Role of the endothelium in modulating neointimal formation: Vasculoprotective approaches to attenuate restenosis after percutaneous coronary interventions
Restenosis at the site of an endoluminal procedure remains a significant problem in the practice of interventional cardiology. We present current data on intimal hyperplasia, which identify the major role of endothelial cells (ECs) in the development of restenosis. Considering endothelial denudation...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2004-08, Vol.44 (4), p.733-739 |
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| container_title | Journal of the American College of Cardiology |
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| creator | KIPSHIDZE, Nicholas DANGAS, George TSAPENKO, Mykola MOSES, Jeffrey LEON, Martin B KUTRYK, Michael SERRUYS, Patrick |
| description | Restenosis at the site of an endoluminal procedure remains a significant problem in the practice of interventional cardiology. We present current data on intimal hyperplasia, which identify the major role of endothelial cells (ECs) in the development of restenosis. Considering endothelial denudation as one of the most important mechanisms contributing to restenosis, we focus more attention on methods of accelerating restoration of endothelial continuity. Prevention of restenosis may be achieved by promoting endothelial regeneration through the use of growth factors, EC seeding, vessel reconstruction with autologous EC/fibrin matrix, and the use of estrogen-loaded stents and stents designed to capture progenitor ECs. |
| doi_str_mv | 10.1016/j.jacc.2004.04.048 |
| format | Article |
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We present current data on intimal hyperplasia, which identify the major role of endothelial cells (ECs) in the development of restenosis. Considering endothelial denudation as one of the most important mechanisms contributing to restenosis, we focus more attention on methods of accelerating restoration of endothelial continuity. Prevention of restenosis may be achieved by promoting endothelial regeneration through the use of growth factors, EC seeding, vessel reconstruction with autologous EC/fibrin matrix, and the use of estrogen-loaded stents and stents designed to capture progenitor ECs.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2004.04.048</identifier><identifier>PMID: 15312851</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Science</publisher><subject>Angioplasty ; Angioplasty, Balloon, Coronary ; Atherosclerosis ; Biological and medical sciences ; Blood clots ; Cardiology ; Cardiology. Vascular system ; Coronary Artery Disease - therapy ; Coronary Restenosis ; Coronary vessels ; Diseases of the cardiovascular system ; Endothelium ; Endothelium, Vascular - pathology ; Feasibility studies ; Humans ; Medical sciences ; Permeability ; Radiotherapy. 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We present current data on intimal hyperplasia, which identify the major role of endothelial cells (ECs) in the development of restenosis. Considering endothelial denudation as one of the most important mechanisms contributing to restenosis, we focus more attention on methods of accelerating restoration of endothelial continuity. Prevention of restenosis may be achieved by promoting endothelial regeneration through the use of growth factors, EC seeding, vessel reconstruction with autologous EC/fibrin matrix, and the use of estrogen-loaded stents and stents designed to capture progenitor ECs.</description><subject>Angioplasty</subject><subject>Angioplasty, Balloon, Coronary</subject><subject>Atherosclerosis</subject><subject>Biological and medical sciences</subject><subject>Blood clots</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Artery Disease - therapy</subject><subject>Coronary Restenosis</subject><subject>Coronary vessels</subject><subject>Diseases of the cardiovascular system</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - pathology</subject><subject>Feasibility studies</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Permeability</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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Vascular system</topic><topic>Coronary Artery Disease - therapy</topic><topic>Coronary Restenosis</topic><topic>Coronary vessels</topic><topic>Diseases of the cardiovascular system</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - pathology</topic><topic>Feasibility studies</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Permeability</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Angioplasty Angioplasty, Balloon, Coronary Atherosclerosis Biological and medical sciences Blood clots Cardiology Cardiology. Vascular system Coronary Artery Disease - therapy Coronary Restenosis Coronary vessels Diseases of the cardiovascular system Endothelium Endothelium, Vascular - pathology Feasibility studies Humans Medical sciences Permeability Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Stents Veins & arteries |
| title | Role of the endothelium in modulating neointimal formation: Vasculoprotective approaches to attenuate restenosis after percutaneous coronary interventions |
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