Doppel-induced cytotoxicity in human neuronal SH-SY5Y cells is antagonized by the prion protein

Doppel (Dpl) is a prion (PrP)-like protein due to the structural and biochemical similarities; however, the natural functions of Dpl and PrP remain unclear. In this study, a 531-bp human PRND gene sequence encoding Dpl protein was amplified from human peripheral blood leucocytes. Full-length and var...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2009-01, Vol.41 (1), p.42-53
Hauptverfasser:	Li, Ping, Dong, Chenfang, Lei, Yanjun, Shan, Bing, Xiao, Xinli, Jiang, Huiying, Wang, Xin, Gao, Chen, Shi, Qi, Xu, Kun, Tian, Chan, Han, Jun, Dong, Xiaoping
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Base Sequence Blotting, Western Cell Line, Tumor Cell Survival DNA Primers Escherichia coli Escherichia coli - genetics GPI-Linked Proteins Humans Neurons - cytology Neurons - enzymology Nitric Oxide Synthase - metabolism Polymerase Chain Reaction Prions - physiology
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