Toll‐like receptor 9 binds single‐stranded CpG‐DNA in a sequence‐ and pH‐dependent manner

Toll‐like receptors (TLR) recognize bacterial and viral components, but direct interaction of receptor and ligand is unclear. Here, we demonstrate that TLR9 binds directly and sequence‐specifically to single‐stranded unmethylated CpG‐DNA containing a phosphodiester backbone. TLR9‐CpG‐DNA interaction...

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Veröffentlicht in:	European Journal of Immunology 2004-09, Vol.34 (9), p.2541-2550
Hauptverfasser:	Rutz, Mark, Metzger, Jochen, Gellert, Tanja, Luppa, Peter, Lipford, Grayson B., Wagner, Hermann, Bauer, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Cell Line Chloroquine Chloroquine - pharmacology CpG Islands CpG‐DNA DNA, Single-Stranded - metabolism Humans Hydrogen-Ion Concentration MBD domain Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Molecular Sequence Data Quinacrine - pharmacology Receptors, Cell Surface - chemistry Receptors, Cell Surface - metabolism Surface plasmon resonance (biacore) TLR9 Toll-Like Receptor 2 Toll-Like Receptor 9 Toll-Like Receptors
Online-Zugang:	Volltext
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