Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis

Ras-associated protein 1 (Rap1), a small GTPase, attracted attention because of its involvement in several aspects of cell adhesion, including integrin- and cadherin-mediated adhesion. Yet, the role of Rap1 genes and of Rap1 effectors for angiogenesis has not been investigated. Human umbilical vein...

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Veröffentlicht in:	Blood 2009-01, Vol.113 (2), p.488-497
Hauptverfasser:	Carmona, Guillaume, Göttig, Stephan, Orlandi, Alessia, Scheele, Jürgen, Bäuerle, Tobias, Jugold, Manfred, Kiessling, Fabian, Henschler, Reinhard, Zeiher, Andreas M., Dimmeler, Stefanie, Chavakis, Emmanouil
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Apoptosis Regulatory Proteins Cell Adhesion - physiology Cell Movement - physiology Endothelial Cells - cytology Endothelial Cells - enzymology Fibroblast Growth Factors - metabolism Focal Adhesion Kinase 1 - metabolism Gene Silencing GTPase-Activating Proteins - metabolism Hindlimb - blood supply Hindlimb - enzymology Humans Integrin beta1 - metabolism Ischemia - enzymology Mice Mice, Knockout Monomeric GTP-Binding Proteins - metabolism Neovascularization, Physiologic - physiology Phosphorylation - physiology Proto-Oncogene Proteins c-akt rap GTP-Binding Proteins - metabolism rap1 GTP-Binding Proteins - metabolism Umbilical Veins - cytology Umbilical Veins - enzymology
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