Ghrelin in small-for-gestational age (SGA) newborn babies: a cross-sectional study
Summary Background Small‐for‐gestational newborn babies may have long‐term metabolic consequences. Among the main hormones possibly involved in foetal growth regulation are the IGFs, IGFBPs and the recently described ghrelin. Objective To examine the levels of desacyl‐ghrelin, IGF‐1, IGFBP‐1 and I...
Gespeichert in:
| Veröffentlicht in: | Clinical endocrinology (Oxford) 2009-01, Vol.70 (1), p.41-46 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 46 |
|---|---|
| container_issue | 1 |
| container_start_page | 41 |
| container_title | Clinical endocrinology (Oxford) |
| container_volume | 70 |
| creator | Méndez-Ramírez, Francisco Barbosa-Sabanero, Gloria Romero-Gutiérrez, Gustavo Malacara, Juan Manuel |
| description | Summary
Background Small‐for‐gestational newborn babies may have long‐term metabolic consequences. Among the main hormones possibly involved in foetal growth regulation are the IGFs, IGFBPs and the recently described ghrelin.
Objective To examine the levels of desacyl‐ghrelin, IGF‐1, IGFBP‐1 and IGFBP‐3 in children Small‐for‐gestational age (SGA) and children adequate‐for‐gestational age (AGA).
Design This was a cross‐sectional and comparative study.
Subjects We included 40 children SGA and 40 children AGA.
Measurements Blood sample was taken a week after birth and measuring hormonal levels were done by ELISA.
Results SGA babies had lower IGF‐1, IGFBP‐3 and leptin levels, but higher ghrelin and IGFBP‐1 levels. Birth weight was associated independently with ghrelin and IGFBP‐1 (negatively) and IGFBP‐3 (positively). Ghrelin circulating levels were associated negative and independently with IGFBP‐3 and triglycerides in the mother.
Conclusions We interpreted these findings to indicate that diminished body weight in newborns induce different adaptive signals, some of them mediated by IGF‐1/IGFBP‐3, ghrelin or by IGFBP‐1. This regulation is congruent with the proposed role of ghrelin to adaptation to under‐nutrition favouring lipid accumulation. CONCyTEG grant number 05‐16‐K117‐028. |
| doi_str_mv | 10.1111/j.1365-2265.2008.03278.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66801468</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66801468</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4358-b2dfebd584a71872643c0990908a57b4522011fcc2f295108de9eeb32a3dd6863</originalsourceid><addsrcrecordid>eNqNkF1v0zAUhi0EYmXwF1BuQHDhcGzHH0HiYlRbgE0D8SEuLcc5GSluMuxWa_89yRqVWyxLtuTnPX71EJIxyNm43qxyJpSknCuZcwCTg-Da5LsHZHF8eEgWIAAoKFWckCcprQBAGtCPyQkzBSu1EQvytfoVMXR9Nu60diHQdoj0BtPGbbqhdyFzN5i9-ladvc56vKuH2Ge1qztMbzOX-TikRBP6mU2bbbN_Sh61LiR8Np-n5MfF-fflB3r1ufq4PLuivhDS0Jo3LdaNNIXTzGiuCuGhLKEE46SuC8k5MNZ6z1teSgamwRKxFtyJplFGiVPy8jD3Ng5_tmNju-6SxxBcj8M2WaUMsEKZETQH8L5uxNbexm7t4t4ysJNPu7KTNjtps5NPe-_T7sbo8_mPbb3G5l9wFjgCL2bAJe9CG13vu3TkOJQGQOuRe3fg7rqA-_8uYJfn19NtzNNDvksb3B3zLv62Sgst7c_ryn66eP-lqC65vRR_ARODnmg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66801468</pqid></control><display><type>article</type><title>Ghrelin in small-for-gestational age (SGA) newborn babies: a cross-sectional study</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Méndez-Ramírez, Francisco ; Barbosa-Sabanero, Gloria ; Romero-Gutiérrez, Gustavo ; Malacara, Juan Manuel</creator><creatorcontrib>Méndez-Ramírez, Francisco ; Barbosa-Sabanero, Gloria ; Romero-Gutiérrez, Gustavo ; Malacara, Juan Manuel</creatorcontrib><description>Summary
Background Small‐for‐gestational newborn babies may have long‐term metabolic consequences. Among the main hormones possibly involved in foetal growth regulation are the IGFs, IGFBPs and the recently described ghrelin.
Objective To examine the levels of desacyl‐ghrelin, IGF‐1, IGFBP‐1 and IGFBP‐3 in children Small‐for‐gestational age (SGA) and children adequate‐for‐gestational age (AGA).
Design This was a cross‐sectional and comparative study.
Subjects We included 40 children SGA and 40 children AGA.
Measurements Blood sample was taken a week after birth and measuring hormonal levels were done by ELISA.
