Number of metastatic sentinel nodes as predictor of axillary involvement in patients with breast cancer
More than half of patients with positive sentinel node (SN) have no metastases in non-sentinel nodes (NSNs) on axillary lymph node dissection (ALND). The aim of this study was to investigate factors predictive of NSNs involvement, in order to identify patients with metastatic disease confined to the...
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| Veröffentlicht in: | Breast cancer research and treatment 2004-07, Vol.86 (2), p.171-179 |
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| creator | ZAVAGNO, Giorgio DE SALVO, Gian Luca BOZZA, Fernando SCALCO, Giuliano MARCONATO, Renato VALLETTA, Stefano RACANO, Carlo BURELLI, Paolo NITTI, Donate LISE, Mario |
| description | More than half of patients with positive sentinel node (SN) have no metastases in non-sentinel nodes (NSNs) on axillary lymph node dissection (ALND). The aim of this study was to investigate factors predictive of NSNs involvement, in order to identify patients with metastatic disease confined to the SN which might avoid ALND.
ALND was performed in 167 patients with metastatic SN. Axillary NSNs status was correlated with the size of SN metastases, the size of the primary tumor and the occurrence of lymphovascular invasion. In 72 cases, the radiotracer (Tc-99m albumin colloid) marked multiple (in most cases 2 or 3) nodes. In this group, NSNs status was correlated with the number of metastatic radioactive nodes (1 or > 1), and with the above mentioned histopathologic factors.
NSNs metastases were found in 57/167 cases (34.1%), the rate increasing proportionate to the size of both SN metastases (p < 0.0001) and primary tumor (p = 0.0075), while no significant correlation was found for lymphovascular invasion (p = 0.1769). At univariate and multivariate analysis of findings from the 72 cases with multiple probe-detected hot nodes, positivity in more than one hot node was the strongest predictor of NSN involvement (p = 0.0019).
The identification and excision of multiple hot nodes can be useful in the prediction of NSNs involvement in patients with metastatic SN. |
| doi_str_mv | 10.1023/B:BREA.0000032985.28558.6d |
| format | Article |
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ALND was performed in 167 patients with metastatic SN. Axillary NSNs status was correlated with the size of SN metastases, the size of the primary tumor and the occurrence of lymphovascular invasion. In 72 cases, the radiotracer (Tc-99m albumin colloid) marked multiple (in most cases 2 or 3) nodes. In this group, NSNs status was correlated with the number of metastatic radioactive nodes (1 or > 1), and with the above mentioned histopathologic factors.
NSNs metastases were found in 57/167 cases (34.1%), the rate increasing proportionate to the size of both SN metastases (p < 0.0001) and primary tumor (p = 0.0075), while no significant correlation was found for lymphovascular invasion (p = 0.1769). At univariate and multivariate analysis of findings from the 72 cases with multiple probe-detected hot nodes, positivity in more than one hot node was the strongest predictor of NSN involvement (p = 0.0019).
The identification and excision of multiple hot nodes can be useful in the prediction of NSNs involvement in patients with metastatic SN.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1023/B:BREA.0000032985.28558.6d</identifier><identifier>PMID: 15319569</identifier><identifier>CODEN: BCTRD6</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Axilla ; Biological and medical sciences ; Biopsy ; Breast cancer ; Breast Neoplasms - pathology ; Cancer research ; Diagnostic tests ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Lymph Node Excision ; Lymphatic Metastasis - diagnostic imaging ; Lymphatic system ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Predictive Value of Tests ; Radionuclide Imaging ; Radiopharmaceuticals ; Sensitivity and Specificity ; Sentinel Lymph Node Biopsy ; Technetium Tc 99m Aggregated Albumin ; Tumors</subject><ispartof>Breast cancer research and treatment, 2004-07, Vol.86 (2), p.171-179</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Kluwer Academic Publishers</rights><rights>Copyright Kluwer Academic Publishers Jul 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-75772cffe73ff225a9c7f6d9428f763d61cc56bdec02df85695aab7c0b2a58db3</citedby><cites>FETCH-LOGICAL-c372t-75772cffe73ff225a9c7f6d9428f763d61cc56bdec02df85695aab7c0b2a58db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15925393$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15319569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZAVAGNO, Giorgio</creatorcontrib><creatorcontrib>DE SALVO, Gian Luca</creatorcontrib><creatorcontrib>BOZZA, Fernando</creatorcontrib><creatorcontrib>SCALCO, Giuliano</creatorcontrib><creatorcontrib>MARCONATO, Renato</creatorcontrib><creatorcontrib>VALLETTA, Stefano</creatorcontrib><creatorcontrib>RACANO, Carlo</creatorcontrib><creatorcontrib>BURELLI, Paolo</creatorcontrib><creatorcontrib>NITTI, Donate</creatorcontrib><creatorcontrib>LISE, Mario</creatorcontrib><title>Number of metastatic sentinel nodes as predictor of axillary involvement in patients with breast cancer</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><description>More than half of patients with positive sentinel node (SN) have no metastases in non-sentinel nodes (NSNs) on axillary lymph node dissection (ALND). The aim of this study was to investigate factors predictive of NSNs involvement, in order to identify patients with metastatic disease confined to the SN which might avoid ALND.
