Proline substitutions are not easily accommodated in a membrane protein

Proline residues are relatively common in transmembrane helices. This suggests that proline substitutions may be readily tolerated in membrane proteins, even though they invariably produce deviations from canonical helical structure. We have experimentally tested this possibility by making proline s...

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Veröffentlicht in:	Journal of molecular biology 2004-07, Vol.341 (1), p.1-6
Hauptverfasser:	Yohannan, Sarah, Yang, Duan, Faham, Salem, Boulting, Gabriella, Whitelegge, Julian, Bowie, James U
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution - genetics Bacteriorhodopsins - chemistry Bacteriorhodopsins - genetics Membrane Proteins - chemistry Membrane Proteins - genetics Proline - genetics Protein Structure, Tertiary
Online-Zugang:	Volltext
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