Potent inhibition of human leukocyte elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamide derivatives

The design, synthesis, and in vitro biochemical evaluation of a class of mechanism-based inhibitors of human leukocyte elastase (HLE) that incorporate in their structure a 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold with appropriate recognition and reactivity elements appended to it is described...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2004-09, Vol.429 (2), p.191-197
Hauptverfasser:	Lai, Zhong, Gan, Xiangdong, Wei, Liuqing, Alliston, Kevin R., Yu, Hongyi, Li, Yue H., Groutas, William C.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,5-Thiadiazolidin-3-one 1,1 dioxide scaffold Cyclic S-Oxides - chemistry Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Human leukocyte elastase Humans Leukocyte Elastase - antagonists & inhibitors Magnetic Resonance Spectroscopy Mechanism-based inhibitors Sulfonamides - chemistry Sulfonamides - pharmacology Thiazoles - chemistry
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