Immune recognition of self in immunity against cancer

Most antigens expressed by human cancer cells and recognized by host T cells and antibodies are nonmutated self antigens - molecules also expressed on the surface of normal cells. These self antigens are ineffective at triggering immune responses against cancer cells, which provides one explanation...

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Veröffentlicht in:	The Journal of clinical investigation 2004-08, Vol.114 (4), p.468-471
Hauptverfasser:	Houghton, Alan N, Guevara-Patiño, José A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neoplasm - immunology Antigens, Neoplasm - immunology Autoantigens - immunology Bacteria - pathogenicity Biomedical research Humans Major Histocompatibility Complex - immunology Models, Immunological Neoplasms - immunology Peptides - genetics Peptides - immunology Self Tolerance T-Lymphocytes - immunology
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