Contribution of a glial glutamate transporter to GABA synthesis in the retina

Neuronal glutamate transporters have been shown to play a role in GABA synthesis by enhancing glutamate uptake. In the present study, we have examined whether a glial glutamate transporter, GLAST, has a role in GABA synthesis in the mammalian retina. We found that the retinal GABA level was about tw...

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Veröffentlicht in:	Neuroreport 2004-08, Vol.15 (12), p.1895-1898
Hauptverfasser:	Sarthy, Vijay P, Marc, Robert E, Pignataro, Leonardo, Tanaka, Kohichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System X-AG - deficiency Amino Acid Transport System X-AG - genetics Amino Acid Transport System X-AG - physiology Amino Acids - metabolism Animals Biological and medical sciences Chromatography, High Pressure Liquid - methods Extracellular Space - metabolism Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - biosynthesis Glutamic Acid - metabolism Glutamine - metabolism Immunohistochemistry - methods Mice Mice, Inbred C57BL Mice, Knockout Neuroglia - metabolism Retina - cytology Retina - metabolism Vertebrates: nervous system and sense organs
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