Synergistic activation of innate immunity by double-stranded RNA and CpG dna promotes enhanced antitumor activity

Double-stranded RNA (dsRNA) and unmethylated CpG sequences in DNA are pathogen-associated molecular patterns of viruses and bacteria that activate innate immunity. To examine whether dsRNA and CpG DNA could combine to provide enhanced stimulation of innate immune cells, murine macrophages were stimu...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2004-08, Vol.64 (16), p.5850-5860
Hauptverfasser:	WHITMORE, Mark M, DEVEER, Michael J, EDLING, Andrea, OATES, Rhonda K, SIMONS, Brenna, LINDNER, Daniel, WILLIAMS, Bryan R. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Line CpG Islands - immunology Dendritic Cells - immunology Dendritic Cells - metabolism DNA - immunology DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology Enzyme Activation Humans Interferon Type I - immunology Interleukin-12 - biosynthesis Interleukin-12 - genetics Interleukin-12 - immunology Interleukin-6 - biosynthesis Interleukin-6 - genetics Interleukin-6 - immunology Interleukin-8 - biosynthesis Interleukin-8 - genetics Interleukin-8 - immunology Lung - metabolism Macrophage Activation - immunology Macrophages - immunology Macrophages - metabolism Macrophages - physiology Medical sciences Melanoma, Experimental - immunology Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Mice Mice, Inbred C57BL Mice, Knockout Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Pharmacology. Drug treatments Poly I-C - pharmacology Promoter Regions, Genetic Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology RNA, Double-Stranded - immunology Toll-Like Receptor 9 Toll-Like Receptors Transfection Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Tumors
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