Results SGA babies had lower IGF‐1, IGFBP‐3 and leptin levels, but higher ghrelin and IGFBP‐1 levels. Birth weight was associated independently with ghrelin and IGFBP‐1 (negatively) and IGFBP‐3 (positively). Ghrelin circulating levels were associated negative and independently with IGFBP‐3 and triglycerides in the mother.
Conclusions We interpreted these findings to indicate that diminished body weight in newborns induce different adaptive signals, some of them mediated by IGF‐1/IGFBP‐3, ghrelin or by IGFBP‐1. This regulation is congruent with the proposed role of ghrelin to adaptation to under‐nutrition favouring lipid accumulation. CONCyTEG grant number 05‐16‐K117‐028.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2008.03278.x</identifier><identifier>PMID: 18419783</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Cross-Sectional Studies ; Diseases of mother, fetus and pregnancy ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Gestational Age ; Ghrelin - blood ; Gynecology. Andrology. Obstetrics ; Humans ; Infant, Newborn ; Infant, Small for Gestational Age - blood ; Insulin-Like Growth Factor Binding Protein 1 - blood ; Insulin-Like Growth Factor Binding Protein 3 ; Insulin-Like Growth Factor Binding Proteins - blood ; Insulin-Like Growth Factor I - analysis ; Leptin - blood ; Male ; Medical sciences ; Pregnancy ; Pregnancy. Fetus. Placenta ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2009-01, Vol.70 (1), p.41-46</ispartof><rights>2009 The Authors. Journal compilation © 2009 Blackwell Publishing Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4358-b2dfebd584a71872643c0990908a57b4522011fcc2f295108de9eeb32a3dd6863</citedby><cites>FETCH-LOGICAL-c4358-b2dfebd584a71872643c0990908a57b4522011fcc2f295108de9eeb32a3dd6863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2008.03278.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2008.03278.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20980077$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18419783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Méndez-Ramírez, Francisco</creatorcontrib><creatorcontrib>Barbosa-Sabanero, Gloria</creatorcontrib><creatorcontrib>Romero-Gutiérrez, Gustavo</creatorcontrib><creatorcontrib>Malacara, Juan Manuel</creatorcontrib><title>Ghrelin in small-for-gestational age (SGA) newborn babies: a cross-sectional study</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Background Small‐for‐gestational newborn babies may have long‐term metabolic consequences. Among the main hormones possibly involved in foetal growth regulation are the IGFs, IGFBPs and the recently described ghrelin.
Objective To examine the levels of desacyl‐ghrelin, IGF‐1, IGFBP‐1 and IGFBP‐3 in children Small‐for‐gestational age (SGA) and children adequate‐for‐gestational age (AGA).
Design This was a cross‐sectional and comparative study.
Subjects We included 40 children SGA and 40 children AGA.
Measurements Blood sample was taken a week after birth and measuring hormonal levels were done by ELISA.
Results SGA babies had lower IGF‐1, IGFBP‐3 and leptin levels, but higher ghrelin and IGFBP‐1 levels. Birth weight was associated independently with ghrelin and IGFBP‐1 (negatively) and IGFBP‐3 (positively). Ghrelin circulating levels were associated negative and independently with IGFBP‐3 and triglycerides in the mother.
Conclusions We interpreted these findings to indicate that diminished body weight in newborns induce different adaptive signals, some of them mediated by IGF‐1/IGFBP‐3, ghrelin or by IGFBP‐1. This regulation is congruent with the proposed role of ghrelin to adaptation to under‐nutrition favouring lipid accumulation. CONCyTEG grant number 05‐16‐K117‐028.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gestational Age</subject><subject>Ghrelin - blood</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Small for Gestational Age - blood</subject><subject>Insulin-Like Growth Factor Binding Protein 1 - blood</subject><subject>Insulin-Like Growth Factor Binding Protein 3</subject><subject>Insulin-Like Growth Factor Binding Proteins - blood</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1v0zAUhi0EYmXwF1BuQHDhcGzHH0HiYlRbgE0D8SEuLcc5GSluMuxWa_89yRqVWyxLtuTnPX71EJIxyNm43qxyJpSknCuZcwCTg-Da5LsHZHF8eEgWIAAoKFWckCcprQBAGtCPyQkzBSu1EQvytfoVMXR9Nu60diHQdoj0BtPGbbqhdyFzN5i9-ladvc56vKuH2Ge1qztMbzOX-TikRBP6mU2bbbN_Sh61LiR8Np-n5MfF-fflB3r1ufq4PLuivhDS0Jo3LdaNNIXTzGiuCuGhLKEE46SuC8k5MNZ6z1teSgamwRKxFtyJplFGiVPy8jD3Ng5_tmNju-6SxxBcj8M2WaUMsEKZETQH8L5uxNbexm7t4t4ysJNPu7KTNjtps5NPe-_T7sbo8_mPbb3G5l9wFjgCL2bAJe9CG13vu3TkOJQGQOuRe3fg7rqA-_8uYJfn19NtzNNDvksb3B3zLv62Sgst7c_ryn66eP-lqC65vRR_ARODnmg</recordid><startdate>200901</startdate><enddate>200901</enddate><creator>Méndez-Ramírez, Francisco</creator><creator>Barbosa-Sabanero, Gloria</creator><creator>Romero-Gutiérrez, Gustavo</creator><creator>Malacara, Juan