Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer
Angiogenesis is essential for both primary and metastatic tumor growth. Tumor blood vessel formation is complex and regulated by many factors. Ovarian carcinomas have a poor prognosis, often associated with multifocal intraperitoneal dissemination accompanied by intense neovascularization. To examin...
Gespeichert in:
| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2004-08, Vol.64 (16), p.5535-5538 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 5538 |
|---|---|
| container_issue | 16 |
| container_start_page | 5535 |
| container_title | Cancer research (Chicago, Ill.) |
| container_volume | 64 |
| creator | CURIEL, Tyler J PUI CHENG LACKNER, Andrew CARMELIET, Peter WEIPING ZOU MOTTRAM, Peter ALVAREZ, Xavier MOONS, Lieve EVDEMON-HOGAN, Melina SHUANG WEI LINHUA ZOU KRYCZEK, Ilona HOYLE, Gary |
| description | Angiogenesis is essential for both primary and metastatic tumor growth. Tumor blood vessel formation is complex and regulated by many factors. Ovarian carcinomas have a poor prognosis, often associated with multifocal intraperitoneal dissemination accompanied by intense neovascularization. To examine tumor angiogenesis in the tumor microenvironment, we studied malignant ascites of patients with untreated ovarian carcinoma. We observed high numbers of plasmacytoid dendritic cells (PDCs) and significant stromal-derived factor (CXCL-12/SDF)-1 in their malignant ascites, attracting PDCs into the tumor environment. We now show that tumor-associated PDCs induced angiogenesis in vivo through production of tumor necrosis factor alpha and interleukin 8. By contrast, myeloid dendritic cells (MDCs) were absent from malignant ascites. MDCs derived in vitro suppressed angiogenesis in vivo through production of interleukin 12. Thus, the tumor may attract PDCs to augment angiogenesis while excluding MDCs to prevent angiogenesis inhibition, demonstrating a novel mechanism for modulating tumor neovascularization. Because dendritic cells (DCs) have long been known to affect tumor immunity, our data also implicate DCs in regulation of tumor neoangiogenesis, suggesting a novel role of DCs in tumor pathology. |
| doi_str_mv | 10.1158/0008-5472.can-04-1272 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66791544</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66791544</sourcerecordid><originalsourceid>FETCH-LOGICAL-c565t-1b6dd75b6a65bc796a903c2c10629ef3e4af55808efe678be2aab781d94632db3</originalsourceid><addsrcrecordid>eNqFkMtOwzAQRS0EoqXwCaBsYJdiO35lWZWnVMECWFuOMylGiVPsBKl_T6JWdMlqNNK58zgIXRI8J4SrW4yxSjmTdG6NTzFLCZX0CE0Jz1QqGePHaPrHTNBZjF9Dywnmp2gyQCRTSkzR2x34MrjO2cRCXSexLyJ0MSldVUEA3zlT19skwLqvTQeJ8WvXrsFDdDFxPvnsG-OT9scEN9ThFAvhHJ1Upo5wsa8z9PFw_758Slevj8_LxSq1XPAuJYUoS8kLYQQvrMyFyXFmqSVY0ByqDJipOFdYQQVCqgKoMYVUpMyZyGhZZDN0s5u7Ce13D7HTjYvjF8ZD20cthMwJZ-xfkOSSEsXIAPIdaEMbY4BKb4JrTNhqgvWoXY9K9ahULxcvGjM9ah9yV_sFfdFAeUjtPQ_A9R4w0Zq6CoMoFw-cwJQzwrJfNOKMLg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19721841</pqid></control><display><type>article</type><title>Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>CURIEL, Tyler J ; PUI CHENG ; LACKNER, Andrew ; CARMELIET, Peter ; WEIPING ZOU ; MOTTRAM, Peter ; ALVAREZ, Xavier ; MOONS, Lieve ; EVDEMON-HOGAN, Melina ; SHUANG WEI ; LINHUA ZOU ; KRYCZEK, Ilona ; HOYLE, Gary</creator><creatorcontrib>CURIEL, Tyler J ; PUI CHENG ; LACKNER, Andrew ; CARMELIET, Peter ; WEIPING ZOU ; MOTTRAM, Peter ; ALVAREZ, Xavier ; MOONS, Lieve ; EVDEMON-HOGAN, Melina ; SHUANG WEI ; LINHUA ZOU ; KRYCZEK, Ilona ; HOYLE, Gary</creatorcontrib><description>Angiogenesis is essential for both primary and metastatic tumor growth. Tumor blood vessel formation is complex and regulated by many factors. Ovarian carcinomas have a poor prognosis, often associated with multifocal intraperitoneal dissemination accompanied