ALND was performed in 167 patients with metastatic SN. Axillary NSNs status was correlated with the size of SN metastases, the size of the primary tumor and the occurrence of lymphovascular invasion. In 72 cases, the radiotracer (Tc-99m albumin colloid) marked multiple (in most cases 2 or 3) nodes. In this group, NSNs status was correlated with the number of metastatic radioactive nodes (1 or > 1), and with the above mentioned histopathologic factors.
NSNs metastases were found in 57/167 cases (34.1%), the rate increasing proportionate to the size of both SN metastases (p < 0.0001) and primary tumor (p = 0.0075), while no significant correlation was found for lymphovascular invasion (p = 0.1769). At univariate and multivariate analysis of findings from the 72 cases with multiple probe-detected hot nodes, positivity in more than one hot node was the strongest predictor of NSN involvement (p = 0.0019).
The identification and excision of multiple hot nodes can be useful in the prediction of NSNs involvement in patients with metastatic SN.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Axilla</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer research</subject><subject>Diagnostic tests</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Lymph Node Excision</subject><subject>Lymphatic Metastasis - diagnostic imaging</subject><subject>Lymphatic system</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Predictive Value of Tests</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals</subject><subject>Sensitivity and Specificity</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Technetium Tc 99m Aggregated Albumin</subject><subject>Tumors</subject><issn>0167-6806</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkctuFDEQRS1ERIbALyArEux64sfYbmeXicJDihIJwdpy22Vw1I_B7k7g76lJRgrCm6rFueWqewk55WzNmZBn2_Pt16uLNds_KWyr1qJVql3r-IKsuDKyMYKbl2TFuDaNbpk-Jq9rvUPcGmZfkWOuJLdK2xX5cbMMHRQ6JTrA7Ovs5xxohXHOI_R0nCJU6ivdFYg5zNMj6X_nvvflD83j_dTfw4A49nSHYmwrfcjzT9oVwHk0-DFAeUOOku8rvD3UE_L949W3y8_N9e2nL5cX102QRsyNUcaIkBIYmZIQyttgko52I9pktIyah6B0FyEwEVOLJyjvOxNYJ7xqYydPyIenubsy_Vqgzm7INQCuO8K0VKfRDim4RPD0P_BuWsqIuznBxWaDDgqEzp-gUKZaCyS3K3nAyx1nbp-F27p9Fu45C_eYhdMRxe8OPyzdAPFZejAfgfcHwNfg-1TQqVz_4axQ0kr5F9-TlJ4</recordid><startdate>20040701</startdate><enddate>20040701</enddate><creator>ZAVAGNO, Giorgio</creator><creator>DE SALVO, Gian Luca</creator><creator>BOZZA, Fernando</creator><creator>SCALCO, Giuliano</creator><creator>MARCONATO, Renato</creator><creator>VALLETTA, Stefano</creator><creator>RACANO, Carlo</creator><creator>BURELLI, Paolo</creator><creator>NITTI, Donate</creator><creator>LISE, Mario</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20040701</creationdate><title>Number of metastatic sentinel nodes as predictor of axillary involvement in patients with breast cancer</title><author>ZAVAGNO, Giorgio ; DE SALVO, Gian Luca ; BOZZA, Fernando ; SCALCO, Giuliano ; MARCONATO, Renato ; VALLETTA, Stefano ; RACANO, Carlo ; BURELLI, Paolo ; NITTI, Donate ; LISE, Mario</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-75772cffe73ff225a9c7f6d9428f763d61cc56bdec02df85695aab7c0b2a58db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Axilla</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer research</topic><topic>Diagnostic tests</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Lymph Node Excision</topic><topic>Lymphatic Metastasis - diagnostic imaging</topic><topic>Lymphatic system</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Predictive Value of Tests</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals</topic><topic>Sensitivity