Medication Adherence and Associated Hemoglobin A1c in Type 2 Diabetes
BACKGROUND: Tight blood glucose control has been correlated with a reduction in diabetes complications. Adherence to antidiabetic medications is crucial to achieving blood glucose control. OBJECTIVE: To assess the relationship between good glucose control [glycosylated hemoglobin (HbA1c) levels] and...
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| Veröffentlicht in: | The Annals of pharmacotherapy 2004-09, Vol.38 (9), p.1357-1362 |
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| container_title | The Annals of pharmacotherapy |
| container_volume | 38 |
| creator | Krapek, Kimberley King, Kathleen Warren, Susan S George, Karen G Caputo, Dorothy A Mihelich, Karen Holst, Elizabeth M Nichol, Michael B Shi, Sheng G Livengood, Kevin B Walden, Steve Lubowski, Teresa J |
| description | BACKGROUND:
Tight blood glucose control has been correlated with a reduction in diabetes
complications. Adherence to antidiabetic medications is crucial to achieving blood
glucose control.
OBJECTIVE:
To assess the relationship between good glucose control [glycosylated hemoglobin
(HbA1c) levels] and adherence to prescribed treatment in patients on a
stable medication regimen for type 2 diabetes.
METHODS:
The Morisky survey, a 4–item questionnaire that predicts patient medication-taking
behavior, was used to assess adherence in 301 patients. The relationship of
HbA1c to Morisky score was evaluated, controlling for other variables
related to patient demographics and clinical characteristics. Data were analyzed using a
general linear model on log (HbA1c).
RESULTS:
Unadjusted mean HbA1c values (capped at 14.0%) for patients with Morisky
scores of 0 or 1, 2, 3, and 4 were 8.92%, 8.67%, 7.74%, and 7.60%, respectively. Of all
patients, 13.0%, 14.0%, 24.3%, and 48.8% had scores of 0 or 1, 2, 3, and 4,
respectively. Good adherence (Morisky score ≥3) was associated with a 10% lower total
HbA1c (p = 0.0003) adjusted for all other factors in the model. Duration of
diabetes (5–10 y) and presence of diabetes complications were also significantly
associated with HbA1c (p = 0.026 and 0.002, respectively). Adherence was poor
in 27% of patients.
CONCLUSIONS:
This study found that patients with a higher score on the Morisky scale had a lower
associated HbA1c measurement. The Morisky score may be an efficient tool for
identifying patients with poor medication-taking behavior who can then be targeted for
directed adherence counseling services. |
| doi_str_mv | 10.1345/aph.1D612 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_66796476</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1345_aph.1D612</sage_id><sourcerecordid>66796476</sourcerecordid><originalsourceid>FETCH-LOGICAL-h267t-4394b045ba0b6882a6c66ebb1f14365314399be32a1ad4cc980128c8237d42713</originalsourceid><addsrcrecordid>eNpFkEtPwzAQhC0EoqVw4A-gnLil-BXHOVZtoUhFXMrZsp1t4yov4kRR_z0Girjs7OHb0c4gdE_wnDCePOm2mJOVIPQCTUnCaSxoii_DjgWOMZV4gm68P2KMM0KzazQhCWVSUDJF6zfIndW9a-pokRfQQW0h0nUeLbxvrNM95NEGquZQNsYFhtgoyO7UQkSjldMGevC36GqvSw93Z52hj-f1brmJt-8vr8vFNi6oSPuYs4wbzBOjsRFSUi2sEGAM2RPORMLCzDIDjGqic25tJjGh0krK0pzTlLAZevz1bbvmcwDfq8p5C2Wpa2gGr4RIM8FTEcCHMziYCnLVdq7S3Un9Bf938voA6tgMXR0eVwSr70ZVaFT9NPoPFu5QjK4D5StdlsGXqHEcmVRZOElS9gW1WHBd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66796476</pqid></control><display><type>article</type><title>Medication Adherence and Associated Hemoglobin A1c in Type 2 Diabetes</title><source>Access via SAGE</source><source>MEDLINE</source><creator>Krapek, Kimberley ; King, Kathleen ; Warren, Susan S ; George, Karen G ; Caputo, Dorothy A ; Mihelich, Karen ; Holst, Elizabeth M ; Nichol, Michael B ; Shi, Sheng G ; Livengood, Kevin B ; Walden, Steve ; Lubowski, Teresa J</creator><creatorcontrib>Krapek, Kimberley ; King, Kathleen ; Warren, Susan S ; George, Karen G ; Caputo, Dorothy A ; Mihelich, Karen ; Holst, Elizabeth M ; Nichol, Michael B ; Shi, Sheng G ; Livengood, Kevin B ; Walden, Steve ; Lubowski, Teresa J</creatorcontrib><description>BACKGROUND:
Tight blood glucose control has been correlated with a reduction in diabetes
complications. Adherence to antidiabetic medications is crucial to achieving blood
glucose control.