by intense neovascularization. To examine tumor angiogenesis in the tumor microenvironment, we studied malignant ascites of patients with untreated ovarian carcinoma. We observed high numbers of plasmacytoid dendritic cells (PDCs) and significant stromal-derived factor (CXCL-12/SDF)-1 in their malignant ascites, attracting PDCs into the tumor environment. We now show that tumor-associated PDCs induced angiogenesis in vivo through production of tumor necrosis factor alpha and interleukin 8. By contrast, myeloid dendritic cells (MDCs) were absent from malignant ascites. MDCs derived in vitro suppressed angiogenesis in vivo through production of interleukin 12. Thus, the tumor may attract PDCs to augment angiogenesis while excluding MDCs to prevent angiogenesis inhibition, demonstrating a novel mechanism for modulating tumor neovascularization. Because dendritic cells (DCs) have long been known to affect tumor immunity, our data also implicate DCs in regulation of tumor neoangiogenesis, suggesting a novel role of DCs in tumor pathology.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>DOI: 10.1158/0008-5472.can-04-1272</identifier><identifier>PMID: 15313886</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Animals ; Antineoplastic agents ; Ascites - metabolism ; Ascites - pathology ; Biological and medical sciences ; Dendritic Cells - classification ; Dendritic Cells - metabolism ; Dendritic Cells - physiology ; Female ; Humans ; Interleukin-12 - antagonists & inhibitors ; Interleukin-12 - biosynthesis ; Interleukin-8 - biosynthesis ; Medical sciences ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Myeloid Cells - metabolism ; Myeloid Cells - pathology ; Myeloid Cells - physiology ; Neovascularization, Pathologic - metabolism ; Neovascularization, Pathologic - pathology ; Ovarian Neoplasms - blood supply ; Ovarian Neoplasms - pathology ; Pharmacology. Drug treatments ; Tumor Necrosis Factor-alpha - biosynthesis ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 2004-08, Vol.64 (16), p.5535-5538</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-1b6dd75b6a65bc796a903c2c10629ef3e4af55808efe678be2aab781d94632db3</citedby><cites>FETCH-LOGICAL-c565t-1b6dd75b6a65bc796a903c2c10629ef3e4af55808efe678be2aab781d94632db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3356,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16025414$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15313886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CURIEL, Tyler J</creatorcontrib><creatorcontrib>PUI CHENG</creatorcontrib><creatorcontrib>LACKNER, Andrew</creatorcontrib><creatorcontrib>CARMELIET, Peter</creatorcontrib><creatorcontrib>WEIPING ZOU</creatorcontrib><creatorcontrib>MOTTRAM, Peter</creatorcontrib><creatorcontrib>ALVAREZ, Xavier</creatorcontrib><creatorcontrib>MOONS, Lieve</creatorcontrib><creatorcontrib>EVDEMON-HOGAN, Melina</creatorcontrib><creatorcontrib>SHUANG WEI</creatorcontrib><creatorcontrib>LINHUA ZOU</creatorcontrib><creatorcontrib>KRYCZEK, Ilona</creatorcontrib><creatorcontrib>HOYLE, Gary</creatorcontrib><title>Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Angiogenesis is essential for both primary and metastatic tumor growth. Tumor blood vessel formation is complex and regulated by many factors. Ovarian carcinomas have a poor prognosis, often associated with multifocal intraperitoneal dissemination accompanied by intense neovascularization. To examine tumor angiogenesis in the tumor microenvironment, we studied malignant ascites of patients with untreated ovarian carcinoma. We observed high numbers of plasmacytoid dendritic cells (PDCs) and significant stromal-derived factor (CXCL-12/SDF)-1 in their malignant ascites, attracting PDCs into the tumor environment. We now show that tumor-associated PDCs induced angiogenesis in vivo through production of tumor