisional wounds in rats but has a significant and progressive inhibitory effect on collagen maturation. |
| doi_str_mv | 10.1007/s00266-008-9241-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66804431</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1894988971</sourcerecordid><originalsourceid>FETCH-LOGICAL-c369t-79325b46a97dd95abeac365eea773af8037611579a7862319d20ef60b651a5433</originalsourceid><addsrcrecordid>eNp1kU1rHDEMhk1oSLZpf0AvxfSQ27T-Gnt8LEs-FrY0hIT2ZjwzmtTJrJ3645B_Hy-zECj0JCQ9eiX0IvSJkq-UEPUtEcKkbAjpGs0EbbojtKKCs6at2Tu0IlyKhlH5-xS9T-mREMqUEifolHZKK93qFXIbP80F_AA4THgL5Snk6MAD3vg_rnc5RPwj-AxzebIp4-Dxr1D8iNe1GO2QXa3YfV6y9RBKwtdgZ-cf8E0MA6SEnce3NqcP6Hiyc4KPh3iG7i8v7tbXzfbn1Wb9fdsMXOrcKM1Z2wtptRpH3doebG20AFYpbqeOcCUpbZW2qpOMUz0yApMkvWypbQXnZ-h80X2O4W-BlM3OpQHmeTnPSNkRITit4Jd_wMdQoq-3GUaUFETxvRpdoCGGlCJM5jm6nY0vhhKzN8EsJphqgtmbYLo68_kgXPodjG8Th69XgC1Aqi3_APFt8_9VXwFTc5HX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>207640733</pqid></control><display><type>article</type><title>Influence of Leukotriene Inhibitor Montelukast on Wound Contraction and Cutaneous Healing Process in Rats</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Tolazzi, Andre Ricardo D. ; Tolazzi, Karine D. ; Garcia, Mariana ; Graf, Ruth M. ; Freitas, Renato S. ; Baretta, Giorgio A. P. ; Matias, Jorge E. F. ; Campos, Antônio C. L.</creator><creatorcontrib>Tolazzi, Andre Ricardo D. ; Tolazzi, Karine D. ; Garcia, Mariana ; Graf, Ruth M. ; Freitas, Renato S. ; Baretta, Giorgio A. P. ; Matias, Jorge E. F. ; Campos, Antônio C. L.</creatorcontrib><description>Background
Wound contractures can cause severe deformities and disabilities. Recent studies have suggested that leukotriene receptor antagonists have an inhibitory effect on the healing contraction process. This study aimed to evaluate the influence of the leukotriene inhibitor montelukast on the cutaneous healing process and the wound contraction phenomenon in rats.
Methods
For this study, 60 male rats were randomly divided into four groups (MK-7d, SF-7d, MK-14d, and SF-14d) according to the drug given through a rigid orogastric tube (MK group: montelukast 10 mg/kg/day; SF group: normal saline solution) and the day the animals were killed (7d: postoperative day 7; 14d: postoperative day 14). An excisional wound (2 × 2 cm) was created on the dorsum of each rat. The wounds were left open to heal spontaneously and documented by standard digital photographs on different postoperative days. Wound contraction rates were calculated with specific software, and specimens were histologically evaluated using picrosirius red stain. Results were analyzed using the Aspin-Welch, Mann–Whitney, and
t
tests, assuming a significance level of 5%.
Results
The wound contraction rates were similar between the control and study groups (
p
> 0.05). On postoperative day 7, the wounds showed a marginally significant reduction in collagen maturation in the study group (40.1% ± 6.88% vs 61.2% ± 8.02%;
p
= 0.0607). On postoperative day 14, this reduction was statistically significant in the MK group (26% ± 5.66% vs 68.3% ± 7.76%;
p
= 0.0001).
