A WNT4 Mutation Associated with Müllerian-Duct Regression and Virilization in a 46,XX Woman

WNT4, a secreted protein that suppresses male sexual differentiation, is thought to suppress the synthesis of gonadal androgen in females. These investigators describe a woman with no müllerian-derived structures, unilateral renal agenesis, and clinical signs of androgen excess who had a loss-of-fun...

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