OBJECTIVE:
To assess the relationship between good glucose control [glycosylated hemoglobin
(HbA1c) levels] and adherence to prescribed treatment in patients on a
stable medication regimen for type 2 diabetes.
METHODS:
The Morisky survey, a 4–item questionnaire that predicts patient medication-taking
behavior, was used to assess adherence in 301 patients. The relationship of
HbA1c to Morisky score was evaluated, controlling for other variables
related to patient demographics and clinical characteristics. Data were analyzed using a
general linear model on log (HbA1c).
RESULTS:
Unadjusted mean HbA1c values (capped at 14.0%) for patients with Morisky
scores of 0 or 1, 2, 3, and 4 were 8.92%, 8.67%, 7.74%, and 7.60%, respectively. Of all
patients, 13.0%, 14.0%, 24.3%, and 48.8% had scores of 0 or 1, 2, 3, and 4,
respectively. Good adherence (Morisky score ≥3) was associated with a 10% lower total
HbA1c (p = 0.0003) adjusted for all other factors in the model. Duration of
diabetes (5–10 y) and presence of diabetes complications were also significantly
associated with HbA1c (p = 0.026 and 0.002, respectively). Adherence was poor
in 27% of patients.
CONCLUSIONS:
This study found that patients with a higher score on the Morisky scale had a lower
associated HbA1c measurement. The Morisky score may be an efficient tool for
identifying patients with poor medication-taking behavior who can then be targeted for
directed adherence counseling services.</description><identifier>ISSN: 1060-0280</identifier><identifier>EISSN: 1542-6270</identifier><identifier>DOI: 10.1345/aph.1D612</identifier><identifier>PMID: 15238621</identifier><language>eng</language><publisher>Los Angeles, CA: Harvey Whitney Books</publisher><subject>Adolescent ; Adult ; Aged ; Blood Glucose - analysis ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - drug therapy ; Female ; Glycated Hemoglobin A - analysis ; Humans ; Hypoglycemic Agents - therapeutic use ; Insulin - therapeutic use ; Linear Models ; Male ; Middle Aged ; Patient Compliance - statistics & numerical data ; Patient Education as Topic ; Surveys and Questionnaires</subject><ispartof>The Annals of pharmacotherapy, 2004-09, Vol.38 (9), p.1357-1362</ispartof><rights>2004 SAGE Publications</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1345/aph.1D612$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1345/aph.1D612$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15238621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krapek, Kimberley</creatorcontrib><creatorcontrib>King, Kathleen</creatorcontrib><creatorcontrib>Warren, Susan S</creatorcontrib><creatorcontrib>George, Karen G</creatorcontrib><creatorcontrib>Caputo, Dorothy A</creatorcontrib><creatorcontrib>Mihelich, Karen</creatorcontrib><creatorcontrib>Holst, Elizabeth M</creatorcontrib><creatorcontrib>Nichol, Michael B</creatorcontrib><creatorcontrib>Shi, Sheng G</creatorcontrib><creatorcontrib>Livengood, Kevin B</creatorcontrib><creatorcontrib>Walden, Steve</creatorcontrib><creatorcontrib>Lubowski, Teresa J</creatorcontrib><title>Medication Adherence and Associated Hemoglobin A1c in Type 2 Diabetes</title><title>The Annals of pharmacotherapy</title><addtitle>Ann Pharmacother</addtitle><description>BACKGROUND:
Tight blood glucose control has been correlated with a reduction in diabetes
complications. Adherence to antidiabetic medications is crucial to achieving blood
glucose control.
