Nitrosulindac (NCX 1102): A new nitric oxide-donating non-steroidal anti-inflammatory drug (NO-NSAID), inhibits proliferation and induces apoptosis in human prostatic epithelial cell lines

BACKGROUND The aim of our study was to explore the anti‐tumoral potential of the Nitric Oxide‐Donating Non‐Steroidal Anti‐Inflammatory Drugs (NO‐NSAID) NCX1102 (nitrosulindac), on three human prostatic epithelial cell lines at varying degree of transformation (PNT1A, LNCaP, and PC3). METHODS Cytotox...

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Veröffentlicht in:	The Prostate 2004-10, Vol.61 (2), p.132-141
Hauptverfasser:	Huguenin, Sandra, Fleury-Feith, Jocelyne, Kheuang, Laurence, Jaurand, Marie-Claude, Bolla, Manlio, Riffaud, Jean-Pierre, Chopin, Dominique K., Vacherot, Francis
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - metabolism Anti-Inflammatory Agents, Non-Steroidal - pharmacology anti-proliferation Apoptosis - drug effects Biological and medical sciences Cell Cycle - drug effects cell death Cell Division - drug effects Cell Line Cell Line, Tumor Cell Survival - drug effects Epithelial Cells - drug effects Gynecology. Andrology. Obstetrics Humans Male Male genital diseases Medical sciences Nephrology. Urinary tract diseases Nitric Oxide - metabolism NO-NSAID Prostate - cytology prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - prevention & control Sulindac - analogs & derivatives Sulindac - metabolism Sulindac - pharmacology Tumors Tumors of the urinary system Urinary tract. Prostate gland
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