Stabilizing or Destabilizing Oligodeoxynucleotide Duplexes Containing Single 2′-Deoxyuridine Residues with 5-Alkynyl Substituents

The 5‐position of pyrimidines in DNA duplexes offers a site for introducing alkynyl substituents that protrude into the major groove and thus do not sterically interfere with helix formation. Substituents introduced at the 5‐position of the deoxyuridine residue of dU:dA base pairs may stabilize dupl...

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