Metabolism of bromhexine in pig hepatocyte cultures

The metabolism of bromhexine [N-cyclohexyl-N-methyl-2-(2-amino-3,5-dibromo-benzyl)-amine] was studied using pig hepatocyte cultures and LC/MS/MS techniques. Phase I 'single-step' reactions, i.e. hydroxylation and demethylation occurred the fastest whereas the formation of hydroxylated/deme...

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Veröffentlicht in:	Journal of veterinary pharmacology and therapeutics 2004-08, Vol.27 (4), p.219-225
Hauptverfasser:	Meijer, L.A, Verstegen, J.C.M, Bull, S, Fink-Gremmels, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anthranilic acid bromhexine Bromhexine - chemistry Bromhexine - metabolism cell culture Cells, Cultured chemical concentration chemical reactions chemical structure demethylation expectorants Expectorants - chemistry Expectorants - metabolism glucuronic acid hepatocytes Hepatocytes - metabolism hydroxylation Mass Spectrometry metabolites Molecular Structure pharmacology Swine - metabolism
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