Enhancement of Serum- and Platelet-derived Growth Factor-induced Cell Proliferation by Necl-5/Tage4/Poliovirus Receptor/CD155 through the Ras-Raf-MEK-ERK Signaling

Necl-5/Tage4/poliovirus receptor/CD155 has been shown to be the poliovirus receptor and to be up-regulated in rodent and human carcinoma. We have found previously that mouse Necl-5 regulates cell motility. We show here that mouse Necl-5 is furthermore involved in the regulation of cell proliferation...

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Veröffentlicht in:	The Journal of biological chemistry 2004-08, Vol.279 (35), p.36419-36425
Hauptverfasser:	Kakunaga, Shigeki, Ikeda, Wataru, Shingai, Tatsushi, Fujito, Tsutomu, Yamada, Akio, Minami, Yukiko, Imai, Toshio, Takai, Yoshimi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - chemistry Antigens, Neoplasm - metabolism CD55 Antigens - metabolism Cell Adhesion Molecules - metabolism Cell Cycle Proteins - metabolism Cell Division Cell Line Cyclin D2 Cyclin E - metabolism Cyclin-Dependent Kinase Inhibitor p27 Cyclins - metabolism Down-Regulation Fibroblasts - metabolism Flow Cytometry G1 Phase Gene Expression Regulation Humans Mice Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - metabolism Neoplasm Proteins - metabolism NIH 3T3 Cells Platelet-Derived Growth Factor - metabolism Poliovirus Proto-Oncogene Proteins c-raf - metabolism ras Proteins - metabolism Rats Resting Phase, Cell Cycle Retroviridae - genetics Signal Transduction Time Factors Tumor Suppressor Proteins - metabolism Up-Regulation
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