and Specificity</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>Technetium Tc 99m Aggregated Albumin</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZAVAGNO, Giorgio</creatorcontrib><creatorcontrib>DE SALVO, Gian Luca</creatorcontrib><creatorcontrib>BOZZA, Fernando</creatorcontrib><creatorcontrib>SCALCO, Giuliano</creatorcontrib><creatorcontrib>MARCONATO, Renato</creatorcontrib><creatorcontrib>VALLETTA, Stefano</creatorcontrib><creatorcontrib>RACANO, Carlo</creatorcontrib><creatorcontrib>BURELLI, Paolo</creatorcontrib><creatorcontrib>NITTI, Donate</creatorcontrib><creatorcontrib>LISE, Mario</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZAVAGNO, Giorgio</au><au>DE SALVO, Gian Luca</au><au>BOZZA, Fernando</au><au>SCALCO, Giuliano</au><au>MARCONATO, Renato</au><au>VALLETTA, Stefano</au><au>RACANO, Carlo</au><au>BURELLI, Paolo</au><au>NITTI, Donate</au><au>LISE, Mario</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Number of metastatic sentinel nodes as predictor of axillary involvement in patients with breast cancer</atitle><jtitle>Breast cancer research and treatment</jtitle><addtitle>Breast Cancer Res Treat</addtitle><date>2004-07-01</date><risdate>2004</risdate><volume>86</volume><issue>2</issue><spage>171</spage><epage>179</epage><pages>171-179</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><coden>BCTRD6</coden><abstract>More than half of patients with positive sentinel node (SN) have no metastases in non-sentinel nodes (NSNs) on axillary lymph node dissection (ALND). The aim of this study was to investigate factors predictive of NSNs involvement, in order to identify patients with metastatic disease confined to the SN which might avoid ALND.
ALND was performed in 167 patients with metastatic SN. Axillary NSNs status was correlated with the size of SN metastases, the size of the primary tumor and the occurrence of lymphovascular invasion. In 72 cases, the radiotracer (Tc-99m albumin colloid) marked multiple (in most cases 2 or 3) nodes. In this group, NSNs status was correlated with the number of metastatic radioactive nodes (1 or > 1), and with the above mentioned histopathologic factors.
NSNs metastases were found in 57/167 cases (34.1%), the rate increasing proportionate to the size of both SN metastases (p < 0.0001) and primary tumor (p = 0.0075), while no significant correlation was found for lymphovascular invasion (p = 0.1769). At univariate and multivariate analysis of findings from the 72 cases with multiple probe-detected hot nodes, positivity in more than one hot node was the strongest predictor of NSN involvement (p = 0.0019).
The identification and excision of multiple hot nodes can be useful in the prediction of NSNs involvement in patients with metastatic SN.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>15319569</pmid><doi>10.1023/B:BREA.0000032985.28558.6d</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Axilla Biological and medical sciences Biopsy Breast cancer Breast Neoplasms - pathology Cancer research Diagnostic tests Female Gynecology. Andrology. Obstetrics Humans Lymph Node Excision Lymphatic Metastasis - diagnostic imaging Lymphatic system Mammary gland diseases Medical sciences Middle Aged Multivariate Analysis Predictive Value of Tests Radionuclide Imaging Radiopharmaceuticals Sensitivity and Specificity Sentinel Lymph Node Biopsy Technetium Tc 99m Aggregated Albumin Tumors |
| title | Number of metastatic sentinel nodes as predictor of axillary involvement in patients with breast cancer |
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