necrosis factor alpha and interleukin 8. By contrast, myeloid dendritic cells (MDCs) were absent from malignant ascites. MDCs derived in vitro suppressed angiogenesis in vivo through production of interleukin 12. Thus, the tumor may attract PDCs to augment angiogenesis while excluding MDCs to prevent angiogenesis inhibition, demonstrating a novel mechanism for modulating tumor neovascularization. Because dendritic cells (DCs) have long been known to affect tumor immunity, our data also implicate DCs in regulation of tumor neoangiogenesis, suggesting a novel role of DCs in tumor pathology.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Ascites - metabolism</subject><subject>Ascites - pathology</subject><subject>Biological and medical sciences</subject><subject>Dendritic Cells - classification</subject><subject>Dendritic Cells - metabolism</subject><subject>Dendritic Cells - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-12 - antagonists & inhibitors</subject><subject>Interleukin-12 - biosynthesis</subject><subject>Interleukin-8 - biosynthesis</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred NOD</subject><subject>Mice, SCID</subject><subject>Myeloid Cells - metabolism</subject><subject>Myeloid Cells - pathology</subject><subject>Myeloid Cells - physiology</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Ovarian Neoplasms - blood supply</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqXwCaBsYJdiO35lWZWnVMECWFuOMylGiVPsBKl_T6JWdMlqNNK58zgIXRI8J4SrW4yxSjmTdG6NTzFLCZX0CE0Jz1QqGePHaPrHTNBZjF9Dywnmp2gyQCRTSkzR2x34MrjO2cRCXSexLyJ0MSldVUEA3zlT19skwLqvTQeJ8WvXrsFDdDFxPvnsG-OT9scEN9ThFAvhHJ1Upo5wsa8z9PFw_758Slevj8_LxSq1XPAuJYUoS8kLYQQvrMyFyXFmqSVY0ByqDJipOFdYQQVCqgKoMYVUpMyZyGhZZDN0s5u7Ce13D7HTjYvjF8ZD20cthMwJZ-xfkOSSEsXIAPIdaEMbY4BKb4JrTNhqgvWoXY9K9ahULxcvGjM9ah9yV_sFfdFAeUjtPQ_A9R4w0Zq6CoMoFw-cwJQzwrJfNOKMLg</recordid><startdate>20040815</startdate><enddate>20040815</enddate><creator>CURIEL, Tyler J</creator><creator>PUI CHENG</creator><creator>LACKNER, Andrew</creator><creator>CARMELIET, Peter</creator><creator>WEIPING ZOU</creator><creator>MOTTRAM, Peter</creator><creator>ALVAREZ, Xavier</creator><creator>MOONS, Lieve</creator><creator>EVDEMON-HOGAN, Melina</creator><creator>SHUANG WEI</creator><creator>LINHUA ZOU</creator><creator>KRYCZEK, Ilona</creator><creator>HOYLE, Gary</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040815</creationdate><title>Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer</title><author>CURIEL, Tyler J ; PUI CHENG ; LACKNER, Andrew ; CARMELIET, Peter ; WEIPING ZOU ; MOTTRAM, Peter ; ALVAREZ, Xavier ; MOONS, Lieve ; EVDEMON-HOGAN, Melina ; SHUANG WEI ; LINHUA ZOU ; KRYCZEK, Ilona ; HOYLE, Gary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-1b6dd75b6a65bc796a903c2c10629ef3e4af55808efe678be2aab781d94632db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Ascites - metabolism</topic><topic>Ascites - pathology</topic><topic>Biological and medical sciences</topic><topic>Dendritic Cells - classification</topic><topic>Dendritic Cells - metabolism</topic><topic>Dendritic Cells - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-12 - antagonists & inhibitors</topic><topic>Interleukin-12 - biosynthesis</topic><topic>Interleukin-8 - biosynthesis</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred NOD</topic><topic>Mice, SCID</topic><topic>Myeloid Cells - metabolism</topic><topic>Myeloid Cells - pathology</topic><topic>Myeloid Cells - physiology</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Ovarian Neoplasms - blood supply</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CURIEL, Tyler J</creatorcontrib><creatorcontrib>PUI CHENG</creatorcontrib><creatorcontrib>LACKNER, Andrew</creatorcontrib><creatorcontrib>CARMELIET, Peter</creatorcontrib><creatorcontrib>WEIPING