Conclusions
Montelukast does not alter the contraction rate of excisional wounds in rats but has a significant and progressive inhibitory effect on collagen maturation.</description><identifier>ISSN: 0364-216X</identifier><identifier>EISSN: 1432-5241</identifier><identifier>DOI: 10.1007/s00266-008-9241-8</identifier><identifier>PMID: 18797959</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Acetates - administration & dosage ; Animals ; Collagen - drug effects ; Collagen - metabolism ; Dermatologic Surgical Procedures ; Disease Models, Animal ; Leukotriene Antagonists - administration & dosage ; Male ; Medicine ; Medicine & Public Health ; Original Article ; Otorhinolaryngology ; Plastic Surgery ; Probability ; Quinolines - administration & dosage ; Random Allocation ; Rats ; Rats, Wistar ; Reference Values ; Sensitivity and Specificity ; Skin - injuries ; Statistics, Nonparametric ; Wound Healing - drug effects</subject><ispartof>Aesthetic plastic surgery, 2009, Vol.33 (1), p.84-89</ispartof><rights>Springer Science+Business Media, LLC and International Society of Aesthetic Plastic Surgery 2008</rights><rights>Springer Science+Business Media, LLC and International Society of Aesthetic Plastic Surgery 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-79325b46a97dd95abeac365eea773af8037611579a7862319d20ef60b651a5433</citedby><cites>FETCH-LOGICAL-c369t-79325b46a97dd95abeac365eea773af8037611579a7862319d20ef60b651a5433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00266-008-9241-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00266-008-9241-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18797959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tolazzi, Andre Ricardo D.</creatorcontrib><creatorcontrib>Tolazzi, Karine D.</creatorcontrib><creatorcontrib>Garcia, Mariana</creatorcontrib><creatorcontrib>Graf, Ruth M.</creatorcontrib><creatorcontrib>Freitas, Renato S.</creatorcontrib><creatorcontrib>Baretta, Giorgio A. P.</creatorcontrib><creatorcontrib>Matias, Jorge E. F.</creatorcontrib><creatorcontrib>Campos, Antônio C. L.</creatorcontrib><title>Influence of Leukotriene Inhibitor Montelukast on Wound Contraction and Cutaneous Healing Process in Rats</title><title>Aesthetic plastic surgery</title><addtitle>Aesth Plast Surg</addtitle><addtitle>Aesthetic Plast Surg</addtitle><description>Background
Wound contractures can cause severe deformities and disabilities. Recent studies have suggested that leukotriene receptor antagonists have an inhibitory effect on the healing contraction process. This study aimed to evaluate the influence of the leukotriene inhibitor montelukast on the cutaneous healing process and the wound contraction phenomenon in rats.
Methods
For this study, 60 male rats were randomly divided into four groups (MK-7d, SF-7d, MK-14d, and SF-14d) according to the drug given through a rigid orogastric tube (MK group: montelukast 10 mg/kg/day; SF group: normal saline solution) and the day the animals were killed (7d: postoperative day 7; 14d: postoperative day 14). An excisional wound (2 × 2 cm) was created on the dorsum of each rat. The wounds were left open to heal spontaneously and documented by standard digital photographs on different postoperative days. Wound contraction rates were calculated with specific software, and specimens were histologically evaluated using picrosirius red stain. Results were analyzed using the Aspin-Welch, Mann–Whitney, and
t
tests, assuming a significance level of 5%.
Results
The wound contraction rates were similar between the control and study groups (
p
> 0.05). On postoperative day 7, the wounds showed a marginally significant reduction in collagen maturation in the study group (40.1% ± 6.88% vs 61.2% ± 8.02%;
p
= 0.0607). On postoperative day 14, this reduction was statistically significant in the MK group (26% ± 5.66% vs 68.3% ± 7.76%;
p
= 0.0001).
Conclusions
Montelukast does not alter the contraction rate of excisional wounds in rats but has a significant and progressive inhibitory effect on collagen maturation.</description><subject>Acetates - administration & dosage</subject><subject>Animals</subject><subject>Collagen - drug effects</subject><subject>Collagen - metabolism</subject><subject>Dermatologic Surgical Procedures</subject><subject>Disease Models, Animal</subject><subject>Leukotriene Antagonists - administration & dosage</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Otorhinolaryngology</subject><subject>Plastic Surgery</subject><subject>Probability</subject><subject>Quinolines - administration & dosage</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reference Values</subject><subject>Sensitivity and Specificity</subject><subject>Skin - injuries</subject><subject>Statistics, Nonparametric</subject><subject>Wound Healing - drug effects</subject><issn>0364-216X</issn><issn>1432-5241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1rHDEMhk1oSLZpf0AvxfSQ27T-Gnt8LEs-FrY0hIT2ZjwzmtTJrJ3645B_Hy-zECj0JCQ9eiX0IvSJkq-UEPUtEcKkbAjpGs0EbbojtKKCs6at2Tu0IlyKhlH5-xS9T-mREMqUEifolHZKK93qFXIbP80F_AA4THgL5Snk6MAD3vg_rnc5RPwj-AxzebIp4-Dxr1D8iNe1GO2QXa3YfV6y9RBKwtdgZ-cf8E0MA6SEnce3NqcP6Hiyc4KPh3iG7i8v7tbXzfbn1Wb9fdsMXOrcKM1Z2wtptRpH3doebG20AFYpbqeOcCUpbZW2qpOMUz0yApMkvWypbQXnZ-h80X2O4W-BlM3OpQHmeTnPSNkRITit4Jd_wMdQoq-3GUaUFETxvRpdoCGGlCJM5jm6nY0vhhKzN8EsJphqgtmbYLo68_kgXPodjG8Th69XgC1Aqi3_APFt8_9VXwFTc5HX</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Tolazzi, Andre Ricardo D.