Preferential transfer of endogenous ovarian steroid hormones to the uterus during both the follicular and luteal phases
BACKGROUND: Ovarian steroids are thought to be released into the systemic circulation and reach the uterus via the uterine arteries. However, results of experimental and clinical studies suggest the existence of local transfer of steroids from the ovary to the uterus. This study aimed to verify the...
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| Veröffentlicht in: | Human reproduction (Oxford) 2004-09, Vol.19 (9), p.2001-2004 |
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| container_title | Human reproduction (Oxford) |
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| creator | Cicinelli, Ettore Einer-Jensen, Niels Cignarelli, Mauro Mangiacotti, Lucia Luisi, Diletta Schonauer, Sergio |
| description | BACKGROUND: Ovarian steroids are thought to be released into the systemic circulation and reach the uterus via the uterine arteries. However, results of experimental and clinical studies suggest the existence of local transfer of steroids from the ovary to the uterus. This study aimed to verify the existence of preferential distribution of ovarian steroids to the uterus in the two phases of the menstrual cycle. METHODS: We performed parallel measurements of serum levels of estradiol and progesterone in the systemic circulation (arterial and venous) and in the uterine vessels in two groups of cycling women; one group were in the follicular phase (six women) and the other group were in the luteal phase (10 women) of the menstrual cycle. RESULTS: Both in the follicular phase and in the luteal phase groups, mean estradiol levels in the uterine blood were significantly higher than in both sides of the systemic circulation (F=7.30, df =15, P |
| doi_str_mv | 10.1093/humrep/deh404 |
| format | Article |
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However, results of experimental and clinical studies suggest the existence of local transfer of steroids from the ovary to the uterus. This study aimed to verify the existence of preferential distribution of ovarian steroids to the uterus in the two phases of the menstrual cycle. METHODS: We performed parallel measurements of serum levels of estradiol and progesterone in the systemic circulation (arterial and venous) and in the uterine vessels in two groups of cycling women; one group were in the follicular phase (six women) and the other group were in the luteal phase (10 women) of the menstrual cycle. RESULTS: Both in the follicular phase and in the luteal phase groups, mean estradiol levels in the uterine blood were significantly higher than in both sides of the systemic circulation (F=7.30, df =15, P<0.006; and F=4.70, df =27, P<0.02). Similar results were obtained in the luteal phase group for progesterone (F=9.38, df =27, P<0.0001). Both estradiol and progesterone levels in arterial and venous systemic blood were similar. CONCLUSIONS: The results of this study demonstrate that ovarian steroid levels are significantly higher in the uterine vessels than in both sides of the systemic blood circulation, and strongly suggest the existence in the female pelvis of mechanisms of local distribution of ovarian hormones.</description><identifier>ISSN: 0268-1161</identifier><identifier>ISSN: 1460-2350</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/deh404</identifier><identifier>PMID: 15243001</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Arteries ; Biological and medical sciences ; blood supply ; Embryology: invertebrates and vertebrates. Teratology ; Estradiol - blood ; Female ; Follicular Phase - blood ; Fundamental and applied biological sciences. Psychology ; Humans ; local transfer ; Luteal Phase - blood ; Middle Aged ; ovarian steroids ; Progesterone - blood ; tube ; uterus ; Uterus - blood supply ; Veins</subject><ispartof>Human reproduction (Oxford), 2004-09, Vol.19 (9), p.2001-2004</ispartof><rights>Human Reproduction vol. 19 no. 9 © European Society of Human Reproduction and Embryology 2004; all rights reserved 2004</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Sep 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-7fa17057228015e60b5fce0b856e95b0741c64575b9d3ea676b504bf091863c63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16098871$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15243001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cicinelli, Ettore</creatorcontrib><creatorcontrib>Einer-Jensen, Niels</creatorcontrib><creatorcontrib>Cignarelli, Mauro</creatorcontrib><creatorcontrib>Mangiacotti, Lucia</creatorcontrib><creatorcontrib>Luisi, Diletta</creatorcontrib><creatorcontrib>Schonauer, Sergio</creatorcontrib><title>Preferential transfer of endogenous ovarian steroid hormones to the uterus during both the follicular and luteal phases</title><title>Human reproduction (Oxford)</title><addtitle>Hum. Reprod</addtitle><addtitle>Hum. Reprod</addtitle><description>BACKGROUND: Ovarian steroids are thought to be released into the systemic circulation and reach the uterus via the uterine arteries. However, results of experimental and clinical studies suggest the existence of local transfer of steroids from the ovary to the uterus. This study aimed to verify the existence of preferential distribution of ovarian steroids to the uterus in the two phases of the menstrual cycle. METHODS: We performed parallel measurements of serum levels of estradiol and progesterone in the systemic circulation (arterial and venous) and in the uterine vessels in two groups of cycling women; one group were in the follicular phase (six women) and the other group were in the luteal phase (10 women) of the menstrual cycle. RESULTS: Both in the follicular phase and in the luteal phase groups, mean estradiol levels in the uterine blood were significantly higher than in both sides of the systemic circulation (F=7.30, df =15, P<0.006; and F=4.70, df =27, P<0.02). Similar results were obtained in the luteal phase group for progesterone (F=9.38, df =27, P<0.0001). Both estradiol and progesterone levels in arterial and venous systemic blood were similar. CONCLUSIONS: The results of this study demonstrate that ovarian steroid levels are significantly higher in the uterine vessels than in both sides of the systemic blood circulation, and strongly suggest the existence in the female pelvis of mechanisms of local distribution of ovarian hormones.