Drug discovery: estrogen-related compounds in mouse models of Alzheimer's disease

Despite promising epidemiological studies that showed a decreased incidence of Alzheimer disease (AD) in women who used hormone replacement therapy (HRT), the results of the recently released Women's Health Initiative Memory Study has dampened any enthusiasm for the use of HRT in women to preve...

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Veröffentlicht in:	Journal of molecular neuroscience 2004-01, Vol.24 (1), p.145-148
Hauptverfasser:	Smith, Jonathan D, Chakrabarti, Enakshi, Levin-Allerhand, Justine A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - genetics Alzheimer Disease - metabolism Amyloid beta-Peptides - biosynthesis Amyloid beta-Peptides - secretion Amyloid beta-Protein Precursor - drug effects Amyloid beta-Protein Precursor - metabolism Animals COS Cells Disease Models, Animal Down-Regulation - drug effects Down-Regulation - physiology Drug Design Drug Evaluation, Preclinical Estrogens - pharmacology Estrogens - therapeutic use Female Hormone replacement therapy Humans Medical research Mice Mice, Transgenic Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Nootropic Agents - pharmacology Nootropic Agents - therapeutic use Rodents Treatment Outcome Womens health
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