</creator><creator>Tolazzi, Karine D.</creator><creator>Garcia, Mariana</creator><creator>Graf, Ruth M.</creator><creator>Freitas, Renato S.</creator><creator>Baretta, Giorgio A. P.</creator><creator>Matias, Jorge E. F.</creator><creator>Campos, Antônio C. L.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>2009</creationdate><title>Influence of Leukotriene Inhibitor Montelukast on Wound Contraction and Cutaneous Healing Process in Rats</title><author>Tolazzi, Andre Ricardo D. ; Tolazzi, Karine D. ; Garcia, Mariana ; Graf, Ruth M. ; Freitas, Renato S. ; Baretta, Giorgio A. P. ; Matias, Jorge E. F. ; Campos, Antônio C. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-79325b46a97dd95abeac365eea773af8037611579a7862319d20ef60b651a5433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acetates - administration & dosage</topic><topic>Animals</topic><topic>Collagen - drug effects</topic><topic>Collagen - metabolism</topic><topic>Dermatologic Surgical Procedures</topic><topic>Disease Models, Animal</topic><topic>Leukotriene Antagonists - administration & dosage</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Otorhinolaryngology</topic><topic>Plastic Surgery</topic><topic>Probability</topic><topic>Quinolines - administration & dosage</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reference Values</topic><topic>Sensitivity and Specificity</topic><topic>Skin - injuries</topic><topic>Statistics, Nonparametric</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tolazzi, Andre Ricardo D.</creatorcontrib><creatorcontrib>Tolazzi, Karine D.</creatorcontrib><creatorcontrib>Garcia, Mariana</creatorcontrib><creatorcontrib>Graf, Ruth M.</creatorcontrib><creatorcontrib>Freitas, Renato S.</creatorcontrib><creatorcontrib>Baretta, Giorgio A. P.</creatorcontrib><creatorcontrib>Matias, Jorge E. F.</creatorcontrib><creatorcontrib>Campos, Antônio C. L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Aesthetic plastic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tolazzi, Andre Ricardo D.</au><au>Tolazzi, Karine D.</au><au>Garcia, Mariana</au><au>Graf, Ruth M.</au><au>Freitas, Renato S.</au><au>Baretta, Giorgio A. P.</au><au>Matias, Jorge E. F.</au><au>Campos, Antônio C. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Leukotriene Inhibitor Montelukast on Wound Contraction and Cutaneous Healing Process in Rats</atitle><jtitle>Aesthetic plastic surgery</jtitle><stitle>Aesth Plast Surg</stitle><addtitle>Aesthetic Plast Surg</addtitle><date>2009</date><risdate>2009</risdate><volume>33</volume><issue>1</issue><spage>84</spage><epage>89</epage><pages>84-89</pages><issn>0364-216X</issn><eissn>1432-5241</eissn><abstract>Background
Wound contractures can cause severe deformities and disabilities. Recent studies have suggested that leukotriene receptor antagonists have an inhibitory effect on the healing contraction process. This study aimed to evaluate the influence of the leukotriene inhibitor montelukast on the cutaneous healing process and the wound contraction phenomenon in rats.
Methods
For this study, 60 male rats were randomly divided into four groups (MK-7d, SF-7d, MK-14d, and SF-14d) according to the drug given through a rigid orogastric tube (MK group: montelukast 10 mg/kg/day; SF group: normal saline solution) and the day the animals were killed (7d: postoperative day 7; 14d: postoperative day 14). An excisional wound (2 × 2 cm) was created on the dorsum of each rat. The wounds were left open to heal spontaneously and documented by standard digital photographs on different postoperative days. Wound contraction rates were calculated with specific software, and specimens were histologically evaluated using picrosirius red stain. Results were analyzed using the Aspin-Welch, Mann–Whitney, and
t
tests, assuming a significance level of 5%.
Results
The wound contraction rates were similar between the control and study groups (
p
> 0.05). On postoperative day 7, the wounds showed a marginally significant reduction in collagen maturation in the study group (40.1% ± 6.88% vs 61.2% ± 8.02%;
p
= 0.0607). On postoperative day 14, this reduction was statistically significant in the MK group (26% ± 5.66% vs 68.3% ± 7.76%;
p
= 0.0001).
Conclusions
Montelukast does not alter the contraction rate of excisional wounds in rats but has a significant and progressive inhibitory effect on collagen maturation.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>18797959</pmid><doi>10.1007/s00266-008-9241-8</doi><tpages>6</tpages></addata></record> |
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| subjects | Acetates - administration & dosage Animals Collagen - drug effects Collagen - metabolism Dermatologic Surgical Procedures Disease Models, Animal Leukotriene Antagonists - administration & dosage Male Medicine Medicine & Public Health Original Article Otorhinolaryngology Plastic Surgery Probability Quinolines - administration & dosage Random Allocation Rats Rats, Wistar Reference Values Sensitivity and Specificity Skin - injuries Statistics, Nonparametric Wound Healing - drug effects |
| title | Influence of Leukotriene Inhibitor Montelukast on Wound Contraction and Cutaneous Healing Process in Rats |
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