OBJECTIVE:
To assess the relationship between good glucose control [glycosylated hemoglobin
(HbA1c) levels] and adherence to prescribed treatment in patients on a
stable medication regimen for type 2 diabetes.
METHODS:
The Morisky survey, a 4–item questionnaire that predicts patient medication-taking
behavior, was used to assess adherence in 301 patients. The relationship of
HbA1c to Morisky score was evaluated, controlling for other variables
related to patient demographics and clinical characteristics. Data were analyzed using a
general linear model on log (HbA1c).
RESULTS:
Unadjusted mean HbA1c values (capped at 14.0%) for patients with Morisky
scores of 0 or 1, 2, 3, and 4 were 8.92%, 8.67%, 7.74%, and 7.60%, respectively. Of all
patients, 13.0%, 14.0%, 24.3%, and 48.8% had scores of 0 or 1, 2, 3, and 4,
respectively. Good adherence (Morisky score ≥3) was associated with a 10% lower total
HbA1c (p = 0.0003) adjusted for all other factors in the model. Duration of
diabetes (5–10 y) and presence of diabetes complications were also significantly
associated with HbA1c (p = 0.026 and 0.002, respectively). Adherence was poor
in 27% of patients.
CONCLUSIONS:
This study found that patients with a higher score on the Morisky scale had a lower
associated HbA1c measurement. The Morisky score may be an efficient tool for
identifying patients with poor medication-taking behavior who can then be targeted for
directed adherence counseling services.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Blood Glucose - analysis</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Female</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulin - therapeutic use</subject><subject>Linear Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patient Compliance - statistics & numerical data</subject><subject>Patient Education as Topic</subject><subject>Surveys and Questionnaires</subject><issn>1060-0280</issn><issn>1542-6270</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPwzAQhC0EoqVw4A-gnLil-BXHOVZtoUhFXMrZsp1t4yov4kRR_z0Girjs7OHb0c4gdE_wnDCePOm2mJOVIPQCTUnCaSxoii_DjgWOMZV4gm68P2KMM0KzazQhCWVSUDJF6zfIndW9a-pokRfQQW0h0nUeLbxvrNM95NEGquZQNsYFhtgoyO7UQkSjldMGevC36GqvSw93Z52hj-f1brmJt-8vr8vFNi6oSPuYs4wbzBOjsRFSUi2sEGAM2RPORMLCzDIDjGqic25tJjGh0krK0pzTlLAZevz1bbvmcwDfq8p5C2Wpa2gGr4RIM8FTEcCHMziYCnLVdq7S3Un9Bf938voA6tgMXR0eVwSr70ZVaFT9NPoPFu5QjK4D5StdlsGXqHEcmVRZOElS9gW1WHBd</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Krapek, Kimberley</creator><creator>King, Kathleen</creator><creator>Warren, Susan S</creator><creator>George, Karen G</creator><creator>Caputo, Dorothy A</creator><creator>Mihelich, Karen</creator><creator>Holst, Elizabeth M</creator><creator>Nichol, Michael B</creator><creator>Shi, Sheng G</creator><creator>Livengood, Kevin B</creator><creator>Walden, Steve</creator><creator>Lubowski, Teresa J</creator><general>Harvey Whitney Books</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Medication Adherence and Associated Hemoglobin A1c in Type 2 Diabetes</title><author>Krapek, Kimberley ; King, Kathleen ; Warren, Susan S ; George, Karen G ; Caputo, Dorothy A ; Mihelich, Karen ; Holst, Elizabeth M ; Nichol, Michael B ; Shi, Sheng G ; Livengood, Kevin B ; Walden, Steve ; Lubowski, Teresa J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h267t-4394b045ba0b6882a6c66ebb1f14365314399be32a1ad4cc980128c8237d42713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Blood Glucose - analysis</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Female</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Insulin - therapeutic use</topic><topic>Linear Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patient Compliance - statistics & numerical data</topic><topic>Patient Education as