Manuel</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200901</creationdate><title>Ghrelin in small-for-gestational age (SGA) newborn babies: a cross-sectional study</title><author>Méndez-Ramírez, Francisco ; Barbosa-Sabanero, Gloria ; Romero-Gutiérrez, Gustavo ; Malacara, Juan Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4358-b2dfebd584a71872643c0990908a57b4522011fcc2f295108de9eeb32a3dd6863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gestational Age</topic><topic>Ghrelin - blood</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Small for Gestational Age - blood</topic><topic>Insulin-Like Growth Factor Binding Protein 1 - blood</topic><topic>Insulin-Like Growth Factor Binding Protein 3</topic><topic>Insulin-Like Growth Factor Binding Proteins - blood</topic><topic>Insulin-Like Growth Factor I - analysis</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Méndez-Ramírez, Francisco</creatorcontrib><creatorcontrib>Barbosa-Sabanero, Gloria</creatorcontrib><creatorcontrib>Romero-Gutiérrez, Gustavo</creatorcontrib><creatorcontrib>Malacara, Juan Manuel</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Méndez-Ramírez, Francisco</au><au>Barbosa-Sabanero, Gloria</au><au>Romero-Gutiérrez, Gustavo</au><au>Malacara, Juan Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ghrelin in small-for-gestational age (SGA) newborn babies: a cross-sectional study</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2009-01</date><risdate>2009</risdate><volume>70</volume><issue>1</issue><spage>41</spage><epage>46</epage><pages>41-46</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Background Small‐for‐gestational newborn babies may have long‐term metabolic consequences. Among the main hormones possibly involved in foetal growth regulation are the IGFs, IGFBPs and the recently described ghrelin.
Objective To examine the levels of desacyl‐ghrelin, IGF‐1, IGFBP‐1 and IGFBP‐3 in children Small‐for‐gestational age (SGA) and children adequate‐for‐gestational age (AGA).
Design This was a cross‐sectional and comparative study.
Subjects We included 40 children SGA and 40 children AGA.
Measurements Blood sample was taken a week after birth and measuring hormonal levels were done by ELISA.
Results SGA babies had lower IGF‐1, IGFBP‐3 and leptin levels, but higher ghrelin and IGFBP‐1 levels. Birth weight was associated independently with ghrelin and IGFBP‐1 (negatively) and IGFBP‐3 (positively). Ghrelin circulating levels were associated negative and independently with IGFBP‐3 and triglycerides in the mother.
Conclusions We interpreted these findings to indicate that diminished body weight in newborns induce different adaptive signals, some of them mediated by IGF‐1/IGFBP‐3, ghrelin or by IGFBP‐1. This regulation is congruent with the proposed role of ghrelin to adaptation to under‐nutrition favouring lipid accumulation. CONCyTEG grant number 05‐16‐K117‐028.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18419783</pmid><doi>10.1111/j.1365-2265.2008.03278.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-0664 |
| ispartof | Clinical endocrinology (Oxford), 2009-01, Vol.70 (1), p.41-46 |
| issn | 0300-0664 1365-2265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66801468 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Biological and medical sciences Cross-Sectional Studies Diseases of mother, fetus and pregnancy Endocrinopathies Female Fundamental and applied biological sciences. Psychology Gestational Age Ghrelin - blood Gynecology. Andrology. Obstetrics Humans Infant, Newborn Infant, Small for Gestational Age - blood Insulin-Like Growth Factor Binding Protein 1 - blood Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor Binding Proteins - blood Insulin-Like Growth Factor I - analysis Leptin - blood Male Medical sciences Pregnancy Pregnancy. Fetus. Placenta Vertebrates: endocrinology |
| title | Ghrelin in small-for-gestational age (SGA) newborn babies: a cross-sectional study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T23%3A57%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ghrelin%20in%20small-for-gestational%20age%20(SGA)%20newborn%20babies:%20a%20cross-sectional%20study&rft.jtitle=Clinical%20endocrinology%20(Oxford)&rft.au=M%C3%A9ndez-Ram%C3%ADrez,%20Francisco&rft.date=2009-01&rft.volume=70&rft.issue=1&rft.spage=41&rft.epage=46&rft.pages=41-46&rft.issn=0300-0664&rft.eissn=1365-2265&rft.coden=CLECAP&rft_id=info:doi/10.1111/j.1365-2265.2008.03278.x&rft_dat=%3Cproquest_cross%3E66801468%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=66801468&rft_id=info:pmid/18419783&rfr_iscdi=true |