ZOU</creatorcontrib><creatorcontrib>MOTTRAM, Peter</creatorcontrib><creatorcontrib>ALVAREZ, Xavier</creatorcontrib><creatorcontrib>MOONS, Lieve</creatorcontrib><creatorcontrib>EVDEMON-HOGAN, Melina</creatorcontrib><creatorcontrib>SHUANG WEI</creatorcontrib><creatorcontrib>LINHUA ZOU</creatorcontrib><creatorcontrib>KRYCZEK, Ilona</creatorcontrib><creatorcontrib>HOYLE, Gary</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CURIEL, Tyler J</au><au>PUI CHENG</au><au>LACKNER, Andrew</au><au>CARMELIET, Peter</au><au>WEIPING ZOU</au><au>MOTTRAM, Peter</au><au>ALVAREZ, Xavier</au><au>MOONS, Lieve</au><au>EVDEMON-HOGAN, Melina</au><au>SHUANG WEI</au><au>LINHUA ZOU</au><au>KRYCZEK, Ilona</au><au>HOYLE, Gary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>2004-08-15</date><risdate>2004</risdate><volume>64</volume><issue>16</issue><spage>5535</spage><epage>5538</epage><pages>5535-5538</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>Angiogenesis is essential for both primary and metastatic tumor growth. Tumor blood vessel formation is complex and regulated by many factors. Ovarian carcinomas have a poor prognosis, often associated with multifocal intraperitoneal dissemination accompanied by intense neovascularization. To examine tumor angiogenesis in the tumor microenvironment, we studied malignant ascites of patients with untreated ovarian carcinoma. We observed high numbers of plasmacytoid dendritic cells (PDCs) and significant stromal-derived factor (CXCL-12/SDF)-1 in their malignant ascites, attracting PDCs into the tumor environment. We now show that tumor-associated PDCs induced angiogenesis in vivo through production of tumor necrosis factor alpha and interleukin 8. By contrast, myeloid dendritic cells (MDCs) were absent from malignant ascites. MDCs derived in vitro suppressed angiogenesis in vivo through production of interleukin 12. Thus, the tumor may attract PDCs to augment angiogenesis while excluding MDCs to prevent angiogenesis inhibition, demonstrating a novel mechanism for modulating tumor neovascularization. Because dendritic cells (DCs) have long been known to affect tumor immunity, our data also implicate DCs in regulation of tumor neoangiogenesis, suggesting a novel role of DCs in tumor pathology.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>15313886</pmid><doi>10.1158/0008-5472.can-04-1272</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-5472 |
| ispartof | Cancer research (Chicago, Ill.), 2004-08, Vol.64 (16), p.5535-5538 |
| issn | 0008-5472 1538-7445 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66791544 |
| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antineoplastic agents Ascites - metabolism Ascites - pathology Biological and medical sciences Dendritic Cells - classification Dendritic Cells - metabolism Dendritic Cells - physiology Female Humans Interleukin-12 - antagonists & inhibitors Interleukin-12 - biosynthesis Interleukin-8 - biosynthesis Medical sciences Mice Mice, Inbred NOD Mice, SCID Myeloid Cells - metabolism Myeloid Cells - pathology Myeloid Cells - physiology Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Ovarian Neoplasms - blood supply Ovarian Neoplasms - pathology Pharmacology. Drug treatments Tumor Necrosis Factor-alpha - biosynthesis Tumors |
| title | Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T17%3A56%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dendritic%20cell%20subsets%20differentially%20regulate%20angiogenesis%20in%20human%20ovarian%20cancer&rft.jtitle=Cancer%20research%20(Chicago,%20Ill.)&rft.au=CURIEL,%20Tyler%20J&rft.date=2004-08-15&rft.volume=64&rft.issue=16&rft.spage=5535&rft.epage=5538&rft.pages=5535-5538&rft.issn=0008-5472&rft.eissn=1538-7445&rft.coden=CNREA8&rft_id=info:doi/10.1158/0008-5472.can-04-1272&rft_dat=%3Cproquest_cross%3E66791544%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19721841&rft_id=info:pmid/15313886&rfr_iscdi=true |