Topic</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krapek, Kimberley</creatorcontrib><creatorcontrib>King, Kathleen</creatorcontrib><creatorcontrib>Warren, Susan S</creatorcontrib><creatorcontrib>George, Karen G</creatorcontrib><creatorcontrib>Caputo, Dorothy A</creatorcontrib><creatorcontrib>Mihelich, Karen</creatorcontrib><creatorcontrib>Holst, Elizabeth M</creatorcontrib><creatorcontrib>Nichol, Michael B</creatorcontrib><creatorcontrib>Shi, Sheng G</creatorcontrib><creatorcontrib>Livengood, Kevin B</creatorcontrib><creatorcontrib>Walden, Steve</creatorcontrib><creatorcontrib>Lubowski, Teresa J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krapek, Kimberley</au><au>King, Kathleen</au><au>Warren, Susan S</au><au>George, Karen G</au><au>Caputo, Dorothy A</au><au>Mihelich, Karen</au><au>Holst, Elizabeth M</au><au>Nichol, Michael B</au><au>Shi, Sheng G</au><au>Livengood, Kevin B</au><au>Walden, Steve</au><au>Lubowski, Teresa J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medication Adherence and Associated Hemoglobin A1c in Type 2 Diabetes</atitle><jtitle>The Annals of pharmacotherapy</jtitle><addtitle>Ann Pharmacother</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>38</volume><issue>9</issue><spage>1357</spage><epage>1362</epage><pages>1357-1362</pages><issn>1060-0280</issn><eissn>1542-6270</eissn><abstract>BACKGROUND:
Tight blood glucose control has been correlated with a reduction in diabetes
complications. Adherence to antidiabetic medications is crucial to achieving blood
glucose control.
OBJECTIVE:
To assess the relationship between good glucose control [glycosylated hemoglobin
(HbA1c) levels] and adherence to prescribed treatment in patients on a
stable medication regimen for type 2 diabetes.
METHODS:
The Morisky survey, a 4–item questionnaire that predicts patient medication-taking
behavior, was used to assess adherence in 301 patients. The relationship of
HbA1c to Morisky score was evaluated, controlling for other variables
related to patient demographics and clinical characteristics. Data were analyzed using a
general linear model on log (HbA1c).
RESULTS:
Unadjusted mean HbA1c values (capped at 14.0%) for patients with Morisky
scores of 0 or 1, 2, 3, and 4 were 8.92%, 8.67%, 7.74%, and 7.60%, respectively. Of all
patients, 13.0%, 14.0%, 24.3%, and 48.8% had scores of 0 or 1, 2, 3, and 4,
respectively. Good adherence (Morisky score ≥3) was associated with a 10% lower total
HbA1c (p = 0.0003) adjusted for all other factors in the model. Duration of
diabetes (5–10 y) and presence of diabetes complications were also significantly
associated with HbA1c (p = 0.026 and 0.002, respectively). Adherence was poor
in 27% of patients.
CONCLUSIONS:
This study found that patients with a higher score on the Morisky scale had a lower
associated HbA1c measurement. The Morisky score may be an efficient tool for
identifying patients with poor medication-taking behavior who can then be targeted for
directed adherence counseling services.</abstract><cop>Los Angeles, CA</cop><pub>Harvey Whitney Books</pub><pmid>15238621</pmid><doi>10.1345/aph.1D612</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Annals of pharmacotherapy, 2004-09, Vol.38 (9), p.1357-1362 |
| issn | 1060-0280 1542-6270 |
| language | eng |
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| source | Access via SAGE; MEDLINE |
| subjects | Adolescent Adult Aged Blood Glucose - analysis Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Female Glycated Hemoglobin A - analysis Humans Hypoglycemic Agents - therapeutic use Insulin - therapeutic use Linear Models Male Middle Aged Patient Compliance - statistics & numerical data Patient Education as Topic Surveys and Questionnaires |
| title | Medication Adherence and Associated Hemoglobin A1c in Type 2 Diabetes |
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