</description><subject>Adult</subject><subject>Arteries</subject><subject>Biological and medical sciences</subject><subject>blood supply</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Follicular Phase - blood</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>local transfer</subject><subject>Luteal Phase - blood</subject><subject>Middle Aged</subject><subject>ovarian steroids</subject><subject>Progesterone - blood</subject><subject>tube</subject><subject>uterus</subject><subject>Uterus - blood supply</subject><subject>Veins</subject><issn>0268-1161</issn><issn>1460-2350</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0d9r1zAQAPAgDvd1-uirBEHxpe7SND_6KF_Ur7CxIQriS0jb69rZJl3SqvvvzWxx4ItPyR0f7pI7Qp4xeMOg5KfdMgacThvsCigekB0rJGQ5F_CQ7CCXOmNMsmPyOMZrgHTV8hE5ZiIveAp35OdlwBYDurm3A52DdTGF1LcUXeOv0PklUv_Dht46GmcMvm9o58PoHUY6ezp3SJeUT6xZQu-uaOXn7k-69cPQ18tgA7WuoUNiqcfU2YjxCTlq7RDx6XaekC_v333eH7Kziw8f92_PsroQcs5Ua5kCofJcAxMooRJtjVBpIbEUFaiC1bIQSlRlw9FKJSsBRdVCmT7Ka8lPyKu17hT8zYJxNmMfaxwG6zB9zUipgetSJ_jiH3jtl-DS20zOmNYgc5ZQtqI6-BjT5MwU-tGGW8PA3K3DrOsw6zqSf74VXaoRm3u9zT-BlxuwsbZDm-Zf9_HeSSi1Vnfu9er8Mv235_bGPq3r119sw3cjFVfCHL5-M58kHJjen5tL_htjV7Kj</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Cicinelli, Ettore</creator><creator>Einer-Jensen, Niels</creator><creator>Cignarelli, Mauro</creator><creator>Mangiacotti, Lucia</creator><creator>Luisi, Diletta</creator><creator>Schonauer, Sergio</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Preferential transfer of endogenous ovarian steroid hormones to the uterus during both the follicular and luteal phases</title><author>Cicinelli, Ettore ; Einer-Jensen, Niels ; Cignarelli, Mauro ; Mangiacotti, Lucia ; Luisi, Diletta ; Schonauer, Sergio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-7fa17057228015e60b5fce0b856e95b0741c64575b9d3ea676b504bf091863c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Arteries</topic><topic>Biological and medical sciences</topic><topic>blood supply</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Follicular Phase - blood</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>local transfer</topic><topic>Luteal Phase - blood</topic><topic>Middle Aged</topic><topic>ovarian steroids</topic><topic>Progesterone - blood</topic><topic>tube</topic><topic>uterus</topic><topic>Uterus - blood supply</topic><topic>Veins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cicinelli, Ettore</creatorcontrib><creatorcontrib>Einer-Jensen, Niels</creatorcontrib><creatorcontrib>Cignarelli, Mauro</creatorcontrib><creatorcontrib>Mangiacotti, Lucia</creatorcontrib><creatorcontrib>Luisi, Diletta</creatorcontrib><creatorcontrib>Schonauer, Sergio</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cicinelli, Ettore</au><au>Einer-Jensen, Niels</au><au>Cignarelli, Mauro</au><au>Mangiacotti, Lucia</au><au>Luisi, Diletta</au><au>Schonauer, Sergio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preferential transfer of endogenous ovarian steroid hormones to the uterus during both the follicular and luteal phases</atitle><jtitle>Human reproduction (Oxford)</jtitle><stitle>Hum. Reprod</stitle><addtitle>Hum. Reprod</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>19</volume><issue>9</issue><spage>2001</spage><epage>2004</epage><pages>2001-2004</pages><issn>0268-1161</issn><issn>1460-2350</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>BACKGROUND: Ovarian steroids are thought to be released into the systemic circulation and reach the uterus via the uterine arteries. However, results of experimental and clinical studies suggest the existence of local transfer of steroids from the ovary to the uterus. This study aimed to verify the existence of preferential distribution of ovarian steroids to the uterus in the two phases of the menstrual cycle. METHODS: We performed parallel measurements of serum levels of estradiol and progesterone in the systemic circulation (arterial and venous) and in the uterine vessels in two groups of cycling women; one group were in the follicular phase (six women) and the other group were in the luteal phase (10 women) of the menstrual cycle. RESULTS: Both in the follicular phase and in the luteal phase groups, mean estradiol levels in the uterine blood were significantly higher than in both sides of the systemic circulation (F=7.30, df =15, P<0.006; and F=4.70, df =27, P<0.02). Similar results were obtained in the luteal phase group for progesterone (F=9.38, df =27, P<0.0001). Both estradiol and progesterone levels in arterial and venous systemic blood were similar. CONCLUSIONS: The results of this study demonstrate that ovarian steroid levels are significantly higher in the uterine vessels than in both sides of the systemic blood circulation, and strongly suggest the existence in the female pelvis of mechanisms of local distribution of ovarian hormones.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15243001</pmid><doi>10.1093/humrep/deh404</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB Electronic Journals Library |
| subjects | Adult Arteries Biological and medical sciences blood supply Embryology: invertebrates and vertebrates. Teratology Estradiol - blood Female Follicular Phase - blood Fundamental and applied biological sciences. Psychology Humans local transfer Luteal Phase - blood Middle Aged ovarian steroids Progesterone - blood tube uterus Uterus - blood supply Veins |
| title | Preferential transfer of endogenous ovarian steroid hormones to the uterus during both the follicular and luteal phases |
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